Reactivity of Carbohydrate Phosphodiesters, Potential Targets of Antibacterial Agents
Chemistry &Biodiversity, EarlyView.A simple carbohydrate phosphodiester model was synthesized to compare the reactivity of phosphodiester bonds within carbohydrates and RNA. ABSTRACT While monosaccharide units in bacterial carbohydrates may be linked with phosphodiester bonds, human carbohydrates exclusively contain glycosidic linkages.
Eero Sillanpää +2 more
wiley +1 more source
Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application
Chemistry &Biodiversity, EarlyView.ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade +4 more
wiley +1 more source
DEGRADATION OF SUBSTITUTED PYRIMIDINE NUCLEOSIDES BY ESCHERICHIA COLI AND BACILLUS SUBTILIS
, 1954 Irving J. Slotnick +2 more
openalex +1 more source
Evidence of the Presence of 1-Phosphohistidine as the Main Phosphorylated Component at the Active Site of Bovine Liver Nucleoside Diphosphate Kinase. [PDF]
, 1969 Olov Wålinder +7 more
openalex +1 more source
Functional Analysis of Histidine‐Dependent Self‐Cleaving RNAs Obtained by In Vitro Selection
ChemBioChem, EarlyView.Ribozymes can be nucleic acid medicines given their catalytic activity. We attempted to obtain functional RNAs that mimic ribonuclease A catalytic mechanisms. Functional RNAs with high histidine specificity were obtained, suggesting that histidine acts in active structure formation.
Nae Sakimoto +8 more
wiley +1 more source
Simultaneous Quantification of Nucleosides and Nucleotides from Biological Samples
Journal of the American Society for Mass Spectrometry, 2019 Liqing He +8 more
semanticscholar +1 more source
Advances and Challenges in Bioprocess Optimization for the Synthesis of Sugar Nucleotides
ChemBioChem, EarlyView.The emergence of flow biocatalysis for the production of glycan building blocks, sugar nucleotides, is considered. Sugar nucleotides represent the cornerstone building blocks for glycan biosynthesis. While methods to access these crucial biomolecules using traditional batch synthetic chemistry and enzymatic approaches have blossomed, uptake using flow ...
Tom L. Roberts +2 more
wiley +1 more source
ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism
ChemBioChem, EarlyView.ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler +2 more
wiley +1 more source