Results 111 to 120 of about 10,982 (239)

Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome [PDF]

, 2007
Objective: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of
Yiannis Ioannou, Lambrianides, A., Anisur Rahman, Isenberg, D.A., Lesley Mason, Giles, I., Ioannou, Y., Latchman, D.S., Mason, L., Jessica J. Manson, Ian Giles, Manson, J.J., David A. Isenberg, David S. Latchman, Rahman, A., Anastasia Lambrianides   +15 more
core   +1 more source

Keeping It Native: Non‐Denaturing Approaches to Top‐Down Protein Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics and top‐down mass spectrometry approaches provide direct characterization of proteoforms; the specific molecular forms of proteins, including post‐translational modifications, truncations, alternative splicing, and sequence variants.
Michael Xiao, Edvaldo Vasconcelos Soares Maciel, Frederik Lermyte, Owen S. Skinner   +3 more
wiley   +1 more source

Histone Tail Dynamics in Partially Disassembled Nucleosomes During Chromatin Remodeling

Frontiers in Molecular Biosciences, 2019
Nucleosomes are structural units of the chromosome consisting of DNA wrapped around histone proteins, and play important roles in compaction and regulation of the chromatin structure.
Takeru Kameda, Akinori Awazu, Akinori Awazu, Yuichi Togashi, Yuichi Togashi, Yuichi Togashi   +5 more
doaj   +1 more source

Nucleosome positioning in Arabidopsis [PDF]

The aim of this project was to test hypotheses relating to nucleosome positioning in Arabidopsis to provide a basis for better understanding of epigenetic transcriptional regulation in plants.
Usher, Sarah Louise
core  

Traceless Synthesis of Asymmetrically Modified Bivalent Nucleosomes

Nucleosomes carry extensive post-translational modifications (PTMs), which results in complex modification patterns that are involved in epigenetic signaling.
Agashe, Ninad D., Fierz, Beat, Lechner, Carolin C.   +2 more
core   +1 more source

Dynamic Remodeling of Individual Nucleosomes Across a Eukaryotic Genome in Response to Transcriptional Perturbation [PDF]

, 2008
Sushma Shivaswamy is with UT Austin, Akshay Bhinge is with UT Austin, Yongjun Zhao is with British Columbia Cancer Agency, Steven Jones is with British Columbia Cancer Agency, Martin Hirst is with British Columbia Cancer Agency, Vishwanath R Iyer is with
Bhinge, Akshay, Vishwanath R Iyer, Zhao Yongjun, Iyer Vishwanath R, Shivaswamy Sushma, Iyer, Vishwanath R, Shivaswamy, Sushma, Jones Steven, Zhao, Yongjun, Yongjun Zhao, Jones, Steven, Martin Hirst, Bhinge Akshay, Steven Jones, Akshay Bhinge, Hirst, Martin, Sushma Shivaswamy, Hirst Martin   +17 more
core   +1 more source

Integration of scRNA‐Seq and scATAC‐Seq Revealed the Role of lncRNA RP11‐661C8.2 by Promoting EMT in Clear Cell Renal Cell Carcinoma

Molecular Carcinogenesis, EarlyView.
ABSTRACT Long noncoding RNAs (lncRNAs) play an important role in tumor progression. However, most of the previously discovered lncRNAs that promote or inhibit tumor progression were derived from bulk RNA‐seq results. Data from single‐cell RNA sequencing (scRNA‐seq) and single‐cell assay for transposase‐accessible chromatin using sequencing (scATAC‐seq)
Jizhen Cen, Xuefang Liang, Zheng Wen, Shengzhu Huang, Jiaping Li, Haibiao Yan, Kaiqiang Tang, Guifen Zhou, Ning Liang, Qi Zheng, Cheng Su, Zengnan Mo, Zhenyuan Yu   +12 more
wiley   +1 more source

Comparison of Nucleosome, Ferritin and LDH Levels in Blood with Clinical Response before and after Electrochemotherapy Combined with IL-12 Gene Electrotransfer for the Treatment of Mast Cell Tumours in Dogs

Animals
Electrochemotherapy (ECT) in combination with the gene electrotransfer of interleukin 12 (IL-12 GET) has been successfully used in veterinary medicine for the treatment of mast cell tumours (MCT), but the biomarkers that could predict response to this ...
Maša Vilfan, Urša Lampreht Tratar, Nina Milevoj, Alenka Nemec Svete, Maja Čemažar, Gregor Serša, Nataša Tozon   +6 more
doaj   +1 more source

KAT8‐Low Osteosarcoma Suppresses Cisplatin Sensitivity via H4K16ac‐Mediated Cell Apoptosis

Med Research, EarlyView.
The scientific significance of this study is highlighted below: (1) Data mining and clinical discovery: These findings establish a direct clinical link between the KAT8–H4K16ac axis and chemotherapy response in osteosarcoma. (2) Multi‐omics and machine‐learning integration: We integrated proteomics and CUT&Tag multi‐omics to elucidate how chromatin ...
Zhenqun Zhao, Guohui Yu, Shikui Wu, Zhiyang Zhang, Keke Wang, Yingxin Xiong, Chao Sun, Haobo Cui, Yuxing Wang, Ziheng Wang, Huiru Zhang, Huiqin Xue, Shibing Guo   +12 more
wiley   +1 more source

A needed nomenclature for nucleosomes

Molecular Cell
Histone post-translational modifications (PTMs) are crucial to eukaryotic genome regulation, with a range of reported functions and mechanisms of action. Though often studied individually, it has long been recognized that the modifications function by combinatorial synergy or antagonism.
Michael-Christopher Keogh, Genevieve Almouzni, Andrew J. Andrews, Karim-Jean Armache, Cheryl H. Arrowsmith, Sung Hee Baek, Mark T. Bedford, Emily Bernstein, Jacques Côté, Yael David, John M. Denu, Beat Fierz, Benjamin A. Garcia, Karen C. Glass, Or Gozani, Kristian Helin, Steven Henikoff, Ole N. Jensen, Steven Z. Josefowicz, Neil L. Kelleher, Tatiana G. Kutateladze, Herbert H. Lindner, Chao Lu, Karolin Luger, Parag Mallick, Catherine A. Musselman, Tom W. Muir, Ljiljana Paša-Tolić, Robert Schneider, Xiaobing Shi, Yang Shi, Simone Sidoli, Lloyd M. Smith, Jessica K. Tyler, Cynthia Wolberger, Jerry L. Workman, Brian D. Strahl, Nicolas L. Young   +37 more
openaire   +3 more sources