Results 91 to 100 of about 49,625 (309)
Massively multiplex single-molecule oligonucleosome footprinting
eLife, 2020 Our understanding of the beads-on-a-string arrangement of nucleosomes has been built largely on high-resolution sequence-agnostic imaging methods and sequence-resolved bulk biochemical techniques. To bridge the divide between these approaches, we present
Nour J Abdulhay +10 more
doaj +1 more source
Rate heterogeneity of nucleosomes spanning splicing sites.
, 2013 The substitution (A) and indel (B) rates increase from the exonic end of nucleosomes to intronic sites as nucleosomes protrude into introns, and reach the maximum at the linker regions within introns.
Qing Zhou (52712) +5 more
core +1 more source
Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor
Advanced Science, EarlyView.The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao +11 more
wiley +1 more source
Frontiers in Veterinary ScienceIntroductionImmune-mediated hemolytic anemia (IMHA) is an important immunologic disorder in dogs that is associated with high mortality rates, frequently due to thromboembolism.
Robert Goggs +3 more
doaj +1 more source
Journal of Biomedical Science, 2011 Background Colorectal carcinoma is a common and often fatal disease in which methods of early detection and monitoring are essential. The present study was conducted for measuring serum levels of nucleosomes, carcinoembryonic antigen (CEA) and CA 19-9 in
Mahgoub Samir S +2 more
doaj +1 more source
Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing
Advanced Science, EarlyView.A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo +11 more
wiley +1 more source
Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A
Frontiers in Microbiology, 2019 Human herpesvirus-6A (HHV-6A) and 6B (HHV-6B) are two closely related betaherpesviruses that are associated with various diseases including seizures and encephalitis.
Anthony J. Saviola +12 more
doaj +1 more source
Cell-free system for assembly of transcriptionally repressed chromatin from Drosophila Embryos [PDF]
, 1992 We descrtbe a cell·free system, derlved (rom preblastoderm DrosophÜIJ embryos. ror tbe efficient assembly of eloned DNA into chromatin. Tbe cbromatin assembly system ulilizes cndogcDous eure histones aod assembly racton aod yields loog arrays of ...
Earl Wu +3 more
core
Advanced Science, EarlyView.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source
The enhancer H3.3 nucleosomes display higher splitting index than the non-enhancer H3.3 nucleosomes.
, 2013 (A) Box plot of the splitting index of enhancer or non-enhancer H3.3 nucleosomes within the same turnover ranges. (B) Box plot of the splitting index of H3.3 nucleosomes at the enhancers, promoters, 5-UTRs within the same turnover ranges.
Mo Xu (418704) +7 more
core +1 more source