Results 181 to 190 of about 49,625 (309)

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Nanoscale Mapping Reveals Periodic Organization of Neutrophil Extracellular Trap Proteins. [PDF]

Nano Lett
Winkler M, Mack TGA, Eickholt BJ, Schmoranzer J, Burn GL, Gimber N.   +5 more
europepmc   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, Volume 13, Issue 31, 4 June 2026.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Pervasive and programmed nucleosome distortion on single chromatin fibres. [PDF]

Nature
Yang MG, Richter HJ, Wang S, McNally CP, Moore CM, Emadi A, Harris NE, Dhillon S, Maresca M, Pan H, Saunders H, Yang R, Ostrowski MS, Anderson EC, de Wit E, Maher JJ, Fan Y, Narlikar GJ, Nora EP, Willenbring H, Goodarzi H, Ramani V.   +21 more
europepmc   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Viral nucleosome-like particles show increased dynamic behavior and altered thermodynamic stability. [PDF]

Biophys J
Melo ME, Wereszczynski J.
europepmc   +1 more source

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley   +1 more source

Chromatin context-dependent deacetylation by the asymmetric Rpd3L. [PDF]

Nucleic Acids Res
Zhao H, Li H, Wang C, Yang X, Zou B, Dong S, Zhang N, Zhou Y, Yi L, Zhang Y, Xie Y, Qin D, Chao WCH, Pei D, He J.   +14 more
europepmc   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Histone H2B-associated proteins: The Arabidopsis nucleolin 1 binds H2B and facilitates nucleosome disassembly via RNA-dependent mechanism. [PDF]

J Biol Chem
Yarra NK, Singiri JR, Agmon-Adler Z, Grandhi R, Sastya A, Novoplansky N, Grafi G.   +6 more
europepmc   +1 more source