Results 11 to 20 of about 151,614 (341)
Marine Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis
Marine Drugs, 2014 Nucleosides are glycosylamines that structurally form part of nucleotide molecules, the building block of DNA and RNA. Both nucleosides and nucleotides are vital components of all living cells and involved in several key biological processes.
Ri-Ming Huang +5 more
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Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese.
PLoS ONE, 2013 Urinary nucleosides are associated with many types of cancer. In this study, six targeted urinary nucleosides, namely adenosine, cytidine, 3-methylcytidine, 1-methyladenosine, inosine, and 2-deoxyguanosine, were chosen to evaluate their role as ...
Wei-Yi Hsu +5 more
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Palladium-Catalyzed Modification of Unprotected Nucleosides, Nucleotides, and Oligonucleotides
Molecules, 2015 Synthetic modification of nucleoside structures provides access to molecules of interest as pharmaceuticals, biochemical probes, and models to study diseases.
Kevin H. Shaughnessy
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Diversification of 4′-Methylated Nucleosides by Nucleoside Phosphorylases [PDF]
ACS Catalysis, 2021 The growing demand for 4'-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules and the lack of efficient diversification strategies. Herein, we report the development of a biocatalytic diversification approach based on nucleoside phosphorylases, which allows the ...
Felix Kaspar +11 more
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Sensors, 2006 A rigid molecular clip comprising bisphosphonate binding sites and aromaticsidewalls forming an electron-rich cavity is able to distinguish between nucleosides andnucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereofare drawn into the unpolar interior of the cleft and lead to substantial upfield-shifts in the 1HNMR
Fokkens, Michael +2 more
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Nature Communications, 2020 Both of O-glycosides and nucleosides are important biomolecules with crucial rules in numerous biological processes. Chemical synthesis is an efficient and scalable method to produce well-defined and pure carbohydrate-containing molecules for deciphering
Penghua Li +8 more
semanticscholar +1 more source
Synthesis of Modified Nucleosides [PDF]
Current Protocols in Nucleic Acid Chemistry, 2003 Peer Reviewed ; https://deepblue.lib.umich.edu/bitstream/2027.42/143685/1/cpnc0100 ...
Roger Jones, Piet Herdewijn
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Nature Communications, 2018 The molecules of life were created by a continuous physicochemical process on an early Earth. In this hadean environment, chemical transformations were driven by fluctuations of the naturally given physical parameters established for example by wet–dry ...
S. Becker +6 more
semanticscholar +1 more source
Synthesis of Natural Product-Like Tricyclic Higher-Carbon Sugar Nucleosides
Pharmaceutical Fronts, 2021 Because of the structural novelty and interesting biological profiles, the synthesis of higher-carbon sugars has been highly pursued. In this work, we first synthesized a series of structurally novel bis-uracil containing tricyclic higher-carbon sugar ...
Xiao-Han Yuan +4 more
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