Results 131 to 140 of about 36,245 (244)

A new role for PHYHD1 and related dioxygenases: demethylation of 2'-O-methylated nucleosides. [PDF]

Nucleic Acids Res
Stonkus J, Rutkienė R, Meškienė R, Jasiūnienė M, Aučynaitė A, Kalinienė L, Lazutka J, Balčiūnas D, Vilkaitis G, Meškys R.   +9 more
europepmc   +1 more source

Photodegradable Hydrogels for On‐Demand Modeling of Age‐Related Spatiotemporal ECM Deformation

Small, EarlyView.
A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Felix Reul, Cédric Bergerbit, Iulia Scarlat, Teodora Piskova, Vasudha Turuvekere Krishnamurthy, Aleksandra N. Kozyrina, Stacy Lok Sze Yam, Laura De Laporte, Jacopo Di Russo   +8 more
wiley   +1 more source

Light‐Guided Molecular Patterning for High‐Throughput Single‐Molecule Mechanical Characterization

Small, EarlyView.
A light‐guided molecular patterning method is presented for high‐throughput single‐molecule characterization. The approach enables scalable and accessible molecular patterning without specialized lithography equipment. Patterned surfaces are compatible with downstream biophysical assays, demonstrated by magnetic tweezers and flow‐based single‐molecule ...
Hansol Choi, Andrew Ward, Wesley P. Wong
wiley   +1 more source

Pentose bisphosphate pathway can act in central metabolism for nucleoside-dependent growth of <i>Thermococcus kodakarensis</i> strains. [PDF]

Appl Environ Microbiol
Nishida T, Chen Y, Azuma T, Orita I, Fukui T.   +4 more
europepmc   +1 more source

Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4‐Mediated Ferroptosis

Small, EarlyView.
ABSTRACT Pancreatic cancer, one of the most malignant solid tumors with the poorest prognosis, is commonly treated with gemcitabine (GEM)‐based systemic chemotherapy. However, chemoresistance remains a significant therapeutic challenge. Ferroptosis, a novel form of programmed cell death, has demonstrated exceptional susceptibility in chemoresistant ...
Jiaqiang Ren, Shuai Wu, Tong Su, Hugang Li, Jiachun Ding, Fan Chen, Jiantao Mo, Jie Li, Zheng Wang, Liang Han, Zheng Wu   +10 more
wiley   +1 more source

Rapid access to the core of malayamycin A by intramolecular dipolar cycloaddition. [PDF]

Beilstein J Org Chem
Liu Y, Yang Y, Yang C, Huang SH, Jin J, Hong R.   +5 more
europepmc   +1 more source

Congenital CMV Infection: Determination of Transplacental Passage of Aciclovir by Ex Vivo Placental Perfusion

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To quantify the transplacental transfer of aciclovir at an amount equivalent to 2 g of valaciclovir corresponding to the fractionated dosing regimen given four times daily used to reduce congenital cytomegalovirus (CMV) transmission and to treat the CMV‐infected fetus. Design Experimental ex vivo study.
Helyett Ollivier, Valentine Faure Bardon, Leo Froelicher Bournaud, Isidore Gaubert, Tiffany Guilleminot, Marianne Leruez‐Ville, Jean‐Marc Treluyer, Yves Ville, Gabrielle Lui, Julien Stirnemann   +9 more
wiley   +1 more source

Integrative analyses of the transcriptome and metabolome of Huzhang (Pinellia pedatisecta Schott) uncover the molecular genetic basis of its medicinal properties. [PDF]

BMC Genomics
Pan C, Chen J, Qian Z.
europepmc   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Dependence of <i>Mycoplasma bovis</i> on a novel nucleoside transporter for survival in association with host cells. [PDF]

Appl Environ Microbiol
Geng S, Premachandre CK, Sharma S, De Souza DP, Elahee Doomun SN, Hondrogiannis J, Kanci Condello A, Browning GF, Klose SM, Tivendale KA, Wawegama NK.   +10 more
europepmc   +1 more source