Results 171 to 180 of about 197,362 (384)

C1′‐Branched Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium Falciparum 6‐Oxopurine Phosphoribosyltransferase

ChemMedChem, EarlyView.
Novel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Jan Frydrych, Dianne T. Keough, Haojun Xia, Lenka Poštová Slavětínská, Martin Dračínský, Michal Česnek, Jye Travis, Marina Chavchich, Michael Edstein, Dana Hocková, Luke W. Guddat, Zlatko Janeba   +11 more
wiley   +1 more source

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source

Experimental conditions affecting ribonucleic acid polymerase in isolated rat liver nuclei. Effect of nucleoside triphosphate concentration, temperature, ammonium sulphate and heparin [PDF]

, 1969
F. Novello, Fiorenzo Stirpe
openalex   +1 more source

Dideoxyapiose nucleosides revisited : syntheses and protide derivatives [PDF]

, 2011
Balzarini, Jan, Toti, Kiran, Van Calenbergh, Serge   +2 more
core   +1 more source

Extracellular nucleosides and nucleotides as immunomodulators

Immunological Reviews, 2017
O. Kepp, Friedemann Loos, Peng Liu, G. Kroemer   +3 more
semanticscholar   +1 more source

Identification of Candidate Blood Biomarkers of Recombinant Human Erythropoietin Administration Using Targeted Polar Metabolomics by HILIC‐MS/MS

Drug Testing and Analysis, EarlyView.
Using targeted HILIC‐MS/MS metabolomics, inosine and hypoxanthine were identified as potential biomarkers of EPO administration. Their consistent and sensitive plasma responses highlight their promise for inclusion in the Athlete Biological Passport (ABP), warranting further investigation to enhance anti‐doping detection strategies. ABSTRACT Increasing
Olivier Salamin, Lejla Ramic, Raul Nicoli, Serge Rudaz, Davy Guillarme, Tiia Kuuranne   +5 more
wiley   +1 more source

THE DISSOCIATION CONSTANTS OF PLANT NUCLEOTIDES AND NUCLEOSIDES AND THEIR RELATION TO NUCLEIC ACID STRUCTURE

, 1925
P.A. Levene, Henry S. Simms
openalex   +1 more source

5‐Bromo‐8‐Nitro‐1‐Naphthoic Acid as Protective Group for Alcohols Under Mitsunobu Conditions

European Journal of Organic Chemistry, EarlyView.
Protection of alcohols is carried out using the readily available 5‐bromo‐8‐nitro‐1‐naphthoic acid (NNapOH). Under Mitsunobu conditions, primary and secondary alcohols are converted into the corresponding esters, which are subsequently deprotected under mild reduction conditions. The use of the readily available 5‐bromo‐8‐nitro‐1‐naphthoic acid (NNapOH)
Estela Sánchez‐Santos, Irene Boya del Teso, José J. Garrido‐González, Joaquín R. Morán, Ángel L. Fuentes de Arriba, Victoria Alcázar   +5 more
wiley   +1 more source

Effect of Nucleosides on Acute Left Ventricular Failure in the Isolated Dog Heart

, 1959
N. M. Buckley, K.K. Tsuboi, Norman J. Zeig   +2 more
openalex   +1 more source

Contactless Conductivity Detection for Capillary Electrophoresis—Developments From 2020 to 2024

ELECTROPHORESIS, EarlyView.
ABSTRACT The review covering the development of capillary electrophoresis with capacitively coupled contactless conductivity detection from 2020 to 2024 is the latest in a series going back to 2004. The article considers applications employing conventional capillaries and planar lab‐on‐chip devices as well as fundamental and technical developments of ...
Peter C. Hauser, Pavel Kubáň
wiley   +1 more source