Results 1 to 10 of about 151,614 (341)

Strained Conformations of Nucleosides in Active Sites of Nucleoside Phosphorylases [PDF]

Biomolecules, 2020
Nucleoside phosphorylases catalyze the reversible phosphorolysis of nucleosides to heterocyclic bases, giving α-d-ribose-1-phosphate or α-d-2-deoxyribose-1-phosphate. These enzymes are involved in salvage pathways of nucleoside biosynthesis. The level of
Irina A. Il’icheva, Konstantin M. Polyakov, Sergey N. Mikhailov   +2 more
doaj   +3 more sources

Bacteria-specific modified nucleoside is released and elevated in urine of patients with bacterial infections [PDF]

mBio
Over 170 types of chemical modifications have been identified in cellular RNAs across the three domains of life. Modified RNA is eventually degraded to constituent nucleosides, and in mammals, modified nucleosides are released into the extracellular ...
Ryosuke Yamamura, Yu Nagayoshi, Kayo Nishiguchi, Hitomi Kaneko, Keiichi Yamamoto, Koki Matsushita, Miho Shimamura, Akihiro Kunisawa, Korin Sakakida, Takeshi Chujo, Masataka Adachi, Yutaka Kakizoe, Yuichiro Izumi, Takashige Kuwabara, Masashi Mukoyama, Kazuhito Tomizawa   +15 more
doaj   +2 more sources

Synthesis and Antimicrobial, Anticancer and Anti-Oxidant Activities of Novel 2,3-Dihydropyrido[2,3-d]pyrimidine-4-one and Pyrrolo[2,1-b][1,3]benzothiazole Derivatives via Microwave-Assisted Synthesis

Molecules, 2022
In our attempt towards the synthesis and development of effective antimicrobial, anticancer and antioxidant agents, a novel series of 2,3-dihydropyrido[2,3-d]pyrimidin-4-one 7a–e and pyrrolo[2,1-b][1,3]benzothiazoles 9a–e were synthesized.
Aamal A. Al-Mutairi, Hend N. Hafez, Abdel-Rhaman B. A. El-Gazzar, Marwa Y. A. Mohamed   +3 more
doaj   +1 more source

COMPLEX-FORMING PROPERTIES OF SYNTHETIC PYRIMIDINONE NUCLEOSIDES WITH Ag(I) IONS IN AN AQUEOUS SOLUTION [PDF]

Acta Poloniae Pharmaceutica, 2023
The present work describes the complexation properties of two synthetic nucleosides (used as ligands), i.e. β-D-ribofuranoside-4-pyrimidinone (ribo) and β-D-deoxyribofuranoside-4-pyrimidinone (deoxy) with Ag(I) ions in aqueous solution.
Marek Pająk, Magdalena Woźniczka, Mirosława Świątek, Bartłomiej Czerwiński, Jakub Włodarczyk, Jakub Fichna   +5 more
doaj   +1 more source

SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES [PDF]

Biotechnologia Acta, 2013
Some recent findings in the biotechnology of biologically important nucleosides will be discussed, viz., (i) a new strategy of the cascade one-pot transformation of D-pentoses into nucleosides based on the extension and deepening of the knowledge of the ...
A. Mikhailopulo, A. I. Miroshnikov
doaj   +1 more source

Ortho-(1-phenylvinyl)benzyl glycosides: Ether-type glycosyl donors for the efficient synthesis of both O-glycosides and nucleosides

Green Synthesis and Catalysis, 2020
Both O-glycosides and nucleosides are essential biomolecules with important roles in a variety of biological processes. Chemical synthesis of both O-glycosides and nucleosides is a scalable and reliable method to develop new therapeutic agents and ...
Penghua Li, Haiqing He, Lili Xu, Yingying Huang, Zixi Chen, Yunqin Zhang, Rui Yang, Guozhi Xiao   +7 more
doaj   +1 more source

Testicular disposition of clofarabine in rats is dependent on equilibrative nucleoside transporters

Pharmacology Research & Perspectives, 2021
Acute lymphoblastic leukemia (ALL) is the most common cancer in children and adolescents. Although the 5‐year survival rate is high, some patients respond poorly to chemotherapy or have recurrence in locations such as the testis. The blood–testis barrier
Siennah R. Miller, Joseph L. Jilek, Meghan E. McGrath, Raymond K. Hau, Erin Q. Jennings, James J. Galligan, Stephen H. Wright, Nathan J. Cherrington   +7 more
doaj   +1 more source

Anti-Proliferative Potential of Secondary Metabolites from the Marine Sponge Theonella sp.: Moving from Correlation toward Causation

Metabolites, 2021
Marine sponges have been recognized as a rich source of potential anti-proliferative metabolites. Currently, there are two sponge-derived anti-cancer agents (a macrolide and a nucleoside) isolated from the Porifera phylum, suggesting the great potential ...
Kuei-Hung Lai, Bo-Rong Peng, Chun-Han Su, Mohamed El-Shazly, Yi-Long Sun, Ming-Cheng Shih, Yu-Ting Huang, Pei-Tzu Yen, Lung-Shuo Wang, Jui-Hsin Su   +9 more
doaj   +1 more source

An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)

Molecules, 2013
An efficient and facile strategy has been developed for bromination of nucleosides using sodium monobromoisocyanurate (SMBI). Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine ...
Roger Stromberg, Jyotirmoy Maity
doaj   +1 more source

Targeted metabolomics analysis of nucleosides and the identification of biomarkers for colorectal adenomas and colorectal cancer

Frontiers in Molecular Biosciences, 2023
The morbidity and mortality of colorectal cancer (CRC) have been increasing in recent years, and early detection of CRC can improve the survival rate of patients. RNA methylation plays crucial roles in many biological processes and has been implicated in
Weifang Zheng, Mingwei Wang, Xiaoyin Chai, Fuzhen Pan, Meihui Xu, Yingchen Wang, Liuhao Lan, Feiran Hu, Zhe Zhang, Zhu Chen   +9 more
doaj   +1 more source