Results 191 to 200 of about 42,592 (238)
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Nature Reviews Genetics, 2018
Two new studies in Nature provide insight into the role of nucleosomes in gene regulation. One describes the genome-wide organization of nucleosomes and the other details how transcription factor binding to DNA is affected by the presence of nucleosomes.
Clyde Dorothy
exaly +3 more sources
Two new studies in Nature provide insight into the role of nucleosomes in gene regulation. One describes the genome-wide organization of nucleosomes and the other details how transcription factor binding to DNA is affected by the presence of nucleosomes.
Clyde Dorothy
exaly +3 more sources
Nucleosome Mobility and the Maintenance of Nucleosome Positioning
Science, 1997To study nucleosome mobility and positioning, the R3 lac repressor was used with an adenosine triphosphate (ATP)–dependent chromatin assembly system to establish the positioning of five nucleosomes, with one nucleosome located between two R3 lac operators. When R3 protein was dissociated from
M J, Pazin +3 more
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Biochemical Society Symposia, 2006
In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent
Chris, Stockdale +7 more
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In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent
Chris, Stockdale +7 more
openaire +2 more sources
Lupus, 2002
Drs Berden and Koutouzov presented evidence that nucleosomes are antigens in lupus pathogenesis and that apoptotic cells are the source of nucleosomes. Berden's group measured persistence of circulating nucleosomes and nucleosome–antibody complexes in autoimmune mice and demonstrated nucleosomaldepositionin skin of SLE patientsas well as in renal ...
B D, Stollar, F, Stephenson
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Drs Berden and Koutouzov presented evidence that nucleosomes are antigens in lupus pathogenesis and that apoptotic cells are the source of nucleosomes. Berden's group measured persistence of circulating nucleosomes and nucleosome–antibody complexes in autoimmune mice and demonstrated nucleosomaldepositionin skin of SLE patientsas well as in renal ...
B D, Stollar, F, Stephenson
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Nature, 1980
Histones and DNA can spontaneously associate to form the nucleosome subunits of eukaryotic chromatin, but two proteins which occur in the eukaryotic nucleus can facilitate nucleosome assembly and greatly extend the conditions which permit assembly to occur.
R A, Laskey, W C, Earnshaw
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Histones and DNA can spontaneously associate to form the nucleosome subunits of eukaryotic chromatin, but two proteins which occur in the eukaryotic nucleus can facilitate nucleosome assembly and greatly extend the conditions which permit assembly to occur.
R A, Laskey, W C, Earnshaw
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Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1978
Abstract Electron microscopic and biochemical results are presented supporting the following conclusions: (1) Two molecules of each histone H2A, H2B, H3 and H4 are necessary and sufficient to form a nucleosome with a diameter of 12.5± 1 nm and containing about 200 base pairs of DNA.
P, Oudet +4 more
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Abstract Electron microscopic and biochemical results are presented supporting the following conclusions: (1) Two molecules of each histone H2A, H2B, H3 and H4 are necessary and sufficient to form a nucleosome with a diameter of 12.5± 1 nm and containing about 200 base pairs of DNA.
P, Oudet +4 more
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Remodeling and Repositioning of Nucleosomes in Nucleosomal Arrays
2018ATP-dependent nucleosome remodeling factors sculpt the nucleosomal landscape of eukaryotic chromatin. They deposit or evict nucleosomes or reposition them along DNA in a process termed nucleosome sliding. Remodeling has traditionally been analyzed using mononucleosomes as a model substrate.
Johanna, Ludwigsen +4 more
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Cell, 1988
Revue sommaire sur la structure du nucleosome et particulierement les aspects de cette structure qui vraisemblablement influencent les interactions des proteines avec le DNA ...
R H, Morse, R T, Simpson
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Revue sommaire sur la structure du nucleosome et particulierement les aspects de cette structure qui vraisemblablement influencent les interactions des proteines avec le DNA ...
R H, Morse, R T, Simpson
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Science, 2017
Both DNA and histones flex to undergo ...
Flaus, Andrew, Owen-Hughes, Tom
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Both DNA and histones flex to undergo ...
Flaus, Andrew, Owen-Hughes, Tom
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Phylogenomics of the nucleosome
Nature Structural & Molecular Biology, 2003Histones are best known as the architectural proteins that package the DNA of eukaryotic organisms, forming octameric nucleosome cores that the double helix wraps tightly around. Although histones have traditionally been viewed as slowly evolving scaffold proteins that lack diversification beyond their abundant tail modifications, recent studies have ...
Harmit S, Malik, Steven, Henikoff
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