Results 191 to 200 of about 71,761 (247)

Studies of Nucleosides and Nucleotides. XLIII, Purine Cyclonucleosides.(10). Optical Rotatory Dispersion and Circular Dichroism of Adenine 8-Cyclonucleosides

, 1971
Morio Ikehara, Masakatsu Kaneko, Yuji Nakahara, Shoji Yamada, Seiichi Uesugi   +4 more
openalex   +2 more sources

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Occurrence, Properties, Applications and Analytics of Cytosine and Its Derivatives. [PDF]

Molecules
Kluska M, Jabłońska J, Prukała D, Prukała W.   +3 more
europepmc   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Enzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors. [PDF]

Nat Commun
Meng Q, Benckendorff C, Morrill C, Zhuo Y, Egerström A, Ní Cheallaigh A, Derrington SR, Obexer R, Ortmayer M, Levy CW, Finnigan JD, Charnock SJ, Turner NJ, Miller GJ, Lovelock SL.   +14 more
europepmc   +1 more source

Predictors of discontinuing injectable cabotegravir/rilpivirine and virologic outcomes after resuming oral antiretroviral therapy

HIV Medicine, EarlyView.
Abstract Objective Evaluate factors associated with discontinuation of long‐acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) and describe virologic outcomes in those that returned to oral antiretroviral therapy (ART). Methods This is a retrospective cohort study at a single‐centre primary care HIV clinic.
Tali Faggiano, Jeffrey Yin, Nimish Patel, Afsana Karim, Kari Abulhosn, Laura Bamford, Lucas Hill   +6 more
wiley   +1 more source

Enhancing the Yield of <i>Pleurotus ostreatus</i> Through the Addition of Nucleotides and Nucleosides. [PDF]

J Fungi (Basel)
Tang C, Gao Y, An Z, Sajid AQ, Ying H, Wang Z, Liu D.   +6 more
europepmc   +1 more source

Biochemical Studies of the Nucleoside Analogue, Formycin

, 1969
David C. Ward, Anthony Cerami, E. Reich, George Acs, Lynne Altwerger   +4 more
openalex   +1 more source

Late diagnosis of paediatric HIV infection in high‐income countries: Lessons from the HIV Perinatal Virtual Clinic

HIV Medicine, EarlyView.
Abstract Introduction Timely diagnosis of HIV in children remains a challenge in all settings including low‐prevalence, high‐income countries (HIC). We aimed to characterize the prevalence of late diagnosis, and prior missed diagnostic opportunities among new presentations of paediatric HIV in HIC referred to an international Perinatal Virtual Clinic ...
Carolina Curto, M. Tritzali, A. Bamford, A. C. Bailey, E. G. H. Lyall, N. E. Mackie, N. Tickner, C. Foster, on behalf of the PVC   +8 more
wiley   +1 more source

Selective Acetalization in Pyridine: A Sustainable 5'-<i>O</i>-(2-Methoxypropyl) Protecting Group in the Synthesis of Nucleic Acid Analogs. [PDF]

Org Lett
Saari V, Eerola A, Ora M, Gimenez Molina A, Horvath A, Sanghvi YS, Virta P.   +6 more
europepmc   +1 more source