Results 151 to 160 of about 42,592 (238)

The Fluid Mosaic Model of chromatin organization: integrating dynamics, conformational heterogeneity and multiscale organization. [PDF]

Commun Biol
Wani AH.
europepmc   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Pioneer-factor activity requires stable chromatin occupancy mediated by both sequence-specific binding and disordered protein domains. [PDF]

Sci Adv
Freund MM, deHaro-Arbona FJ, Baloul S, Torhorst A, Roussos C, Ruffridge AJ, Rashoff AQ, Hazzard R, Lewis PW, Bray SJ, Harrison MM.   +10 more
europepmc   +1 more source

Designed Alleles of ZmRap2.7 Decouple the Trade‐Off Between Early Flowering and Yield Penalty

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4966-4983, August 2026.
ABSTRACT Flowering time genes often exhibit pleiotropic effects. In particular, early flowering is frequently associated with reduced grain yield due to a shorter growth period. This trade‐off poses a major challenge for developing early‐maturing and high‐yielding varieties, a key breeding objective in modern maize production. Here, we demonstrate that
Shumin Wang, Junjie He, Lufei Zhang, Li Guo, Ruchang Ren, Xu Han, Lishuan Wu, Huayuan Zhang, Dezhi Deng, Xiangyang Guo, Fang Yang, Chenglong Wang, Feng Tian, Yameng Liang   +13 more
wiley   +1 more source

Insights from single-molecule force spectroscopy into chromatin topology. [PDF]

Biophys Rev
Daris LJC, Eeftens JM.
europepmc   +1 more source

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain‐Containing Proteins

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley   +1 more source

Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26. [PDF]

Nat Commun
Fukushima Y, Kinoshita C, Negishi L, Kujirai T, Kobayashi Y, Ogasawara M, Ehara H, Sekine SI, Kagawa W, Kurumizaka H, Takizawa Y.   +10 more
europepmc   +1 more source

Differential presence of neutrophil extracellular traps in serum vs plasma of patients with critical limb-threatening ischemia. [PDF]

Res Pract Thromb Haemost
Gendron N, Roche A, Granger V, Emmerich J, Sanchez O, Gaussem P, Smadja DM, de Chaisemartin L.   +7 more
europepmc   +1 more source

Combinatorial histone modifications direct ATP-dependent chromatin remodeling by NURF to promoter-proximal nucleosomes. [PDF]

Nucleic Acids Res
Kwon SY, Jang B, Grisan V, Liang Y, Reed MAC, Jung H, Lee YE, Halston R, Chan KH, Bottegoni G, Gunther UL, Wu C, Badenhorst P.   +12 more
europepmc   +1 more source

Altered benzo[a]pyrene adduct formation in nucleosomes establishes distinct mutational patterns in lung cancer. [PDF]

J Biol Chem
Morledge-Hampton B, Lindberg M, Larsson E, Wyrick JJ.   +3 more
europepmc   +1 more source