Results 191 to 200 of about 151,614 (341)

Clinical Evaluation of Drug–Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P‐gp Pathways

The Journal of Clinical Pharmacology, EarlyView.
Abstract In addition to antiretroviral therapy (ART), people with HIV often take medications to treat comorbidities. It is therefore important to assess these medications for potential drug‐drug interactions, which may affect the safety and efficacy of ART. Three phase I studies were conducted in adult participants without HIV. The pharmacokinetics (PK)
Priyanka Arora, Hui Liu, John Ling, Jason T. Hindman, Dhananjay D. Marathe   +4 more
wiley   +1 more source

Quantifying the mRNA epitranscriptome reveals epitranscriptome signatures and roles in cancer. [PDF]

Cell Mol Life Sci
Feng Y, He X, Guo M, Tang Y, Qi G, Huang Q, Ma W, Chen H, Qin Y, Li R, Wang J, Liu Y.   +11 more
europepmc   +1 more source

Pentosyl Transfer Mechanisms of the Mammalian Nucleoside Phosphorylases

, 1968
Thomas A. Krenitsky
openalex   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters

The Journal of Clinical Pharmacology, EarlyView.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Nancy Agrawal, Janet Hammond   +9 more
wiley   +1 more source

Preclinical Evaluation of a Novel Molecule Targeting Nucleoside Homeostasis to Restore Energy Metabolism and Cognitive Function in Alzheimer's Disease. [PDF]

Pharmacol Res Perspect
Wu KC, Lin CY, Tran T, Lin JH, Yeh HH, Ho CJ, Chern Y, Lin CJ.   +7 more
europepmc   +1 more source

Purification and Properties of Nucleoside Hydrolase from Pseudomonas fluorescens

, 1967
Masaaki Terada, Masamiti Tatibana, Osamu Hayaishi   +2 more
openalex   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Landscape of targets within nucleoside metabolism for the modification of immune responses. [PDF]

Front Oncol
Dunderdale EM, Abt ER.
europepmc   +1 more source

On the Benzylation of Nucleosides. II. A Novel Synthesis of 2'-O-Benzyluridine

, 1968
Kiyomi Kikugawa, Fumiko Sato, Takashi Tsuruo, Nobumasa Imura, Tyunosin Ukita   +4 more
openalex   +2 more sources

Availability of Bases and Nucleosides as Precursors of Nucleic Acids in L Cells and in the Agent of Meningopneumonitis [PDF]

, 1966
Ilse I. E. Tribby, James W. Moulder
openalex   +1 more source