Results 151 to 160 of about 70,917 (227)

Structural basis for BCL7B-mediated ncBAF-nucleosome engagement. [PDF]

Nucleic Acids Res
Sun F, Zou B, Li H, Xu C, Luo Q, Wang C, Xu P, Pei D, Chen J, Qin D, Zhang Y, He J.   +11 more
europepmc   +1 more source

Nucleosome [PDF]

, 2019
openaire   +1 more source

Silencing of the Metabolic Gene HKDC1 Is Associated With Aging and Neurodegeneration in Mice and Humans

Aging Cell, Volume 25, Issue 3, March 2026.
Model showing decline in HKDC1 gene expression with aging. In a young cell, TFEB gets recruited to its binding sites on the HKDC1 promoter to upregulate HKDC1 expression, which interacts with mitochondria and stabilizes PINK1 to maintain mitochondrial health.
Zeenat Farooq, Vladimir Ilievski, James Boyett, Julianne Jorgensen, Yang Pan, Tanika Kelly, David Bennett, Orly Lazarov, Brian T. Layden   +8 more
wiley   +1 more source

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

The FEBS Journal, Volume 293, Issue 5, Page 1495-1515, March 2026.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strong   +6 more
wiley   +1 more source

A Temperature Increase Induces Atf1/Pcr1‐Dependent Rapid Depletion of Histones in Transcriptionally Activated Gene Bodies in Fission Yeast

Genes to Cells, Volume 31, Issue 2, March 2026.
In the fission yeast Schizosaccharomyces pombe, the transcription factor complex Atf1‐Pcr1 is activated by phosphorylation upon heat stress to initiate a rapid cellular response. This activated complex facilitates the significant eviction of histone H3 from the transcribed regions of specific genes termed HOT‐DOGs. RNAP II, depicted as delivery trucks,
Arata Hoshino, Takuya Kajitani, Masaya Oki, Tetsuji Kakutani, Soichi Inagaki   +4 more
wiley   +1 more source

Comprehensive profiling of chromatin occupancy dynamics through the cell cycle. [PDF]

Nucleic Acids Res
Li Y, MacAlpine DM, Hartemink AJ.
europepmc   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Structural characterisation of chromatin remodelling intermediates supports linker DNA-dependent product inhibition as a mechanism for nucleosome spacing. [PDF]

Elife
Hughes AL, Sundaramoorthy R, Owen-Hughes T.   +2 more
europepmc   +1 more source

Apolipoprotein E Deficiency Impairs Human Microglial Proliferation Accompanied by Elevated Cellular Oxidative Stress

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT The APOE gene, which encodes Apolipoprotein E (ApoE), is the strongest genetic risk locus for Alzheimer's disease (AD). A substantial fraction of AD risk genes converges on pathways controlling lipid metabolism and immune regulation, in which microglia serve as a central integrative hub in the brain.
Dayoung Kim, Takayuki Kondo, Keiko Imamura, Kayoko Tsukita, Ayako Nagahashi, Tomoki Sakasai, Haruhisa Inoue   +6 more
wiley   +1 more source

Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nucleosome Mass Spectrometry. [PDF]

ACS Cent Sci
Lee AS, Fisher NP, Marunde MR, Su P, Khan LF, Ezell RJ, Gillespie ZB, Graham B, Taylor HF, Onuoha UC, Su T, Jooß K, Schachner LF, Fuchs HA, Noll K, Meiners MJ, Cheek MA, Burg JM, Sun ZW, Musselman CA, Keogh MC, Kelleher NL.   +21 more
europepmc   +1 more source