Results 21 to 30 of about 2,632 (160)

Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma brucei [PDF]

, 2016
Thymidine kinase (TK) is a key enzyme in the pyrimidine salvage pathway which catalyzes the transfer of the γ-phosphate of ATP to 2′-deoxythymidine (dThd) forming thymidine monophosphate (dTMP).
Ahmad, Al-Madhoun, Al-Nabulsi, Ali, Amie, Battye, Berrow, Birringer, Birringer, Bolte, Bradshaw, Caligo, Canman, Castillo-Acosta, Castillo-Acosta, Chang, Chen, Chen, Clayton, Creek, Cummings, den Hoff, Dobrovolsky, Emsley, Eriksson, Evans, Glover, Guerra-Giraldez, Hemsworth, Hidalgo-Zarco, Hofer, Hunger-Glaser, Johansson, Ke, Khodursky, Kosinska, Kosinska, Krissinel, Krissinel, Landeira, Lee, Li, Lukas, McCoy, McNicholas, Murshudov, Mutahir, Navalgund, O'Donovan, Ong, Ranjbarian, Reichard, Requena, Schindelin, Segura-Pena, Segura-Pena, Sherley, Sienkiewicz, Simarro, Thiel, Timm, Triest, Tu, Vodnala, Wakazono, Welin, Winn, Wirtz, Wirtz, Yang   +69 more
core   +1 more source

Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury [PDF]

, 2005
Acute respiratory distress syndrome (ARDS) usually requires symptomatic supportive therapy by intubation and mechanical ventilation with the supplemental use of high oxygen concentrations.
, Agorreta, Ahmad, Akio Ohta, Alexander Chouker, Andonegui, Apasov, Bell, Bosco, Brown, Carvalho, Charles Caldwell, Chen, Chris Haslett, Decking, Derevianko, Dharmana, Dmitry Lukashev, Edward Jackson, Eltzschig, Estenssoro, Freeman, Gardinali, Goss, Guida, Hasko, Headley, Iris Bittmann, Ishida, Khoa, Kotani, Lachmann, Lahat, LeClaire, Leeper-Woodford, Linden, Lukashev, Madjdpour, Malbouisson, Manfred Thiel, Martin, Matuschak, Michail V Sitkovsky, Nader-Djalal, Ndengele, Ohta, Patrick Smith, Pietersma, Pinhu, Pizov, Regel, Simms, Sitkovsky, Sue, Sullivan, Tateda, Thiel, Thiel, Tremblay, Tsan, Uchiba, Ward, Wieland   +62 more
core   +5 more sources

Nucleoside analog studies indicate mechanistic differences between RNA-editing adenosine deaminases [PDF]

Nucleic Acids Research, 2012
Adenosine deaminases acting on RNA (ADAR1 and ADAR2) are human RNA-editing adenosine deaminases responsible for the conversion of adenosine to inosine at specific locations in cellular RNAs. Since inosine is recognized during translation as guanosine, this often results in the expression of protein sequences different from those encoded in the genome ...
Mizrahi, Rena A., Phelps, Kelly J., Ching, Andrea Y., Beal, Peter A.   +3 more
openaire   +2 more sources

The role of dinucleoside polyphosphates on the ocular surface and other eye structures [PDF]

, 2016
Dinucleoside polyphosphates comprises a group of dinucleotides formed by two nucleosides linked by a variable number of phosphates, abbreviated NpnN (where n represents the number of phosphates). These compounds are naturally occurring substances present
Carracedo Rodríguez, Juan Gonzalo, Crooke, Almudena, Guzmán Aranguez, Ana María, Pintor, Jesús   +3 more
core   +1 more source

136 HIV-1 Nef regulates activity of endoplasmic reticulum chaperone calnexin [PDF]

, 2014
HIV-1 Nef promotes viral replication by downmodulating a number of cell surface transmembrane proteins, such as CD4, MHC-I and MHC-II, which are targeted by Nef to various degradation pathways.
Bukrinsky*, Michael, Dubrovsky, Larisa, Fitzgerald, Michael L., Hunegnaw, Ruth, Jennelle, Lucas, Pushkarsky, Tatiana, Sviridov, Dmitri   +6 more
core   +1 more source

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s) [PDF]

Proceedings of the National Academy of Sciences, 1977
Inherited deficiencies of the enzymes adenosine deaminase (adenosine aminohydrolase; EC 3.5.4.4) and purine nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase; EC 2.4.2.1) preferentially interfere with lymphocyte development while sparing most other organ systems.
D A, Carson, J, Kaye, J E, Seegmiller
openaire   +2 more sources

Importance of adenosine-to-inosine editing adjacent to the anticodon in an Arabidopsis alanine tRNA under environmental stress

, 2013
In all organisms, transfer RNAs (tRNAs) undergo extensive post-transcriptional modifications. Although base modifications in the anticodon are known to alter decoding specificity or improve decoding accuracy, much less is known about the functional ...
Bock, R., Karcher, D., Zhou, W.
core   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters

The Journal of Clinical Pharmacology, EarlyView.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Nancy Agrawal, Janet Hammond   +9 more
wiley   +1 more source

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review

Medicine Bulletin, EarlyView.
ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng, Rui Li, Huan Li, Jun Zhou, Xuanshi Liu, Guilherme Valente, Tatiana de Campos Melo, Sifan Chen, Lei Gu   +8 more
wiley   +1 more source