Results 111 to 120 of about 109,383 (351)

Asymmetric nucleosomes flank promoters in the budding yeast genome

Genome Research, 2015
Nucleosomes in active chromatin are dynamic, but whether they have distinct structural conformations is unknown. To identify nucleosomes with alternative structures genome-wide, we used H4S47C-anchored cleavage mapping, which revealed that 5% of budding ...
S. Ramachandran, G. Zentner, S. Henikoff
semanticscholar   +1 more source

Mediator?Nucleosome Interaction [PDF]

Molecular Cell, 2000
Mediator, a multiprotein complex involved in the regulation of RNA polymerase II transcription, binds to nucleosomes and acetylates histones. Three lines of evidence identify the Nut1 subunit of Mediator as responsible for the histone acetyltransferase (HAT) activity. An "in-gel" HAT assay reveals a single band of the appropriate size.
Y, Lorch, J, Beve, C M, Gustafsson, L C, Myers, R D, Kornberg   +4 more
openaire   +2 more sources

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Massively multiplex single-molecule oligonucleosome footprinting

eLife, 2020
Our understanding of the beads-on-a-string arrangement of nucleosomes has been built largely on high-resolution sequence-agnostic imaging methods and sequence-resolved bulk biochemical techniques. To bridge the divide between these approaches, we present
Nour J Abdulhay, Colin P McNally, Laura J Hsieh, Sivakanthan Kasinathan, Aidan Keith, Laurel S Estes, Mehran Karimzadeh, Jason G Underwood, Hani Goodarzi, Geeta J Narlikar, Vijay Ramani   +10 more
doaj   +1 more source

Circulating nucleosomes as epigenetic biomarkers in pancreatic cancer

Clinical Epigenetics, 2015
To improve the prognosis of patients with pancreatic cancer, new biomarkers are required for earlier, pre-symptomatic diagnosis. Epigenetic mutations take place at the earliest stages of tumorigenesis and therefore offer new approaches for detecting and ...
Monika Bauden, Dorian Pamart, D. Ansari, M. Herzog, M. Eccleston, J. Micallef, B. Andersson, R. Andersson   +7 more
semanticscholar   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Whole genome regulatory effect of MoISW2 and consequences for the evolution of the rice plant pathogenic fungus Magnaporthe oryzae

mBio
Isw2 proteins, ubiquitous across eukaryotes, exhibit a propensity for DNA binding and exert dynamic influences on local chromosome condensation in an ATP-dependent fashion, thereby modulating the accessibility of neighboring genes to transcriptional ...
Mengtian Pei, Yakubu Saddeeq Abubakar, Hina Ali, Lianyu Lin, Xianying Dou, Guodong Lu, Zonghua Wang, Stefan Olsson, Ya Li   +8 more
doaj   +1 more source

Colorectal carcinoma: nucleosomes, carcinoembryonic antigen and ca 19-9 as apoptotic markers; a comparative study

Journal of Biomedical Science, 2011
Background Colorectal carcinoma is a common and often fatal disease in which methods of early detection and monitoring are essential. The present study was conducted for measuring serum levels of nucleosomes, carcinoembryonic antigen (CEA) and CA 19-9 in
Mahgoub Samir S, Al-Shuneigat Jehad M, Huq Fazlul   +2 more
doaj   +1 more source

Statistical mechanics of nucleosome ordering by chromatin structure-induced two-body interactions

, 2011
One-dimensional arrays of nucleosomes (DNA-bound histone octamers separated by stretches of linker DNA) fold into higher-order chromatin structures which ultimately make up eukaryotic chromosomes.
Chereji, Răzvan V., Locke, George, Morozov, Alexandre V., Tolkunov, Denis   +3 more
core   +1 more source

The BAH domain of Rsc2 is a histone H3 binding domain [PDF]

, 2013
Bromo-adjacent homology (BAH) domains are commonly found in chromatin-associated proteins and fall into two classes; Remodels the Structure of Chromatin (RSC)-like or Sir3-like. Although Sir3-like BAH domains bind nucleosomes, the binding partners of RSC-
Adams, Angus-Hill, Anna L. Chambers, Antony W. Oliver, Armache, Badis, Bamford, Bochar, Burrows, Cairns, Cairns, Callebaut, CCP4, Chambers, Chen, Corpet, Davis, DeMase, Desai, Downs, Duncker, Emsley, Ericsson, Faucher, Foster, Gartenberg, Gartenberg, Goodwin, Hickman, Hsu, Huang, Jessica A. Downs, Jones, Kabsch, Kasten, Kent, Kuo, Lacoste, Langst, Laurence H. Pearl, Lee, Leslie, Livingstone, Longtine, McCoy, Mohrmann, Muller, Ng, Noguchi, Norris, Norris, Oliver, Onishi, Park, Peng, Ralhan, Shim, Strahl-Bolsinger, Tanny, Varela, Weissman, Xia   +61 more
core   +1 more source