Results 141 to 150 of about 42,592 (238)

Chromatin context-dependent deacetylation by the asymmetric Rpd3L. [PDF]

Nucleic Acids Res
Zhao H, Li H, Wang C, Yang X, Zou B, Dong S, Zhang N, Zhou Y, Yi L, Zhang Y, Xie Y, Qin D, Chao WCH, Pei D, He J.   +14 more
europepmc   +1 more source

A molecular landscape and prognosis signature based on histone tyrosine sulfation in pan‐cancer analysis

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
A pan‐cancer transcriptional signature based on histone tyrosine sulfation (HYsulf) reveals associations with immune infiltration, metabolic reprogramming and patient prognosis, thereby enabling the development of predictive nomograms for PCPG and UVM.
Meijuan Cai, Yuhao Liao, Jun Lin, Xumeng Chen, Jiale Wang, Zhijuan Li, Zhengjun Yang, DianKui Cai   +7 more
wiley   +1 more source

Histone H2B-associated proteins: The Arabidopsis nucleolin 1 binds H2B and facilitates nucleosome disassembly via RNA-dependent mechanism. [PDF]

J Biol Chem
Yarra NK, Singiri JR, Agmon-Adler Z, Grandhi R, Sastya A, Novoplansky N, Grafi G.   +6 more
europepmc   +1 more source

Single‐Nucleus Multiomic Analysis Reveals Immune–Metabolic Reprogramming Consistent With Maladaptive Trained Immunity in HIV‐Associated Neurocognitive Disorders

Glia, Volume 74, Issue 8, August 2026.
Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez, Anelia Horvath, Luke Johnson, Tatiana Pushkarsky, Larisa Dubrovsky, Daria Starosyla, Ashley Bastin, Dmitri Sviridov, Michael Bukrinsky   +8 more
wiley   +1 more source

SM-NucSeq, Genetic and Epigenetic Sequencing of Nucleosomes with Single-Molecule Real-Time Sequencing. [PDF]

Nano Lett
Zheng P, Furth N, O'Leary SE, Shema E, Wanunu M.   +4 more
europepmc   +1 more source

Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Diabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.
Kenshi Yoshimura, Yuya Kiriake, Hiroki Osanai, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Masaki Morishima, Ryusuke Suzuki, Shinji Miyamoto, Katsushige Ono   +9 more
wiley   +1 more source

Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells. [PDF]

Sci Adv
Shimazoe MA, Huertas J, Phillips C, Ide S, Tamura S, Farr S, Ashwin SS, Sasai M, Collepardo-Guevara R, Maeshima K.   +9 more
europepmc   +1 more source

An unattended image‐processing pipeline for on‐the‐fly quality assessment and 3D exploration in cryo‐EM

Acta Crystallographica Section D, Volume 82, Issue 8, Page 915-939, August 2026.
We present a fully automated, unattended cryo‐EM pipeline that serves as an on‐the‐fly diagnostic tool, enabling rapid data‐quality assessment and informed decision‐making to maximize data‐collection efficiency.Single‐particle analysis (SPA) by cryogenic electron microscopy (cryo‐EM) has become a cornerstone of structural biology; yet, the workflow ...
Daniel Marchán Torres, Pablo Conesa, Alberto Garcia, Mikel Iceta, Ludovic Broche, Marcos Gragera, Romain Linares, Hok Sau Kwong, Francisco Javier Chichón, Olof Svensson, Rocío Arranz, Grégory Effantin, Eaazhisai Kandiah, José María Carazo, Carlos O. S. Sorzano   +14 more
wiley   +1 more source

Mechanisms of DNA methyltransferase 3A1-mediated DNA methylation of nucleosomes. [PDF]

J Biol Chem
Ward E, McDonald D, Holl T, Reich N.
europepmc   +1 more source

Blocking SETD2 Enhances the Therapeutic Efficiency of Menin Inhibitor in MLL‐Fusion Leukemia

Cancer Science, Volume 117, Issue 8, Page 2221-2235, August 2026.
Combined SETD2 and menin inhibitors make synergistic effects against MLL‐fusion leukemia; the combination therapy reduces the expression of target genes through blocking transcription elongation and initiation. ABSTRACT During transcriptional elongation, the histone methyltransferase SETD2 binds to RNA polymerase II and deposits trimethylation marks at
Anpei Li, Yuan Zhang, Ziwei Li, Anhao Liu, Li Zhang, Shubin Gao, Xiao Lin, Xiaoming Liu, Huan Li, Guanghui Jin, Bin Xu   +10 more
wiley   +1 more source