Results 171 to 180 of about 10,982 (239)

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, Volume 13, Issue 61, 3 November 2026.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Toward a digital urinary biopsy for early risk stratification in diabetic kidney disease: Anchoring shed cells, vesicles, and cell‐free DNA to spatial kidney cell states

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
In diabetic kidney disease, one urine specimen carries shed cells, extracellular vesicles and cell‐free DNA released along the whole nephron. Reading all three against spatial kidney atlases is proposed as a testable route to cell‐resolved, non‐invasive risk stratification, and the clinical outputs shown are not yet demonstrated.
Juan Wu, Ping Sheng, Ying Lu, Ke Chen
wiley   +1 more source

Comparative Analysis of Exonic SSR‐Containing Genes in Three Diving Duck Species Reveals Shared Functional Themes

Ecology and Evolution, Volume 16, Issue 11, November 2026.
Comparative analysis of chromosome‐level genomes from three diving duck species revealed pronounced interspecific variation in genome‐wide SSR abundance and repeat composition, while identifying 4336 exonic SSR‐containing genes shared among all three species.
Jie Huang, Bo Yang, Jiayi Qiao, Huaming Zhong, Chengzhong Yang   +4 more
wiley   +1 more source

Lineage switch in childhood leukemia

HemaSphere, Volume 10, Issue 11, November 2026.
Abstract Lineage switch (LS) is a rare but aggressive immunophenotypic transformation of acute leukemia associated with limited therapeutic options and poor clinical outcome. Although LS has been increasingly recognized in the era of CD19‐directed immunotherapies, its biological basis remains incompletely understood.
Katharina Daugs, Anna Prazmo, Anindita Roy, Arndt Borkhardt   +3 more
wiley   +1 more source

Neointimal Hyperplasia and Restenosis: Epidemiology, Pathophysiology, Animal Models, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
The overall graphical diagram to summarize the pathological characteristics, pathogenesis, clinical manifestation, preclinical animal models, diagnostic methods, and intervention strategies for neointimal hyperplasia. Neointimal hyperplasia results from excessive proliferation and intimal migration of vascular smooth muscle cells (VSMCs) in the ...
Kaixu Wang, Daiyu Zhang, Yu Hu, Yixin Zhao, Xinling Wang, Long Jiang, Meixiu Jiang   +6 more
wiley   +1 more source

Liquid Biopsy: Past, Present, and Future

MedComm, Volume 7, Issue 11, November 2026.
Liquid biopsy has expanded from cancer genotyping to a broader strategy for probing both oncologic and nononcologic conditions through circulating analytes and multilayer molecular readouts. This review traces the field's past, present, and future—summarizing where liquid biopsy is most actionable today, why performance varies across contexts, and ...
Jiachen Liu, Dianjie Zeng, Keran Zhao, Yuxi Wang, Huijie Hu, Fei Deng, Yinhuai Wang, Liya Sun, Liangmin Fu   +8 more
wiley   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

Role of Sirtuins in the Hallmarks of Skin Aging

Aging Cell, Volume 25, Issue 11, November 2026.
In the skin, sirtuins support the integrity of the epidermis and dermis and protect the skin from environmental insults by maintaining cellular homeostasis. Sirtuins decline with chronological age, contributing to the biological hallmarks of aging, with increasing evidence emerging of their specific roles in skin aging.
Rishabh Kala, Antonella Rella, Whitby Eagle, Earl Goyarts, Jian Cao, Binwei Deng, Kelly Dong, Chloe Schmit, Matthew Cappock, Krystle Corallo, Jacqueline Trivero   +10 more
wiley   +1 more source

A 209‐Site DNA Methylation Predictor of Chronological Age Evaluated Under Empirical and Random Missingness

Aging Cell, Volume 25, Issue 11, November 2026.
A stability‐selected 209‐CpG panel with nearest‐neighbor reconstruction supports chronological‐age prediction from incomplete blood methylation profiles. In held‐out samples under empirically derived missingness masks, reconstruction reduced root‐mean‐square error by 0.365 years versus mean replacement, with larger benefits at higher missingness ...
Xiangteng Zhao, Yanhong Lu, Biqing Huang, Zijie Wang, Tong Yu, Ruoqi Zhao, Shiwen Yu, Shushan Wei, Yeting Zeng   +8 more
wiley   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source