Results 191 to 200 of about 193,772 (411)

Gene and RNA Editing: Methods, Enabling Technologies, Applications, and Future Directions [PDF]

arXiv
Gene and RNA editing methods, technologies, and applications are emerging as innovative forms of therapy and medicine, offering more efficient implementation compared to traditional pharmaceutical treatments. Current trends emphasize the urgent need for advanced methods and technologies to detect public health threats, including diseases and viral ...
arxiv  

SOME CHEMICAL PROPERTIES OF DESOXYRIBOSE NUCLEOSIDES

, 1951
Lionel A. Manson, J. O. Lampen
openalex   +1 more source

NUCLEOSIDE TRIPHOSPHATE POOLS AND THE REGULATION OF RNA SYNTHESIS IN E. coli [PDF]

, 1969
Gordon Edlin, Gunther S. Stent
openalex   +1 more source

Synthesis of 2‐Substituted Adenosine Triphosphate Derivatives and their use in Enzymatic Synthesis and Postsynthetic Labelling of RNA

ChemBioChem, EarlyView.
A series of 2‐substituted adenosine 5′‐O‐triphosphate derivatives is synthesized and tested as substrates for polymerases. In vitro transcription with T7 RNA polymerase, primer extension with engineered DNA polymerases, or 3′‐labelling with poly(A) polymerase are used for enzymatic synthesis of base‐modified RNA.
Ugnė Šinkevičiūtė, Tania Sanchez‐Quirante, Samanta Rožánková, Lenka Poštová Slavětínská, Veronika Raindlová, Michal Hocek   +5 more
wiley   +1 more source

Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration

ChemBioChem, Accepted Article.
Modified nucleosides play important roles as agents in medicinal chemistry due to their anti‐inflammatory, antiviral and anti‐proliferative properties, as well as in biochemical processes like protein biosynthesis. Aminoacylated nucleosides in tRNA represent the central transfer unit of amino acids in the biosynthesis of peptides.
Oliver Trapp, Nathalie J. Kurrle, Christoph J. B. Seifert, Nathalie Hampel, Tamara Rauch, Michael Thoma, Luca V. Parziale, Marian S. R. Ebeling, Dino Berthold   +8 more
wiley   +1 more source

Nucleoside diphosphate sugars and saccharide synthesis [PDF]

, 1964
LF Leloir
openalex   +1 more source

Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

Chemistry – A European Journal, EarlyView.
This review highlights recent advances in mechanochemical methods for multistep organic synthesis, focusing on sequential one‐pot approaches performed by grinding or ball milling. The presented transformations are discussed in terms of efficiency, applicability, and sustainability, assessing both the challenges and potential of solvent‐free one‐pot ...
Nina Biedermann, Michael Schnürch
wiley   +1 more source

Extracellular nucleosides and nucleotides as immunomodulators

Immunological Reviews, 2017
O. Kepp, Friedemann Loos, Peng Liu, G. Kroemer   +3 more
semanticscholar   +1 more source

Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high‐grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models

Cancer Communications, EarlyView.
Monika Raab, Balázs Győrffy, Samuel Peña‐Llopis, Daniela Fietz, Monika Kressin, Margareta Kolaric, Matthias Ebert, Khayal Gasimli, Sven Becker, Mourad Sanhaji, Klaus Strebhardt   +10 more
wiley   +1 more source

Polymerase Synthesis of Hypermodified DNA Displaying a Combination of Thiol, Hydroxyl, Carboxylate, and Imidazole Functional Groups in the Major Groove

Chemistry – A European Journal, EarlyView.
A series of 2’‐deoxyribonucleoside 5’‐O‐triphosphates bearing functional groups of amino acid side chains in enzyme active sites (OH, SH, COOH, and imidazole) were synthesized and used for enzymatic synthesis of hypermodified DNA displaying these substituents in the major groove mimicking peptides or proteins. Abstract We designed and synthesized a set
Lukáš Kaiser, Marek Ondruš, Lenka Poštová Slavětínská, Veronika Raindlová, Michal Hocek   +4 more
wiley   +1 more source