Results 141 to 150 of about 109,383 (351)

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

The physics of epigenetics

, 2016
In higher organisms, all cells share the same genome, but every cell expresses only a limited and specific set of genes that defines the cell type. During cell division, not only the genome, but also the cell type is inherited by the daughter cells. This
Barbi, Maria, Caré, Bertrand R., Cortini, Ruggero, Lavelle, Christophe, Lesne, Annick, Mozziconacci, Julien, Victor, Jean-Marc   +6 more
core   +3 more sources

The octamer is the major form of CENP-A nucleosomes at human centromeres

Nature Structural &Molecular Biology, 2013
The centromere is the chromosomal locus that ensures fidelity in genome transmission at cell division. Centromere protein A (CENP-A) is a histone H3 variant that specifies centromere location independently of DNA sequence.
Dan Hasson, Tanya Panchenko, Kevan J. Salimian, M. U. Salman, N. Sekulić, A. Alonso, P. Warburton, B. E. Black   +7 more
semanticscholar   +1 more source

Apoptotic Release of Histones from Nucleosomes [PDF]

, 2002
DongCheng Wu, Alistair J. Ingram, Jill H. Lahti, Brie Mazza, José Grenet, Anil Kapoor, Lieqi Liu, Vincent J. Kidd, Damu Tang   +8 more
openalex   +1 more source

Bioanalytical TERS and Advanced Data Processing Methods

Journal of Raman Spectroscopy, EarlyView.
Tip‐enhanced Raman spectroscopy delivers label‐free, subnanometer vibrational imaging of biological systems. Recent advances in instrumentation, data analysis, and ambient/liquid operation enable surface‐selective mapping of molecular heterogeneity in proteins, nucleic acids, membranes, and viruses, positioning TERS as a powerful platform for nanoscale
Sarika Joshi, Ankit Dodla, Sarthak Saxena, Twinkle Soni, Sumit Saxena, Shobha Shukla, Bayden R. Wood   +6 more
wiley   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Polymer reptation and nucleosome repositioning

, 2001
We consider how beads can diffuse along a chain that wraps them, without becoming displaced from the chain; our proposed mechanism is analogous to the reptation of "stored length" in more familiar situations of polymer dynamics. The problem arises in the
D. Keller, G. Meersseman, H. Schiessel, H. Schiessel, J. F. Marko, J. Widom, J. Widom, J. Widom, K. J. Polach, K. J. Polach, K. Luger, P. G. de Gennes, R. D. Kornberg, R. F. Bruinsma, S. A. Sukhishvili, S. Pennings, V. M. Studitsky, W. M. Gelbart, Y. Lorch   +18 more
core   +2 more sources

Transcription-generated torsional stress destabilizes nucleosomes

Nature Structural &Molecular Biology, 2013
As RNA polymerase II (Pol II) transcribes a gene, it encounters an array of well-ordered nucleosomes. How it traverses through this array in vivo remains unresolved.
Sheila S. Teves, S. Henikoff
semanticscholar   +1 more source

Liquid Biopsy Differentiation of Pancreatic Cancer From Non‐Cancerous Pancreatic Disease Using Dielectrophoresis‐Recovered Nanoparticles Carrying Cell‐Free DNA and Protein Biomarkers

Small, EarlyView.
A new nanoparticle‐based biomarker panel is described that can differentiate pancreatic cancer from benign pancreatic disease with a high level of performance. This was enabled by microelectrode array recovery technology that used dielectrophoresis (DEP) to quickly and efficiently recover the nanoparticles from patient plasma samples, followed by on ...
Anna Malakian, Augusta Modestino, Jesus Bueno, Archana Machireddy, Jason Ware, Sean Hamilton, Ella Stimson, Sarah Mitchell, Joshua C. Saldivar, Ashley R. Woodfin, Corey M. Dambacher, Kyle Gustafson, Delaney Shea, Srivathsan Ranganathan, Mehrzad Sasanpour, Christian Ross, Dove Keith, Jeong Youn Lim, Xubo Song, Scott M. Lippman, Rosalie Sears, Terry Morgan, Michael Heller, Stuart D. Ibsen   +23 more
wiley   +1 more source

Histone Tail Dynamics in Partially Disassembled Nucleosomes During Chromatin Remodeling

Frontiers in Molecular Biosciences, 2019
Nucleosomes are structural units of the chromosome consisting of DNA wrapped around histone proteins, and play important roles in compaction and regulation of the chromatin structure.
Takeru Kameda, Akinori Awazu, Akinori Awazu, Yuichi Togashi, Yuichi Togashi, Yuichi Togashi   +5 more
doaj   +1 more source