Results 161 to 170 of about 49,625 (309)
Nanoscale Characterization of Interaction of Nucleosomes with H1 Linker Histone
In eukaryotic nuclei, DNA is wrapped around an octamer of core histones to form nucleosomes. H1 binds to the linker DNA of nucleosome to form the chromatosome, the next structural unit of chromatin.
Filliaux, Shaun +5 more
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Technologies for engineering repetitive DNA
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley +1 more source
Glia, Volume 74, Issue 8, August 2026.Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez +8 more
wiley +1 more source
A Systematic Study of Nucleosome Core Particle and Nucleosome-Nucleosome Stacking Structure [PDF]
Biophysical Journal, 2018 Nikolay Korolev +2 more
openaire +1 more source
Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
Developmental Neurobiology, Volume 86, Issue 3, July 2026.ABSTRACT Although much is known about the encoding of experience, how the brain organizes neural circuits capable of learning and memory formation is largely unstudied. Canonical critical periods emerge from a convergence of maturation‐ and experience‐dependent processes.
Grant W. Kunzelman +2 more
wiley +1 more source
Physics-based nucleosome-resolution modeling of epigenetic-driven chromatin domain dynamics. [PDF]
Nucleic Acids ResGu C, Takada S, Brandani GB.
europepmc +1 more source
Single‐Cell CRISPR: An Efficient Strategy for Decoding Plant Cis‐Regulatory Complexity
Plant Biotechnology Journal, Volume 24, Issue 7, Page 4454-4467, July 2026.ABSTRACT The generation of complex traits involves the coordinated interplay of multiple gene networks. Elucidating the function of transcriptional cis‐regulatory elements (CREs) in regulating gene expression is crucial for understanding complex regulatory pathways and improving our ability to modify macro‐phenotypes.
Yuanhang Zhang +5 more
wiley +1 more source
Chemical biology tools for studying histone post-translational modifications. [PDF]
Cell Chem BiolDouglas CJ, Seath CP.
europepmc +1 more source
Enhanced DNA repair synthesis in hyperacetylated nucleosomes
We have investigated the level of 'early' DNA repair synthesis in nucleosome subpopulations, varying in histone acetylation, from normal human fibroblasts treated with sodium butyrate. We find that repair synthesis occurring during the first 30 min after
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