Results 221 to 230 of about 49,625 (309)

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Nucleosome spacing across cell types, diseases, and ages. [PDF]

Nucleic Acids Res
Bikova M, Clarkson CT, Teif VB.
europepmc   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites. [PDF]

Elife
Kumar Y, Sengupta D, Friman ET, Illingworth RS, Soleil M, Fan Z, Wang H, Helin K, Gérard M, Bickmore WA.   +9 more
europepmc   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Direct visualization and tracing of chromatin folding in the Drosophila embryo. [PDF]

EMBO J
Fatmaoui F, Carrivain P, Taiki F, Iusupova A, Grewe D, Hagen W, Jakob B, Victor JM, Leforestier A, Eltsov M.   +9 more
europepmc   +1 more source

CHD4 Orchestrates Chromatin Remodeling to Activate the c‐Myc Signaling Pathway in Cancer Pathogenesis

MedComm – Oncology, Volume 5, Issue 2, June 2026.
CHD4 plays an essential role as an epigenetic regulator in the pathogenesis of multiple myeloma. The chromatin remodeling protein initially resolves G‐quadruplex (G4) secondary structures within the c‐Myc promoter region, thereby enhancing chromatin accessibility and promoting transcriptional activation.
Pinggang Ding, Yuhao Cao, Zihao Liu, Jingru Xie, Lingling Liu, Shanliang Sun, Xichao Yu, Zhendong Deng, Zhimin Fan, Ye Yang, Chunyan Gu   +10 more
wiley   +1 more source

Recognition and remodelling of nucleosomes and hexasomes by the human INO80 complex. [PDF]

Nucleic Acids Res
Aggarwal P, Sharma M, Woike S, Kunert F, Brem A, Moldt M, Hopfner KP.   +6 more
europepmc   +1 more source

Nucleosome [PDF]

, 2019
openaire   +1 more source