Results 41 to 50 of about 36,245 (244)
An Aminoisoxazole‐Based Proto‐RNA
ChemistryEurope, 2023 The RNA world hypothesis predicts that life started with the development of replicating and catalytically active RNA, which evolved in a process of molecular evolution to increasingly complex chemical structures.
Felix Xu +4 more
doaj +1 more source
Advanced Materials Technologies, EarlyView.An all‐in‐one microfluidic platform consists of two‐layered PDMS channels integrated with a hydrogel microwell array. This platform enables flow‐driven tumor cell capture, enhanced spheroid formation within the microwells, and advective drug testing. ABSTRACT Effective cancer drug screening requires platforms that replicate the physiological complexity
Omar M. Rahman +2 more
wiley +1 more source
Molecules, 2016 A green protocol has been applied to synthesize a novel series of 3-cyano-2-(tri-O-acetyl-β-d-arabinopyranosylthio)pyridines in a short reaction time, in higher yields and with simpler operations, when compared with the conventional heating method ...
Ibrahim A. Maghrabi +3 more
doaj +1 more source
Do's and Don'ts When Visiting Circularly Polarized Luminescence
Advanced Optical Materials, EarlyView.This perspective presents our insights into the principles, challenges, and opportunities of circularly polarized luminescence (CPL). Highlighting key concepts such as the dissymmetry factor (glum) and molecular design strategies, we discuss advances in CPL efficiency, emerging NIR emitters, solid‐state applications, and the growing role of theory and ...
Rafael G. Uceda +9 more
wiley +1 more source
Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers
Advanced Science, EarlyView.MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao +7 more
wiley +1 more source
Nucleoside Diphosphate Prodrugs [PDF]
Nucleic Acids Symposium Series, 2008 Nucleoside analogs are widely applied in antiviral and antitumor therapy. A severe limitation of these compounds arises from the need of biotransformation to the eventually active nucleoside triphosphates by stepwise addition of phosphate by kinases. This problem can be circumvented by employing reversibly masked nucleotides (prodrugs).
Meier, Chris +2 more
openaire +3 more sources
Advanced Science, EarlyView.This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang +10 more
wiley +1 more source
Biomolecules1,2,4-Triazole derivatives have a wide range of biological activities. The most well-known drug that contains 1,2,4-triazole as part of its structure is the nucleoside analogue ribavirin, an antiviral drug. Finding new nucleosides based on 1,2,4-triazole
Ilya V. Fateev +22 more
doaj +1 more source
Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing
Advanced Science, EarlyView.CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen +15 more
wiley +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source