Results 121 to 130 of about 10,982 (239)

The enhancer H3.3 nucleosomes display higher splitting index than the non-enhancer H3.3 nucleosomes.

, 2013
(A) Box plot of the splitting index of enhancer or non-enhancer H3.3 nucleosomes within the same turnover ranges. (B) Box plot of the splitting index of H3.3 nucleosomes at the enhancers, promoters, 5-UTRs within the same turnover ranges.
Mo Xu (418704), Yingfeng Li (418705), Chang Huang (418702), Yanting Ma (418706), Zhuqiang Zhang (418703), Zhen Li (49109), Tao Cai (19539), Bing Zhu (145649)   +7 more
core   +1 more source

Nucleosomes effectively shield DNA from radiation damage in living cells

, 2020
Eukaryotic DNA is organized in nucleosomes, which package DNA and regulate its accessibility to transcription, replication, recombination and repair.
Zocchi, Angelica, Monteleone, Emanuele, Hoelzen, Lena, Bianchi, Marco E, Hölzen, Lena, Bianchi, Marco E., Garcia-Manteiga, Jose Manuel, Brambilla, Francesca, Agresti, Alessandra   +8 more
core   +1 more source

Protein Glutamylation: From Cytoskeleton to Signaling

Med Research, EarlyView.
Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen, Yi Yuan, Qingquan Yu, Xinyue Wang, Hui Wang   +4 more
wiley   +1 more source

Bibliometric Analysis of Research on Pituitary Adenomas: Recent Progress in Pathogenesis and Clinical Management

Medicine Advances, EarlyView.
A bibliometric analysis of 15,418 publications mapped global research on pituitary adenomas and identified 6 major research themes. Keyword trends highlighted the growing prominence of artificial intelligence‐related research. ABSTRACT Background Pituitary adenomas (PAs) comprise most of the tumors that originate from the sellar region.
Zhengyang Shen, Kan Deng, Lin Lu, Jifang Liu, Zhang Ye, Yi Zhang, Yong Yao   +6 more
wiley   +1 more source

The epigenetic landscape of plant defense: Unlocking nature's toolkit for new plant protection

New Plant Protection, EarlyView.
This review examines how epigenetic mechanisms regulate plant immune gene activation, repression, and priming, then links these natural regulatory layers to emerging epigenetic editing, discussing their potential for precise, heritable crop protection and the challenges.
Xuexia Liu, Zhenhui Zhong
wiley   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Genomics and epigenomics of tissue repair: Implications for personalized medicine

Precision Medical Sciences, EarlyView.
Genomic and epigenomic mechanisms govern tissue repair and regeneration through dynamic regulation of inflammation, cell fate, and extracellular matrix remodeling. The integration of multi‐omics, artificial intelligence, and precision regenerative therapies enables biomarker‐driven, personalized approaches to enhance healing and minimize fibrosis ...
Jharna Medhi, Chandrashekar Thalluri, Sarad Pawar Naik Bukke, Piyali Dey, Mallikarjun Vasam, Ananda Kumar Chettupalli, Swetha Kumari Koduru, Gali Avinash Kumar   +7 more
wiley   +1 more source

Salt-induced structural changes in nucleosomes

, 1977
Nucleosomes and oligonucleosomes were prepared by digestion of human pla-cental nuclei with staphlococccal nuclease and fractionated by gel filtration chromatography.
Cg. Sahasrabuddhe, Grady F. Saunders
core  

Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri, Ralf Blossey, Fabrizio Cleri   +2 more
wiley   +1 more source

Astragaloside IV Restores Autophagy and Inhibits Apoptosis for Podocyte Protection in Diabetic Nephropathy by Inhibiting Notch1 Signaling via SIRT6‐Mediated Deacetylation

Phytotherapy Research, EarlyView.
AS‐IV binds to SIRT6 and promotes H3K9 deacetylation at the Notch1 promoter, inhibiting gene transcription (Created with BioGDP.com). ABSTRACT Astragaloside IV (AS‐IV) has demonstrated efficacy in ameliorating proteinuria and attenuating renal tubular damage in preclinical diabetic nephropathy (DN) models.
Qiyu Yue, Chen Yong, Xinran Wang, Yang Shu, Min Yao, Yongfei Yu, Yubai Xue, Rong Deng, Tianlu Chu, Weiwei Tao, Min Zhao, Enchao Zhou   +11 more
wiley   +1 more source