An Aminoisoxazole‐Based Proto‐RNA
ChemistryEurope, 2023 The RNA world hypothesis predicts that life started with the development of replicating and catalytically active RNA, which evolved in a process of molecular evolution to increasingly complex chemical structures.
Felix Xu +4 more
doaj +1 more source
Transport in hybrid electronic devices based on a modified DNA nucleoside (deoxyguanosine) [PDF]
arXiv, 2000 We report on a new class of hybrid electronic devices based on a DNA nucleoside (deoxyguanosine lipophilic derivative) whose assembled polymeric ribbons interconnect a submicron metallic gate. The device exhibits large conductivity at room temperature, rectifying behaviour and strong current-voltage hysteresis.
arxiv
A user-friendly Matlab program and GUI for the pseudorotation analysis of saturated five-membered ring systems based on scalar coupling constants [PDF]
, 2008 Background: The advent of combinatorial chemistry has revived the interest in five-membered heterocyclic rings as scaffolds in pharmaceutical research. They are also the target of modifications in nucleic acid chemistry.
Hendrickx, Pieter, Martins, José
core +4 more sources
Distribution of Nucleosides in Populations of Cordyceps cicadae
Molecules, 2014 A rapid HPLC method had been developed and used for the simultaneous determination of 10 nucleosides (uracil, uridine, 2'-deoxyuridine, inosine, guanosine, thymidine, adenine, adenosine, 2'-deoxyadenosine and cordycepin) in 10 populations of Cordyceps ...
Wenbo Zeng +7 more
semanticscholar +1 more source
Advanced Synthesis &Catalysis, Volume 367, Issue 5, March 4, 2025.Abstract Photochemical C−C coupling reactions can be tailored to industrial chemical processes and preparations of pharmaceuticals. Recent approaches in this area are limited to using precious transition metal coordination complexes that facilitate light absorption and redox processes with benchtop chemicals. Herein, we propose a paradigm that involves
Samjhana Maharjan +9 more
wiley +1 more source
Time-Resolved Emission Study of a Thiophene-Modified Fluorescent Nucleoside in Solution and within Multiply-Modified Oligodeoxynucleotides [PDF]
arXiv, 2014 Steady-state and time-resolved emission techniques were employed to study the photophysical properties of 5-(thien-2-yl)-2'-deoxyuridine (dUTh), an isomorphic fluorescent nucleoside analog. We found that the emission lifetime of dUTh is dependent upon the solvent viscosity and obeys the F\"orster-Hoffman relation over a wide range of temperatures in 1 ...
arxiv
Covalent binding studies on the 14C-labeled antitumour compound 2,5-bis(1-aziridinyl)-1,4-benzoquinone. Involvement of semiquinone radical in binding to DNA, and binding to proteins and bacterial macromolecules in situ [PDF]
, 1990 2,5-Bis(1-aziridinyl)-1,4-benzoquinone (BABQ) is a compound from which several antitumour drugs are derived, such as Trenimone, Carboquone and Diaziquone (AZQ).
Egberink, Richard J.M. +5 more
core +2 more sources
Advanced Science, EarlyView.This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang +8 more
wiley +1 more source
Stepping and crowding of molecular motors: statistical kinetics from an exclusion process perspective [PDF]
, 2013 Motor enzymes are remarkable molecular machines that use the energy derived from the hydrolysis of a nucleoside triphosphate to generate mechanical movement, achieved through different steps that constitute their kinetic cycle. These macromolecules, nowadays investigated with advanced experimental techniques to unveil their molecular mechanisms and the
arxiv +1 more source
Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]
, 2017 Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M. +7 more
core +2 more sources