Results 71 to 80 of about 141,257 (371)

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Electrophoresis of Positioned Nucleosomes [PDF]

Biophysical Journal, 2007
to appear in Biophys. J.
Martin Castelnovo, Sebastian Grauwin
openaire   +4 more sources

Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells

Advanced Biology, EarlyView.
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe, Samantha Kaonis, Natalie Calahan, Neda Kabi, Soham Ghosh   +4 more
wiley   +1 more source

Nucleosome-coupled expression differences in closely-related species

BMC Genomics, 2011
Background Genome-wide nucleosome occupancy is negatively related to the average level of transcription factor motif binding based on studies in yeast and several other model organisms.
Gebbia Marinella, Tsui Kyle, Yao Victoria, Guan Yuanfang, Dunham Maitreya J, Nislow Corey, Troyanskaya Olga G   +6 more
doaj   +1 more source

Structural basis for nucleosome remodeling by the INO80 complex

Nature, 2018
In the eukaryotic nucleus, DNA is packaged in the form of nucleosomes, each of which comprises about 147 base pairs of DNA wrapped around a histone protein octamer.
S. Eustermann, Kevin Schall, D. Kostrewa, K. Lakomek, M. Strauss, Manuela Moldt, K. Hopfner   +6 more
semanticscholar   +1 more source

DNA Nanomechanics in the Nucleosome [PDF]

Structure, 2009
The sequence-dependent mechanics of DNA-histone binding are essential for nucleosome positioning and mobility. Here we reanalyze nucleosome crystal structures in terms of the well-characterized base-pair scale DNA elasticity, extracting the forces and torques acting on all bound DNA base pairs.
Ralf Everaers, Nils B. Becker
openaire   +3 more sources

Nucleosome destabilization by polyamines

Archives of Biochemistry and Biophysics, 2022
The roles and molecular interactions of polyamines (PAs) in the nucleus are not fully understood. Here their effect on nucleosome stability, a key regulatory factor in eukaryotic gene control, is reported, as measured in agarose embedded nuclei of H2B-GFP expressor HeLa cells.
Laszlo Imre, Erfaneh Firouzi Niaki, Rosevalentine Bosire, Peter Nanasi, Peter Nagy, Zsolt Bacso, Nubar Hamidova, Yves Pommier, Albert Jordan, Gabor Szabo   +9 more
openaire   +3 more sources

High-throughput sequencing reveals a simple model of nucleosome energetics

, 2010
We use nucleosome maps obtained by high-throughput sequencing to study sequence specificity of intrinsic histone-DNA interactions. In contrast with previous approaches, we employ an analogy between a classical one-dimensional fluid of finite-size ...
A. V. Morozov, Adams, D. Tolkunov, Deckert, Fedor, Felsenfeld, Field, G. Locke, Horz, Ioshikhes, Jenuwein, K. Struhl, Kaplan, Kornberg, Lee, Mavrich, Miller, Richmond, Segal, Sekinger, Tillo, Tolstorukov, Wang, Widom, Wingert, Yuan, Z. Moqtaderi   +26 more
core   +1 more source

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains [PDF]

, 2011
The ATP-dependent chromatin-remodelling enzyme Chd1 is a 168-kDa protein consisting of a double chromodomain, Snf2-related ATPase domain, and a C-terminal DNA-binding domain.
Aasland, Adams, Alen, Awad, Bailey, Baker, Baudin, Bird, Biswas, Biswas, Blank, Blosser, Boyer, Cairns, Chen, Cheng, Clapier, Clapier, Corona, Dang, Daniel P Ryan, Daubresse, David Martin, de Vries, Delmas, Eberharter, Eddy, Emsley, Fazzio, Ferreira, Flanagan, Flaus, Gangaraju, Gaspar-Maia, Grune, Hamiche, Hauk, Holm, Konev, Kouzarides, Lin, Lusser, McDaniel, Morettini, Okuda, Painter, Park, Pinskaya, Racki, Ramasubramanian Sundaramoorthy, Robinson, Sikorski, Simic, Sims, Stockdale, Stokes, Thastrom, Thompson, Tom Owen-Hughes, Tran, Tsukiyama, Vijender Singh, Walfridsson, Waterhouse, Yang, Zentner   +65 more
core   +3 more sources

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source