Results 11 to 20 of about 2,623 (158)

Combined familial adenosine deaminase and purine nucleoside phosphorylase deficiencies. [PDF]

Archives of Disease in Childhood, 1988
We studied an Arab family in which two infants died of severe combined immunodeficiency caused by adenosine deaminase (ADA) deficiency. One infant had purine nucleoside phosphorylase (PNP) activity in the leucocytes only half that of normal. Four other infant siblings had previously died from infections before the age of 2 months.
A, Shanon, S, Levin, F, Holtzman, F, Brock-Sinai, A, Abu-Said   +4 more
openaire   +2 more sources

Energy metabolism during the maturation of reticulocyte in vitro [PDF]

, 1968
1. For the purpose to clarify the mechanism of the revolutional changes in energy metabolism during the reticulocyte maturation the metabolisms of glucose and of the pentose moieties of acid soluble nucleotides have been observed on rabbit reticulocytes ...
Hayashi, Kenji, Miyahara, Masanobu, Mukai, Jiro, Nakatsuka, Takashi, Seno, Satimaru, Yoshii, Katsuko   +5 more
core   +1 more source

New insights into the biological role of mammalian ADARs; the RNA editing proteins [PDF]

, 2015
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Arieti, Fabiana, Gallo, Angela, Keegan, Liam P., Mannion, Niamh, O'Connell, Mary A.   +4 more
core   +2 more sources

Adenosine deaminase production by an endophytic bacterium (Lysinibacillus sp.) from Avicennia marina [PDF]

, 2013
The present study was carried out with the following objectives: (1) to isolate the endophytic bacilli strains from the leaves of mangrove plant Avicennia marina, (2) to screen the potential strains for the production of adenosine deaminase, (3) to ...
Kandasamy Kathiresan, Kandasamy Saravanakumar, Muthu Sivasankaran, Sunil Kumar Sahu   +3 more
core   +1 more source

Nucleoside deaminase: an enzymatic marker for stress erythropoiesis in the mouse [PDF]

Journal of Clinical Investigation, 1970
The level of nucleoside deaminase was determined in extracts of mouse tissues obtained during a period of accelerated erythropoiesis induced by hypoxia, hemorrhage, or the injection of phenylhydrazine. Under these conditions a striking (10- to 100-fold) elevation of the enzyme activity occurred in the spleen.
Rothman, I K, Zanjani, E D, Gordon, A S, Silber, R   +3 more
openaire   +2 more sources

The role of dinucleoside polyphosphates on the ocular surface and other eye structures [PDF]

, 2016
Dinucleoside polyphosphates comprises a group of dinucleotides formed by two nucleosides linked by a variable number of phosphates, abbreviated NpnN (where n represents the number of phosphates). These compounds are naturally occurring substances present
Carracedo Rodríguez, Juan Gonzalo, Crooke, Almudena, Guzmán Aranguez, Ana María, Pintor, Jesús   +3 more
core   +1 more source

Dextran-Linked Purine Nucleosides as Substrates and Inhibitors of Adenosine Deaminase [PDF]

European Journal of Biochemistry, 1982
Dextran-bound adenosine, inosine, and nebularine have been prepared by carbodiimide coupling of their 2',3'-O-(4-carboxyethyl-1-methylbutylidene) cyclic acetal derivatives to 6-aminohexyldextran or 12-aminododecanyldextran. The latter polymers were prepared by cyanogen-bromide activation of dextran T80 followed by reaction with 1,6-diaminohexane or 1 ...
H, Rosemeyer, E, Körnig, F, Seela
openaire   +2 more sources

Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma brucei [PDF]

, 2016
Thymidine kinase (TK) is a key enzyme in the pyrimidine salvage pathway which catalyzes the transfer of the γ-phosphate of ATP to 2′-deoxythymidine (dThd) forming thymidine monophosphate (dTMP).
Ahmad, Al-Madhoun, Al-Nabulsi, Ali, Amie, Battye, Berrow, Birringer, Birringer, Bolte, Bradshaw, Caligo, Canman, Castillo-Acosta, Castillo-Acosta, Chang, Chen, Chen, Clayton, Creek, Cummings, den Hoff, Dobrovolsky, Emsley, Eriksson, Evans, Glover, Guerra-Giraldez, Hemsworth, Hidalgo-Zarco, Hofer, Hunger-Glaser, Johansson, Ke, Khodursky, Kosinska, Kosinska, Krissinel, Krissinel, Landeira, Lee, Li, Lukas, McCoy, McNicholas, Murshudov, Mutahir, Navalgund, O'Donovan, Ong, Ranjbarian, Reichard, Requena, Schindelin, Segura-Pena, Segura-Pena, Sherley, Sienkiewicz, Simarro, Thiel, Timm, Triest, Tu, Vodnala, Wakazono, Welin, Winn, Wirtz, Wirtz, Yang   +69 more
core   +1 more source

Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury [PDF]

, 2005
Acute respiratory distress syndrome (ARDS) usually requires symptomatic supportive therapy by intubation and mechanical ventilation with the supplemental use of high oxygen concentrations.
, Agorreta, Ahmad, Akio Ohta, Alexander Chouker, Andonegui, Apasov, Bell, Bosco, Brown, Carvalho, Charles Caldwell, Chen, Chris Haslett, Decking, Derevianko, Dharmana, Dmitry Lukashev, Edward Jackson, Eltzschig, Estenssoro, Freeman, Gardinali, Goss, Guida, Hasko, Headley, Iris Bittmann, Ishida, Khoa, Kotani, Lachmann, Lahat, LeClaire, Leeper-Woodford, Linden, Lukashev, Madjdpour, Malbouisson, Manfred Thiel, Martin, Matuschak, Michail V Sitkovsky, Nader-Djalal, Ndengele, Ohta, Patrick Smith, Pietersma, Pinhu, Pizov, Regel, Simms, Sitkovsky, Sue, Sullivan, Tateda, Thiel, Thiel, Tremblay, Tsan, Uchiba, Ward, Wieland   +62 more
core   +5 more sources

Nucleoside analog studies indicate mechanistic differences between RNA-editing adenosine deaminases [PDF]

Nucleic Acids Research, 2012
Adenosine deaminases acting on RNA (ADAR1 and ADAR2) are human RNA-editing adenosine deaminases responsible for the conversion of adenosine to inosine at specific locations in cellular RNAs. Since inosine is recognized during translation as guanosine, this often results in the expression of protein sequences different from those encoded in the genome ...
Mizrahi, Rena A., Phelps, Kelly J., Ching, Andrea Y., Beal, Peter A.   +3 more
openaire   +2 more sources