Results 1 to 10 of about 197,362 (384)

Marine Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis

Marine Drugs, 2014
Nucleosides are glycosylamines that structurally form part of nucleotide molecules, the building block of DNA and RNA. Both nucleosides and nucleotides are vital components of all living cells and involved in several key biological processes.
Ri-Ming Huang, Yin-Ning Chen, Ziyu Zeng, Cheng-Hai Gao, Xiangdong Su, Yan Peng   +5 more
doaj   +2 more sources

Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese.

PLoS ONE, 2013
Urinary nucleosides are associated with many types of cancer. In this study, six targeted urinary nucleosides, namely adenosine, cytidine, 3-methylcytidine, 1-methyladenosine, inosine, and 2-deoxyguanosine, were chosen to evaluate their role as ...
Wei-Yi Hsu, Chao-Jung Chen, Yu-Chuen Huang, Fuu-Jen Tsai, Long-Bin Jeng, Chien-Chen Lai   +5 more
doaj   +2 more sources

Bacteria-specific modified nucleoside is released and elevated in urine of patients with bacterial infections [PDF]

mBio
Over 170 types of chemical modifications have been identified in cellular RNAs across the three domains of life. Modified RNA is eventually degraded to constituent nucleosides, and in mammals, modified nucleosides are released into the extracellular ...
Ryosuke Yamamura, Yu Nagayoshi, Kayo Nishiguchi, Hitomi Kaneko, Keiichi Yamamoto, Koki Matsushita, Miho Shimamura, Akihiro Kunisawa, Korin Sakakida, Takeshi Chujo, Masataka Adachi, Yutaka Kakizoe, Yuichiro Izumi, Takashige Kuwabara, Masashi Mukoyama, Kazuhito Tomizawa   +15 more
doaj   +2 more sources

Palladium-Catalyzed Modification of Unprotected Nucleosides, Nucleotides, and Oligonucleotides

Molecules, 2015
Synthetic modification of nucleoside structures provides access to molecules of interest as pharmaceuticals, biochemical probes, and models to study diseases.
Kevin H. Shaughnessy
doaj   +2 more sources

One-Flow, Multi-Step Synthesis of Nucleosides via Brønsted Acid- Catalyzed Glycosylation [PDF]

Angewandte Chemie, 2010
Nucleosides in flow: A general, scalable method of Brønsted acid-catalyzed nucleoside formation is described. Because of the high reaction temperatures readily available to the flow reaction format, mild Brønsted acids, particularly pyridinium triflates,
Bedore, Matthew W., Jamison, Timothy F., Sniady, Adam   +2 more
core   +2 more sources

Synthesis and Antimicrobial, Anticancer and Anti-Oxidant Activities of Novel 2,3-Dihydropyrido[2,3-d]pyrimidine-4-one and Pyrrolo[2,1-b][1,3]benzothiazole Derivatives via Microwave-Assisted Synthesis

Molecules, 2022
In our attempt towards the synthesis and development of effective antimicrobial, anticancer and antioxidant agents, a novel series of 2,3-dihydropyrido[2,3-d]pyrimidin-4-one 7a–e and pyrrolo[2,1-b][1,3]benzothiazoles 9a–e were synthesized.
Aamal A. Al-Mutairi, Hend N. Hafez, Abdel-Rhaman B. A. El-Gazzar, Marwa Y. A. Mohamed   +3 more
doaj   +1 more source

COMPLEX-FORMING PROPERTIES OF SYNTHETIC PYRIMIDINONE NUCLEOSIDES WITH Ag(I) IONS IN AN AQUEOUS SOLUTION [PDF]

Acta Poloniae Pharmaceutica, 2023
The present work describes the complexation properties of two synthetic nucleosides (used as ligands), i.e. β-D-ribofuranoside-4-pyrimidinone (ribo) and β-D-deoxyribofuranoside-4-pyrimidinone (deoxy) with Ag(I) ions in aqueous solution.
Marek Pająk, Magdalena Woźniczka, Mirosława Świątek, Bartłomiej Czerwiński, Jakub Włodarczyk, Jakub Fichna   +5 more
doaj   +1 more source

SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES [PDF]

Biotechnologia Acta, 2013
Some recent findings in the biotechnology of biologically important nucleosides will be discussed, viz., (i) a new strategy of the cascade one-pot transformation of D-pentoses into nucleosides based on the extension and deepening of the knowledge of the ...
A. Mikhailopulo, A. I. Miroshnikov
doaj   +1 more source

Glycosyl ortho-(1-phenylvinyl)benzoates versatile glycosyl donors for highly efficient synthesis of both O-glycosides and nucleosides

Nature Communications, 2020
Both of O-glycosides and nucleosides are important biomolecules with crucial rules in numerous biological processes. Chemical synthesis is an efficient and scalable method to produce well-defined and pure carbohydrate-containing molecules for deciphering
Penghua Li, Haiqing He, Yunqin Zhang, Rui Yang, Lili Xu, Zixi Chen, Yingying Huang, Limei Bao, Guozhi Xiao   +8 more
semanticscholar   +1 more source

Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation

Metabolites, 2021
Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potential ...
Kuei-Hung Lai, Bo-Rong Peng, Chun-Han Su, Mohamed El-Shazly, Yi-Long Sun, Ming-Cheng Shih, Yu-Ting Huang, Pei-Tzu Yen, Lung-Shuo Wang, Jui-Hsin Su   +9 more
doaj   +1 more source