Results 171 to 180 of about 49,625 (309)

Comprehensive Biophysical Profiling Evidences Self‐Oligomerization of Bacterially Expressed Pc Protein

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Polycomb (Pc), a core component of Polycomb Repressive Complex 1 (PRC1), is largely intrinsically disordered yet forms buffer‐ and concentration‐dependent higher‐order assemblies. Integrative biophysical analysis and cryo‐electron microscopy reveal dynamic, heterogeneous oligomers, whereas AlphaFold modeling suggests that structural organization is ...
Maria Zahid, Sabin Prajapati, Ghazaleh Alamdari, Kai Tittmann, Selin Kara   +4 more
wiley   +1 more source

DNA-histone cross-link locks the nucleosome structure and disrupts its recognition and processing. [PDF]

Protein Cell
Shan X, Ji G, Li J, Ren M, Ma J, Zhou Y, Li H, Zhou C.   +7 more
europepmc   +1 more source

KAS‐Seq Captures Global Transcription Dynamics and Active Single‐Stranded Enhancers in Rice

Plant Biotechnology Journal, EarlyView.
Haoxuan Li, Xuling Li, Kayla He, Hua Dang, Wei Shen, Pingxian Zhang, Chuan He, Guanqun Wang   +7 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, Volume 16, Issue 6, Page 1213-1221, June 2026.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Histone modification cross-talk: analytical tools and molecular mechanisms. [PDF]

Biochem J
Jiang J, DuBois-Coyne S, Nam E, Whedon SD, Lee K, Cole PA.   +5 more
europepmc   +1 more source

The centromeric nucleosome and the fiber of nucleosomes

, 2007
In this report, I presented the results I obtained during the time I spent in the laboratory of Biochimie de la chromatine, often in collaboration with others laboratories in France, in Ukraine and the United States.Two questions interested me most:Structure and function of the centromeric nucleosome.
openaire   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, Volume 16, Issue 6, Page 1166-1180, June 2026.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Contributions of DNA mechanics and trans-regulation to nucleosome positioning in Schizosaccharomyces pombe and its role in co-transcriptional splicing. [PDF]

Epigenetics Chromatin
Liu G, Cang J, Du Z, Cui X, Zhao H, Liu J.   +5 more
europepmc   +1 more source

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

MeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation. [PDF]

Nat Commun
Watson JA, Alexander-Howden BK, Hall TS, Wear MA, McGhie F, Clifford G, Wapenaar H, Zou J, Bird A, Wilson MD.   +9 more
europepmc   +1 more source