Results 201 to 210 of about 49,625 (309)

Mechanisms of DNA methyltransferase 3A1-mediated DNA methylation of nucleosomes. [PDF]

J Biol Chem
Ward E, McDonald D, Holl T, Reich N.
europepmc   +1 more source

Cytogenetic and Molecular Analysis of a “Double‐Hit” RUNX1 Including a RUNX1 p.Trp279* and a Cryptic Novel t(6;21)(q25;q22)/RUNX1::ARID1B in Acute Myeloid Leukemia

Genes, Chromosomes and Cancer, Volume 65, Issue 6, June 2026.
ABSTRACT Introduction Alterations involving RUNX1 are recurrent in hematologic malignancies and contribute to disease pathogenesis via dysregulation of transcriptional factors essential for hematopoiesis. Here, we report an acquired alteration in both alleles of RUNX1; one is a truncating mutation and the second is a novel RUNX1::ARID1B identified in ...
Rolando García, Jing Xu, Lan Yu, Kalayarasan Srinivasan, Sharon Koorse Germans, Olga Weinberg, Franklin Fuda, Weina Chen, Prasad Koduru   +8 more
wiley   +1 more source

Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26. [PDF]

Nat Commun
Fukushima Y, Kinoshita C, Negishi L, Kujirai T, Kobayashi Y, Ogasawara M, Ehara H, Sekine SI, Kagawa W, Kurumizaka H, Takizawa Y.   +10 more
europepmc   +1 more source

A RiboCancer cell line panel reveals that CLL‐associated Rps15 mutations translationally rewire transcription through codon‐specific tRNA accommodation defects

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Recurrent point mutations in ribosomal proteins (RPs) RPL10 and RPS15 are found in T‐cell acute lymphoblastic leukemia (T‐ALL) and chronic lymphocytic leukemia (CLL), respectively. Furthermore, deletions of RPL5, RPL11, and RPL22 are frequent in hematologic diseases such as Diamond Blackfan Anemia, T‐ALL, multiple myeloma, and in a variety of ...
Anaïs Astier, Marino Caruso, Stijn Vereecke, Paulo E. Santo, Coralie Capron, Carine Froment, Dana Rinaldi, David Cabrerizo Granados, Marine Leclercq, Jonathan Royaert, Jelle Verbeeck, Naomy Pasau, Laura Plassart, Daniele Pepe, Steven Verbruggen, Hermes Paraqindes, Simon Lebaron, Virginie Marcel, Sébastien Durand, Clément Chapat, Gerben Menschaert, Pierre Close, Francesca Rapino, Frédéric Catez, Julien Marcoux, Célia Plisson‐Chastang, Kim De Keersmaecker   +26 more
wiley   +1 more source

Insights from single-molecule force spectroscopy into chromatin topology. [PDF]

Biophys Rev
Daris LJC, Eeftens JM.
europepmc   +1 more source

Combinatorial histone modifications direct ATP-dependent chromatin remodeling by NURF to promoter-proximal nucleosomes. [PDF]

Nucleic Acids Res
Kwon SY, Jang B, Grisan V, Liang Y, Reed MAC, Jung H, Lee YE, Halston R, Chan KH, Bottegoni G, Gunther UL, Wu C, Badenhorst P.   +12 more
europepmc   +1 more source

Differential presence of neutrophil extracellular traps in serum vs plasma of patients with critical limb-threatening ischemia. [PDF]

Res Pract Thromb Haemost
Gendron N, Roche A, Granger V, Emmerich J, Sanchez O, Gaussem P, Smadja DM, de Chaisemartin L.   +7 more
europepmc   +1 more source

Roles of histone lysine methylation in neurodevelopment and related disorders

Ibrain, Volume 12, Issue 2, Page 201-221, Summer 2026.
This graphical abstract centers on the theme of dynamic balance and systematically outlines the role of histone lysine methylation in neurodevelopment and related disorders. The figure first presents two key classes of regulators that control this balance—“writers” and “erasers”—and then indicates how interactions among different epigenetic ...
Yun Chen, Yi Zhang, Hong Zhang, Xiaoli Liang   +3 more
wiley   +1 more source

H2A.Z facilitates Sox2-nucleosome interaction by promoting DNA and histone H3 tail mobility. [PDF]

Nucleic Acids Res
Moos HK, Patel R, Flaherty SK, Loverde SM, Nikolova EN.   +4 more
europepmc   +1 more source

Extracellular Vesicles in the Biology and Liquid Biopsy Diagnostics of Pediatric High‐Grade Glioma – Emerging Findings and Opportunities

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Liquid biopsy has emerged as an important diagnostic paradigm impacting care across multiple cancer indications. This is also an area of great interest in pediatric solid tumours, including those affecting the central nervous system (CNS). Of special concern are pediatric high‐grade gliomas (pHGGs) due to the associated diagnostic complexities,
Samia Jahouri, Laura Montermini, Nadim Tawil, Mahsa Jalali, Livia Garzia, Nada Jabado, Janusz Rak   +6 more
wiley   +1 more source