Results 71 to 80 of about 197,362 (384)
Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues
Molecules, 2020 The strong inhibition of Human Cytomegalovirus (HCMV) replication by benzimidazole nucleosides, like Triciribine and Maribavir, has prompted us to expand the structure–activity relationships of the benzimidazole series, using as a central core the ...
Georgios Papadakis +6 more
doaj +1 more source
Synthesis of 5-substituted 2'-deoxyuridine-5'-phosphonate analogues and evaluation of their antiviral activity [PDF]
, 2012 A small series of 5-(hetero)aryl-modified nucleoside phosphonates was synthesized via an 8-step procedure including a Wittig reaction and Suzuki-Miyaura coupling.
Balzarini, Jan +4 more
core +1 more source
Methylated nucleosides in tRNA and tRNA methyltransferases
Frontiers in Genetics, 2014 To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic pathways of the majority of tRNA modifications include a methylation step(s).
H. Hori
semanticscholar +1 more source
Light‐Harvesting Nanomaterials Based on Dyes for Energy Transfer and Amplified Biosensing
Advanced Materials, EarlyView.Light harvesting (LH) in plants inspires researchers to develop artificial LH nanomaterials. Here, LH nanomaterials based on organic dyes are reviewed, considering fundamental challenges on aggregation‐caused quenching, excitation energy transfer, and exciton migration length.
Andrey S. Klymchenko +2 more
wiley +1 more source
Biomolecules1,2,4-Triazole derivatives have a wide range of biological activities. The most well-known drug that contains 1,2,4-triazole as part of its structure is the nucleoside analogue ribavirin, an antiviral drug. Finding new nucleosides based on 1,2,4-triazole
Ilya V. Fateev +22 more
doaj +1 more source
Molecules, 2013 Various forms of purine-nucleoside phosphorylase (PNP) were used as catalysts of enzymatic ribosylation of selected fluorescent 8-azapurines. It was found that the recombinant calf PNP catalyzes ribosylation of 2,6-diamino-8-azapurine in a phosphate-free
Goran Mikleušević +3 more
doaj +1 more source
DNA Methylation in Acacia mangium ln vitro and Ex-vitro buds, in relation to their within-shoot position, age and leaf morphology of the shoots [PDF]
, 2009 DNA methylation was analyzed in Acacia mangium Willd. buds collected from in vitro and field growing shoots from the same clone and its juvenile offspring.
Baurens, Franc-Christophe +5 more
core +1 more source
Advances and Strategies in Enhancing mRNA Cancer Vaccines
Advanced Materials, EarlyView.Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang +4 more
wiley +1 more source
Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C-nucleosides
Frontiers in Chemistry, 2018 Formyl glycals are the versatile synthetic intermediates and can serves as precursor for the synthesis of various C and N-nucleosides. Due to the presence of electron donating and electron withdrawing character on formyl sugars which makes the molecule ...
Ahmed Bari +6 more
doaj +1 more source
Role of Nucleoside Transporters in Nucleoside-Derived Drug Sensitivity
Nucleosides, Nucleotides and Nucleic Acids, 2010 Nucleoside-derived drugs are currently used clinically as anticancer drugs. To exert their pharmacological action first they need to enter into the cell across plasma membrane transporters and be metabolized. Thus, efficacy of treatment and acquisition of resistance can rely on a variety of events.
Molina-Arcas, Míriam +1 more
openaire +5 more sources