Results 1 to 10 of about 193,772 (411)
Chemical Society Reviews, 2018 The incorporation of biomolecules into nanomaterials generates functional nanosystems with novel and advanced properties, presenting great potential for applications in various fields.
Fang Pu, Jinsong Ren, Xiaogang Qu
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Marine Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis
Marine Drugs, 2014 Nucleosides are glycosylamines that structurally form part of nucleotide molecules, the building block of DNA and RNA. Both nucleosides and nucleotides are vital components of all living cells and involved in several key biological processes.
Ri-Ming Huang +5 more
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Chemical Reviews, 2016 Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy have been treated with one or more of these analogs. This review focuses on the
Raymond F Schinazi
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Bacteria-specific modified nucleoside is released and elevated in urine of patients with bacterial infections [PDF]
mBioOver 170 types of chemical modifications have been identified in cellular RNAs across the three domains of life. Modified RNA is eventually degraded to constituent nucleosides, and in mammals, modified nucleosides are released into the extracellular ...
Ryosuke Yamamura +15 more
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Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese.
PLoS ONE, 2013 Urinary nucleosides are associated with many types of cancer. In this study, six targeted urinary nucleosides, namely adenosine, cytidine, 3-methylcytidine, 1-methyladenosine, inosine, and 2-deoxyguanosine, were chosen to evaluate their role as ...
Wei-Yi Hsu +5 more
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Strained Conformations of Nucleosides in Active Sites of Nucleoside Phosphorylases [PDF]
Biomolecules, 2020 Nucleoside phosphorylases catalyze the reversible phosphorolysis of nucleosides to heterocyclic bases, giving α-d-ribose-1-phosphate or α-d-2-deoxyribose-1-phosphate. These enzymes are involved in salvage pathways of nucleoside biosynthesis. The level of
Irina A. Il’icheva +2 more
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Recent advances in synthetic approaches for medicinal chemistry of C-nucleosides
Beilstein Journal of Organic Chemistry, 2018 C-nucleosides have intrigued biologists and medicinal chemists since their discovery in 1950's. In that regard, C-nucleosides and their synthetic analogues have resulted in promising leads in drug design. Concurrently, advances in chemical syntheses have
Katherine L Seley-radtke
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Interaction of Nucleosides and Related Compounds with Nucleic Acids as Indicated by the Change of Helix-Coil Transition Temperature [PDF]
, 1962 A series of compounds has been tested for effectiveness in lowering the melting temperature of poly A and of thymus DNA. The order of increasing activity was found to be: adonitol, methyl riboside (both negligible) < cyclohexanol < phenol, pyrimidine ...
Helmkamp, G. K. +2 more
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Palladium-Catalyzed Modification of Unprotected Nucleosides, Nucleotides, and Oligonucleotides
Molecules, 2015 Synthetic modification of nucleoside structures provides access to molecules of interest as pharmaceuticals, biochemical probes, and models to study diseases.
Kevin H. Shaughnessy
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Nucleoside Triphosphate-Nucleoside Diphosphate Transphosphorylase (Nucleoside Diphosphokinase)
Journal of Biological Chemistry, 1964 Abstract Previous physical studies from this laboratory by sedimentation velocity and diffusion and by sedimentation equilibrium (Yue, R. H., Ratliff, R. L., and Kuby, S. A. (1967) Biochemistry 6, 2923–2932) have permitted an assignment of the kinetic molecular weight of the crystalline brewers' yeast nucleoside diphosphokinase, namely 102,000 (±2,000)
Robert L. Ratliff +3 more
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