Results 151 to 160 of about 151,614 (341)

Efficacy of DNA Intercalator‐Conjugated Triplex‐Forming Oligonucleotide as Anticancer Agent

ChemMedChem, EarlyView.
The binding affinity of triplex‐forming oligonucleotide (TFO) is successfully improved for human epidermal growth factor receptor type2 (HER2) gene sequence by using DNA intercalator. The higher binding affinity of TFO for HER2 gene sequence are correlated with the anticancer activity induced by the TFO and resulted in stronger cell death response of ...
Haruki Toyama, Akira Toriba, Atsushi Shibata, Takehiko Wada, Asako Yamayoshi, Yu Mikame   +5 more
wiley   +1 more source

Direct and efficient synthesis of nucleosides through the ortho-(tert-butylethynyl)phenyl thioglycosides (BEPTs) protocol. [PDF]

Nat Commun
Liu H, Wang MY, Xie H, Qiu Y, Mao T, Shen X, Liu XX, Guo JJ, Tang MZ, Liao JX, Tu YH, Liu DY, Sun JS.   +12 more
europepmc   +1 more source

Electrochemical Characterization of Site‐Specifically Metal‐Modified DNA Films on Gold Electrode Surfaces

ChemPlusChem, EarlyView.
DNA films containing different CuII‐ or AgI‐mediated base pairs are investigated with respect to their electrochemical properties and how these depend on the size and charge of the artificial metal‐binding nucleobase as well as the location of the metal‐mediated base pair within the duplex.
Nils Flothkötter, Nils Lefringhausen, Daniela Escher, Jens Müller, Heinz‐Bernhard Kraatz   +4 more
wiley   +1 more source

Optimization of <i>q</i> Value for Sensitive Detection of Uridine and Thymidine Nucleosides by MS³. [PDF]

J Am Soc Mass Spectrom
Duan Z, Wang C, Wang Y.
europepmc   +1 more source

Nucleoside Antibiotics

, 1968
Bruce M. Chassy, Robert J. Suhadolnik
openalex   +1 more source

Biologically Active Nucleosides [PDF]

Current Protocols in Nucleic Acid Chemistry, 2005
openaire   +11 more sources

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source

Modified nucleosides as biomarkers for early cancer diagnose in exposed populations

Environmental Toxicology, 2015
Annerose Seidel, Peter Seidel, O. Manuwald, O. Herbarth   +3 more
semanticscholar   +1 more source

Coapplication of Adenine with Inosine or Guanosine Supports Rapid ATP Restoration by ATP-deprived Cultured Primary Astrocytes. [PDF]

Neurochem Res
Karger G, Dringen R.
europepmc   +1 more source

Sustainable Natural Product Glycosylation: A Critical Evaluation of Biocatalytic and Chemical Approaches

ChemSusChem, EarlyView.
Developing a process to produce glycosylated natural products involves many decisions, and given the current climate crisis, the environmental impact of the various processes must be a major consideration. This review provides an overview of the various processes and a framework for which metrics should be quantified to select processes that are both ...
Felipe Mejia‐Otalvaro, Brianna Marie Lax, Onur Kırtel, Ditte Hededam Welner   +3 more
wiley   +1 more source