Results 181 to 190 of about 10,982 (239)
British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley +1 more source
The FEBS Journal, Volume 293, Issue 21, Page 6323-6348, November 2026.The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati +4 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 21, Page 6444-6466, November 2026.Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi +12 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 21, Page 6569-6585, November 2026.Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal +5 more
wiley +1 more source
Plant Biotechnology Journal, Volume 24, Issue 11, Page 5946-5966, November 2026.ABSTRACT The escalating frequency and intensity of recent droughts threaten global crop production and food security. Although drought priming is crucial for plant drought resilience, the mechanisms imparting drought stress memory remain poorly understood, especially in crops such as tomato. This study elucidates the mechanisms of drought stress memory
Rong Zhou +14 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu +19 more
wiley +2 more sources
Plant Biotechnology Journal, Volume 24, Issue 11, Page 6028-6044, November 2026.ABSTRACT Fruit size is not only a crucial fitness trait in plant evolution but also an important agronomic target in crop domestication and improvement, yet its regulatory mechanisms remain poorly characterized. Here, we identified an F‐box E3 ubiquitin ligase gene, GhEBS1 (ENLARGED BOLL SIZE 1), as a positive regulator of cotton boll size via map ...
Furong Wang +19 more
wiley +1 more source
Chromatin Remodelling Complexes in Plant Adaptation to Abiotic Stress: Mechanisms and Perspectives
Plant, Cell &Environment, Volume 49, Issue 11, Page 9117-9132, November 2026.ABSTRACT As sessile organisms, plants have evolved elaborate epigenetic regulatory networks to adapt to a wide range of abiotic stress. Chromatin remodelling is a core epigenetic regulatory mechanism that refers to the process by which chromatin remodelling complexes mediate dynamic changes in chromatin spatial conformation and DNA accessibility ...
Xiuxiu Zhang, Yueran Zhang, Jiang Li
wiley +1 more source
The Plant Journal, Volume 128, Issue 3, November 2026.Significance Statement We report a T2T genome of endangered Sinojackia xylocarpa, whose centromeres comprise diverse transposable element (TE) families, and identify a centromere‐like domain and inversion polymorphisms on the chr1 right arm. Small population genomic erosion weakens purifying selection and creates an evolutionary dilemma, underscoring ...
Si‐Di Liang +14 more
wiley +1 more source