Results 71 to 80 of about 72,215 (324)
Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis
Advanced Science, EarlyView.Uncovering distinct plasma cfmtDNA breakage patterns opens new frontiers for early sepsis detection and prognosis. Unique cleavage hotspots in RNR2 and COX2 regions outperform traditional biomarkers, while mechanistic insights suggest bacterial endonuclease involvement.
Haitang Liao +13 more
wiley +1 more source
Circulating nucleosomes as new blood-based biomarkers for detection of colorectal cancer
Clinical Epigenetics, 2017 BackgroundColonoscopy is currently widely accepted as the gold standard for detection of colorectal cancer (CRC) providing detection of up to 95% of pre-cancerous lesions during the procedure.
J. Rahier +12 more
semanticscholar +1 more source
Determinants of nucleosome positioning [PDF]
Nature Structural & Molecular Biology, 2013 Nucleosome positioning is critical for gene expression and most DNA-related processes. Here we review the dominant patterns of nucleosome positioning that have been observed and summarize the current understanding of their underlying determinants. The genome-wide pattern of nucleosome positioning is determined by the combination of DNA sequence, ATP ...
Kevin Struhl, Eran Segal
openaire +3 more sources
ISWI catalyzes nucleosome sliding in condensed nucleosome arrays
Nature Structural & Molecular Biology, 2023 SummaryHow chromatin enzymes work in condensed chromatin and how they maintain diffusional mobility inside remains unexplored. We investigated these challenges using theDrosophilaISWI remodeling ATPase, which slides nucleosomes along DNA. Folding of chromatin fibers did not affect slidingin vitro. Catalytic rates were also comparable in- and outside of
Petra Vizjak +10 more
openaire +3 more sources
Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase
Advanced Science, EarlyView.Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo +17 more
wiley +1 more source
Revista Brasileira de Reumatologia, 2012 OBJETIVOS: Determinar a frequência de anticorpos contra componentes da cromatina no lúpus eritematoso sistêmico juvenil (LESJ) e correlacionar a presença desses autoanticorpos com manifestações clínicas e atividade da doença.
Silene Peres Keusseyan +5 more
doaj +1 more source
Abstract OR-19: Integrative Approach on Nucleosome Complexes Modeling [PDF]
International Journal of Biomedicine, 2019 Background: Nucleosomes are the key structural elements of chromatin in all higher organisms. While X-ray crystallography studies of nucleosomes have consistently yielded similar atomistic structures, many biophysical and biochemical techniques suggest ...
Grigoriy A. Armeev +2 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz +14 more
wiley +1 more source
Epigenetic Regulation of Viral Biological Processes
Viruses, 2017 It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. This review will address epigenetic regulation in members of the polyomaviruses, adenoviruses, human papillomaviruses ...
Lata Balakrishnan, Barry Milavetz
doaj +1 more source
Exploring the Free Energy Landscape of Nucleosomes.
Journal of the American Chemical Society, 2016 The nucleosome is the fundamental unit for packaging the genome. A detailed molecular picture for its conformational dynamics is crucial for understanding transcription and gene regulation.
Bin Zhang +3 more
semanticscholar +1 more source