Results 131 to 140 of about 10,982 (239)

Integrative proteomic profiling of extracellular vesicle‐enriched preparations with machine learning identifies disease activity‐associated signatures linked to adverse pregnancy outcomes in systemic lupus erythematosus

VIEW, EarlyView.
Integrating cross‐cohort extracellular vesicle proteomics with machine learning identifies a simplified protein signature (AGT, FETUB, SPP2, and FCN3) for adverse pregnancy outcome risk stratification in systemic lupus erythematosus, enabling precise disease‐activity discrimination beyond routine clinical assessment.
Weiwei Shi, Xipei Huang, Wutao Chen, Wen Di, Lin Huang, You Wang   +5 more
wiley   +1 more source

Tetrameric organization of vertebrate centromeric nucleosomes

, 2010
Mitosis ensures equal genome segregation in the eukaryotic lineage. This process is facilitated by microtubule attachment to each chromosome via its centromere.
Emilios K. Dimitriadis, Stephan Diekmann, Yamini Dalal, Christian Weber, Rajbir K. Gill   +4 more
core   +1 more source

Spatiotemporal Expression of ARRDC5 in Mammalian Spermatogenesis

Andrology, EarlyView.
ABSTRACT Background Spermiogenesis is the final phase of sperm development during which haploid round spermatids transform into specialized spermatozoa and occurs across distinct stages of sperm production in the seminiferous epithelium. Abnormalities in this process lead to malformations and an inability of sperm to fertilize eggs.
LeeLa D. Robinson, Jon M. Oatley
wiley   +1 more source

FACT facilitates both RSC-induced remodeling and mobilization of nucleosomes.

, 2016
(A) DNase I footprinting. End-positioned nucleosomes, reconstituted on 32P 5’-labeled 241 bp 601 DNA fragment, were incubated with 0.2 units of RSC in the absence (lane 3) or in the presence of 1.6 pmol of FACT (lane 4) for 50 min at 30°C; lane 5, same ...
Khalid Ouararhni (3145734), John Lalith Charles Richard (463328), Dimitar Angelov (173799), Imtiaz Nisar Lone (173794), Hervé Menoni (641841), Ali Hamiche (3145728), Elsa Ben Simon (3145737), Christophe Papin (3145731), Tapas Kundu (3145725), Yohan Roulland (3145740), Stefan Dimitrov (463330), Manu Shubhdarshan Shukla (463327)   +11 more
core   +1 more source

Chromosomal and immune dysregulation underlying granular mitosis in glioblastoma

Brain Pathology, EarlyView.
Granular mitosis (GM) morphology is linked to PI3K/PTEN pathway alterations, chromosomal disorganization, and impaired innate immunity. Cells exhibiting GM morphology are associated with localized immune responses within their immediate spatial microenvironment.
Rachel Barboza, Xuan Wang, August Lin, Eric Liu, Pramath Kakodkar, Yayuan Zhao, Quinn Le, Christina A. Castellani, Qi Zhang   +8 more
wiley   +1 more source

Unpacking chromatin accessibility with Fiber-seq: general principles with special considerations for plant systems

Frontiers in Epigenetics and Epigenomics
Chromatin accessibility has long been used as a marker for regions of DNA with regulatory potential. Fiber-seq detects chromatin accessibility on individual DNA fibers, enabling analyses beyond the identification of the accessible chromatin regions (ACRs)
Kerry L. Bubb, Molly Perchlik, Josh T. Cuperus, Christine Queitsch   +3 more
doaj   +1 more source

Dynamic Changes of ctDNA‐Based MRD and Genomic Mutations Predict Prognosis in ESCC Treated With Definitive Radiotherapy

Cancer Science, EarlyView.
In patients with esophageal squamous cell carcinoma receiving definitive radiotherapy combined with systemic therapy, posttreatment TP53 mutation clearance and ctDNA‐MRD negativity predict favorable outcomes, whereas persistent ctDNA signals indicate elevated relapse risk, supporting nucleosome‐ and MRD‐informed surveillance and risk‐stratification ...
Shutang Liu, Qi Wang, Chun Han, Xiaoning Li, Rutian Cheng, Lihong Liu, Hua Dong, Xuejiao Ren, Shuman Zhen, Lan Wang   +9 more
wiley   +1 more source

Diagnostic Performance of cfDNA‐Based Liquid Biopsy for Hepatocellular Carcinoma: A Systematic Review and Meta‐Analysis

Cancer Science, EarlyView.
This meta‐analysis demonstrates high diagnostic accuracy of cfDNA‐based liquid biopsy for HCC, with stage‐ and assay‐dependent performance and substantial inter‐study heterogeneity. ABSTRACT Conventional surveillance tools for hepatocellular carcinoma (HCC) have limited sensitivity.
Jiwei Liu, Yangyu Zhang, Shuo Yang, Yanhua Wu, Jing Jiang   +4 more
wiley   +1 more source

A method for cryo-EM analysis of eukaryotic nucleosomes reconstituted in bacterial cells

iScience
Summary: Conventional methods for preparing nucleosomes are time-consuming and technically demanding. In the present study, we extended the approach of generating nucleosomes in Escherichia coli by the co-expression of all four histones, allowing ...
Cheng-Han Ho, Yuki Kobayashi, Mitsuo Ogasawara, Yoshimasa Takizawa, Hitoshi Kurumizaka   +4 more
doaj   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

Cell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng, Yuxiu Lin, Yongyan Gao, Delan Huang, Yuanyuan Li, Honglei Ruan, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
wiley   +1 more source