Results 101 to 110 of about 197,362 (384)

Mitochondria‐Targeting Abasic Site‐Reactive Probe (mTAP) Enables the Manipulation of Mitochondrial DNA Levels

Angewandte Chemie, EarlyView.
Mitochondria‐targeting water‐soluble probe mTAP exclusively reacts with mitochondrial abasic sites, enabling the manipulation of mitochondrial DNA levels under genotoxic stress. Abstract Mitochondrial DNA (mtDNA) encodes essential genes for mitochondrial and cellular functions and acts as a cell signaling molecule in innate immune and inflammatory ...
Anal Jana, Yu‐Hsuan Chen, Linlin Zhao
wiley   +2 more sources

N-Ribosyltransferase From Archaeoglobus veneficus: A Novel Halotolerant and Thermostable Biocatalyst for the Synthesis of Purine Ribonucleoside Analogs

Frontiers in Bioengineering and Biotechnology, 2020
Nucleoside-2′-deoxyribosyl-transferases (NDTs) catalyze a transglycosylation reaction consisting of the exchange of the 2′-deoxyribose moiety between a purine and/or pyrimidine nucleoside and a purine and/or pyrimidine base.
Javier Acosta, Jon Del Arco, Victor Pisabarro, Federico Gago, Jesús Fernández-Lucas, Jesús Fernández-Lucas   +5 more
doaj   +1 more source

Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease

Advanced Science, EarlyView.
This study introduces two orthogonal sequencing methods, CMD1‐Deaminase sequencing (CD‐seq) and CMD1‐TET bisulfite sequencing (CT‐seq), that enable direct, independent detection of 5mC. Using these approaches together with ACE‐seq or TAB‐seq for 5hmC identification, the study reveals a significant reduction in 5hmC, but not 5mC, in the hippocampus of ...
Zi‐Xin Wang, Faying Chen, Bao‐Dan He, Fan‐Chen Wang, Jiaxue Cha, Yu Song, Wei‐Ying Meng, Wan‐Yue Zou, Yu‐Tao Fu, Shu‐Xia Sun, Zhi‐Yan Sun, Hao‐Ming Jiang, Ke‐Yao Zhao, Yujun Hou, Jiejun Shi, Jian‐Huang Xue   +15 more
wiley   +1 more source

Applications of nucleoside-based molecular probes for the in vivo assessment of tumour biochemistry using positron emission tomography (PET)

Brazilian Archives of Biology and Technology, 2007
Positron emission tomography (PET) is a non-invasive nuclear imaging technique. In PET, radiolabelled molecules decay by positron emission. The gamma rays resulting from positron annihilation are detected in coincidence and mapped to produce three ...
Leonard I. Wiebe
doaj   +1 more source

Targeting HDAC and PARP Enhances STING‐Dependent Antitumor Immunity in STING‐Deficient Tumor

Advanced Science, EarlyView.
Dual HDAC and PARP inhibition restores STING signaling, enhances interferon response, and boosts antitumor immunity in STING‐deficient tumors. . Abstract The stimulator of interferon genes (STING)‐mediated innate immune pathway plays an important role in tumor immunosurveillance.
Chengzhou Mao, Weiwen Fan, Jiaqi Liu, Fangzhou Yang, Wenkai Li, Lulu Li, Zhichao Shi, Qinyuan Li, Zigao Yuan, Yuyang Jiang, Bizhu Chu   +10 more
wiley   +1 more source

Rapid Synthesis and Diversification of Thymine‐Containing Bridged Nucleic Acids Through Cascade Cyclization Reactions

Angewandte Chemie, EarlyView.
Several processes are reported that enable the rapid diversification of bridged nucleoside analogues (NAs) starting from a common and readily prepared fluorohydrin. Also, several clinically relevant bridged nucleosides are now prepared in as few as three synthetic steps, creating new opportunities for examining structure‐activity relationships within ...
Cohan Huxley, Ethan Fung, Bara Singh, Guillermo Caballero‐García, Garrett Muir, Steven M. Silverman, Louis‐Charles Campeau, Robert Britton   +7 more
wiley   +2 more sources

Production and Structure Study of Free Radicals of Bases and Nucleosides in Gas Phase [PDF]

Zhipu Xuebao
Nucleoside free radicals have important functions in organisms and play a crucial role in DNA damage. Accurately understanding the structure of nucleoside free radicals is crucial for studying their properties, reaction mechanisms, and interactions with ...
KOU Min1, XU Shi-yin1, JIAO Lu-yang1, DU Meng-ying1, LI Shu-qi1, KONG Xiang-lei1,2,3   +5 more
doaj   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, EarlyView.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source

Converging Fate of the Oxidation and Reduction of 8-Thioguanosine

Molecules, 2019
Thione-containing nucleobases have attracted the attention of the scientific community for their application in oncology, virology, and transplantology.
Katarzyna Taras-Goslinska, Fabrizio Vetica, Sebastián Barata-Vallejo, Virginia Triantakostanti, Bronisław Marciniak, Chryssostomos Chatgilialoglu   +5 more
doaj   +1 more source

Emerging cGAS‐STING Agonist‐Based Nanotherapeutics: Mechanistic Insights and Applications in Cancer Combination Therapy

Advanced Science, EarlyView.
This review summarizes recent advances in cGAS‐STING agonist‐based nanotherapeutics for cancer combination therapy. It explores nanoparticle‐mediated delivery strategies, underlying molecular mechanisms, and combinatorial applications with chemotherapy, radiotherapy, targeted therapy, phototherapy, sonodynamic therapy, and immunotherapy.
Zhaomeng Wang, Yongjun Wang, Zhonggui He, Caigang Liu   +3 more
wiley   +1 more source