Results 91 to 100 of about 1,553 (134)
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Journal of Medicinal Chemistry, 1979
A series of hexofuranosyladenine nucleosides have been tested as substrates and inhibitors of adenosine deaminase from calf intestinal mucosa. The nucleosides differed from each other in configuration at the various carbon atoms of the hexose and had either a methyl group or hydroxymethyl group at the terminal position.
A J, Grant, L M, Lerner
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A series of hexofuranosyladenine nucleosides have been tested as substrates and inhibitors of adenosine deaminase from calf intestinal mucosa. The nucleosides differed from each other in configuration at the various carbon atoms of the hexose and had either a methyl group or hydroxymethyl group at the terminal position.
A J, Grant, L M, Lerner
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Role of cytidine deaminase in toxicity and efficacy of nucleosidic analogs
Expert Opinion on Drug Metabolism & Toxicology, 2014Nucleosidic analogs such as pyrimidine and purine derivatives are mainstay in the field of treating cancers, both in adults and in children. All these drugs act as antimetabolite compounds, that is, they interfere with the ability of cancer cells to synthesize the nucleosides or the nucleotides necessary for proliferation and progression.
Cindy, Serdjebi +2 more
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Clinical Immunology and Immunopathology, 1979
Abstract Red cell adenosine deaminase (ADA) and nucleoside phosphorylase (NP) activities were measured in 62 patients with various immunodeficiency syndromes and in 67 adult and 37 infant controls. NP activity was found to be within the normal range (1206 ± 144 U/gHb in adults, 1266 ± 270 U/gHb in infants) in all but 4 patients who had NP deficiency ...
S H, Chen +3 more
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Abstract Red cell adenosine deaminase (ADA) and nucleoside phosphorylase (NP) activities were measured in 62 patients with various immunodeficiency syndromes and in 67 adult and 37 infant controls. NP activity was found to be within the normal range (1206 ± 144 U/gHb in adults, 1266 ± 270 U/gHb in infants) in all but 4 patients who had NP deficiency ...
S H, Chen +3 more
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Deaminases of purines, pyrimidines, nucleosides and nucleotides
1967The enzymes comprising this group catalyse the hydrolytic cleavage of the amino group in aminopurines and aminopyrimidines. Most of these enzymes possess a high degree of specificity, not only with regard to the particular purine or pyrimidine base, but also depending on whether the substrate is present in the form of the free base, or in combined form
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Adenosine Deaminase and Purine Nucleoside Phosphorylase Activities during Culturing of Fibrolasts
1980Fibroblast cultures can be used as a valuable model for the study of inborn errors and as an important diagnostic tool, e.g. amniotic fluid derived fibroblasts in prenatal diagnosis (1–3). In order to develop reliable enzyme assays of fibroblasts the effect of cell culture conditions on enzyme activities should be known.
M P, Uitendaal +4 more
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[71] Cytosine nucleoside deaminase from Escherichia coli
1955Publisher Summary This chapter discusses the determination of cytosine nucleoside deaminase from Escherichia coli (E. coli) . Spectrophotometric methods are used in following the activity of this enzyme, since the deamination of the cytosine compounds is accompanied b y a decrease in absorption of 55 % at 282 mμ.
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Leukemia Research, 1982
Three enzymes concerned in purine degradation, 5'nucleotidase (5'NT), adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) have been measured biochemically in the bone marrow or peripheral blood blasts from 75 patients with acute leukaemia, from 18 patients with blast crisis of chronic granulocytic leukaemia and in the bone marrow and ...
SYLWESTROWICZ TA +6 more
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Three enzymes concerned in purine degradation, 5'nucleotidase (5'NT), adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) have been measured biochemically in the bone marrow or peripheral blood blasts from 75 patients with acute leukaemia, from 18 patients with blast crisis of chronic granulocytic leukaemia and in the bone marrow and ...
SYLWESTROWICZ TA +6 more
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Synthesis, 2005
Adenosine deaminase (ADA) and adenylic acid deaminase (AMPDA) are enzymes that catalyze the hydrolytic deamination of various purine nucleosides. In light of recent reports, ADA and AMPDA may be considered as valuable biocatalysts in nucleoside chemistry.
E. Santaniello +2 more
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Adenosine deaminase (ADA) and adenylic acid deaminase (AMPDA) are enzymes that catalyze the hydrolytic deamination of various purine nucleosides. In light of recent reports, ADA and AMPDA may be considered as valuable biocatalysts in nucleoside chemistry.
E. Santaniello +2 more
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Biochemical Medicine, 1978
Abstract Previous studies on the urine composition of an adenosine deaminase deficient child have been extended. New analytical procedures have been developed for determination of adenine, deoxyadenosine and adenosine in urine. Of these compounds, deoxyadenosine was the major urinary component.
G C, Mills +3 more
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Abstract Previous studies on the urine composition of an adenosine deaminase deficient child have been extended. New analytical procedures have been developed for determination of adenine, deoxyadenosine and adenosine in urine. Of these compounds, deoxyadenosine was the major urinary component.
G C, Mills +3 more
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Nucleoside Deaminases for Cytidine and Adenosine: Comparison with Deaminases Acting on RNA
2014This chapter reviews the structure of Escherichia coli cytidine deaminase and implications for evolutionary relationships between members of the cytidine deaminase superfamily. It then summarizes details of the E. coli cytidine deaminase (ECCDA) reaction mechanism, with particular reference to the role of conserved residues and aspects of substrate ...
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