Distinct Phage-Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes. [PDF]
Adv Sci (Weinh)Distinct enzymes including dCTP deaminases (Dcds), dTMP phosphatases (Dtms), and dTTP pyrophosphatases (Dtt) are found to be responsible for dU‐DNA biosynthesis in the phages PBS1, DSS3_VP1, and PhiR1‐37. Both PhiR1‐37‐derived and synthetic dU‐DNA are resistant to cleavage by restriction enzymes and Cas12a nuclease targeting dT‐containing sites.
Li Y +7 more
europepmc +2 more sources
Combined familial adenosine deaminase and purine nucleoside phosphorylase deficiencies. [PDF]
Archives of Disease in Childhood, 1988 We studied an Arab family in which two infants died of severe combined immunodeficiency caused by adenosine deaminase (ADA) deficiency. One infant had purine nucleoside phosphorylase (PNP) activity in the leucocytes only half that of normal. Four other infant siblings had previously died from infections before the age of 2 months.
A, Shanon +4 more
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Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]
, 2016 Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
core +1 more source
PLoS ONE, 2019 Oral administration of nucleotide analogues and injection of interferon-α (IFNα) are used to achieve immediate suppression in replication of hepatitis B virus (HBV).
Yutaka Furutani +12 more
doaj +1 more source
Energy metabolism during the maturation of reticulocyte in vitro [PDF]
, 1968 1. For the purpose to clarify the mechanism of the revolutional changes in energy metabolism during the reticulocyte maturation the metabolisms of glucose and of the pentose moieties of acid soluble nucleotides have been observed on rabbit reticulocytes ...
Hayashi, Kenji +5 more
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New insights into the biological role of mammalian ADARs; the RNA editing proteins [PDF]
, 2015 The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Arieti, Fabiana +4 more
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Adenosine deaminase production by an endophytic bacterium (Lysinibacillus sp.) from Avicennia marina [PDF]
, 2013 The present study was carried out with the following objectives: (1) to isolate the endophytic bacilli strains from the leaves of mangrove plant Avicennia marina, (2) to screen the potential strains for the production of adenosine deaminase, (3) to ...
Kandasamy Kathiresan +3 more
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Direct Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease. [PDF]
Adv Sci (Weinh)This study introduces two orthogonal sequencing methods, CMD1‐Deaminase sequencing (CD‐seq) and CMD1‐TET bisulfite sequencing (CT‐seq), that enable direct, independent detection of 5mC. Using these approaches together with ACE‐seq or TAB‐seq for 5hmC identification, the study reveals a significant reduction in 5hmC, but not 5mC, in the hippocampus of ...
Wang ZX +15 more
europepmc +2 more sources
Nucleoside deaminase: an enzymatic marker for stress erythropoiesis in the mouse [PDF]
Journal of Clinical Investigation, 1970 The level of nucleoside deaminase was determined in extracts of mouse tissues obtained during a period of accelerated erythropoiesis induced by hypoxia, hemorrhage, or the injection of phenylhydrazine. Under these conditions a striking (10- to 100-fold) elevation of the enzyme activity occurred in the spleen.
Rothman, I K +3 more
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Dextran-Linked Purine Nucleosides as Substrates and Inhibitors of Adenosine Deaminase [PDF]
European Journal of Biochemistry, 1982 Dextran-bound adenosine, inosine, and nebularine have been prepared by carbodiimide coupling of their 2',3'-O-(4-carboxyethyl-1-methylbutylidene) cyclic acetal derivatives to 6-aminohexyldextran or 12-aminododecanyldextran. The latter polymers were prepared by cyanogen-bromide activation of dextran T80 followed by reaction with 1,6-diaminohexane or 1 ...
H, Rosemeyer, E, Körnig, F, Seela
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