Results 71 to 80 of about 71,049 (222)
Nucleosomes in gene regulation: theoretical approaches [PDF]
Molecular Biology, 2012, Vol. 46, No. 1, pp. 1--10, 2012 This work reviews current theoretical approaches of biophysics and bioinformatics for the description of nucleosome arrangements in chromatin and transcription factor binding to nucleosomal organized DNA. The role of nucleosomes in gene regulation is discussed from molecular-mechanistic and biological point of view. In addition to classical problems of
arxiv +1 more source
H2A.Z controls the stability and mobility of nucleosomes to regulate expression of the LH genes
Nature Communications, 2016 The structure and dynamics of promoter chromatin have a profound effect on the expression levels of genes. Yet, the contribution of DNA sequence, histone post-translational modifications, histone variant usage and other factors in shaping the ...
Sergei Rudnizky +5 more
semanticscholar +1 more source
Histone Tail Dynamics in Partially Disassembled Nucleosomes During Chromatin Remodeling
Frontiers in Molecular Biosciences, 2019 Nucleosomes are structural units of the chromosome consisting of DNA wrapped around histone proteins, and play important roles in compaction and regulation of the chromatin structure.
Takeru Kameda +5 more
doaj +1 more source
CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere
Science, 2015 Building stable centromeres Each of our chromosomes has a single centromere, seen as a constriction during cell division, which is required for accurate chromosome segregation to daughter cells. Falk et al.
Samantha J. Falk +11 more
semanticscholar +1 more source
Nanoscale dynamics of centromere nucleosomes and the critical roles of CENP-A
bioRxiv, 2017 In the absence of a functioning centromere, chromosome segregation becomes aberrant, leading to an increased rate of aneuploidy. The highly specific recognition of centromeres by kinetochores suggests that specific structural characteristics define this ...
Micah P Stumme-Diers +4 more
semanticscholar +1 more source
Scientific Reports, 2016 The mechanisms underlying increased thrombotic risk in chronic myeloproliferative neoplasms (MPN) are incompletely understood. We assessed whether neutrophil extracellular traps (NETs), which promote thrombosis, contribute to the procoagulant state in ...
C. P. Marin Oyarzun +9 more
semanticscholar +1 more source
The size of the nucleosome [PDF]
, 2011 The structural origin of the size of the 11 nm nucleosomal disc is addressed. On the nanometer length-scale the organization of DNA as chromatin in the chromosomes involves a coiling of DNA around the histone core of the nucleosome. We suggest that the size of the nucleosome core particle is dictated by the fulfillment of two criteria: One is ...
arxiv +1 more source
EXTRACELLULAR DNA AND THE LEVEL OF ITS METHYLATION IN DIFFERENT RHEUMATIC DISEASES
Научно-практическая ревматология, 2012 Objective: to study the qualitative and quantitative composition of serum extracellular DNA (exDNA); apoptotic (nucleosomes) and necrotic fragmentation; complexification of monometinic proteins with exDNA; and the levels of exDNA methylation as compared ...
N O Shubayeva +4 more
doaj +1 more source
Structural basis for retroviral integration into nucleosomes
Nature, 2015 Retroviral integration is catalysed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome. How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently ...
D. Maskell +9 more
semanticscholar +1 more source
Gammaretroviruses tether to mitotic chromatin by directly binding nucleosomal histone proteins
Microbial Cell, 2018 The gammaretroviral gag cleavage product, p12, is essential for replication at both early and late stages of the virus life cycle. During the early stage of infection, the viral core is released into the cytoplasm, the viral RNA genome is reversed ...
Madushi Wanaguru, Kate N. Bishop
doaj +1 more source