Results 71 to 80 of about 10,982 (239)
, 2015 A. and B The nucleosome signal is shown in the region covering the gene for DNA polymerase (UL30) and its processivity factor (UL41). There is one copy of these genes located in the unique long segment of the viral gene.
Hongzhe Li (26250) +9 more
core +1 more source
Mutations to the histone H3 alpha N region selectively alter the outcome of ATP-dependent nucleosome-remodelling reactions [PDF]
, 2009 Mutational analysis of the histone H3 N-terminal region has shown it to play an important role both in chromatin function in vivo and nucleosome dynamics in vitro.
Owen-Hughes, Tom; id_orcid +1 more
core +1 more source
RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites
Advanced Science, EarlyView.At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo +10 more
wiley +1 more source
NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment
Advanced Science, EarlyView.The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou +6 more
wiley +1 more source
Cell GenomicsSummary: Deep learning models have advanced our ability to predict cell-type-specific chromatin patterns from transcription factor (TF) binding motifs, but their application to perturbed contexts remains limited.
Sahin Naqvi +6 more
doaj +1 more source
Job Opening for Nucleosome Mechanic: Flexibility Required
Cells, 2020 The nucleus has been studied for well over 100 years, and chromatin has been the intense focus of experiments for decades. In this review, we focus on an understudied aspect of chromatin biology, namely the chromatin fiber polymer’s mechanical ...
Mary Pitman +2 more
doaj +1 more source
A subset of nucleosomes demonstrate behaviors specific to H3 depletion.
, 2012 (A) Schematic representation of the nucleosome classification method. Nucleosomes were classified based on changes in center positions and changes in read center counts between 0 hours and 3 hours (Materials and Methods).
Jason D. Lieb (135330) +1 more
core +1 more source
Advanced Science, EarlyView.In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang +11 more
wiley +1 more source
Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis
Current Issues in Molecular BiologyCellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta +5 more
doaj +1 more source
Transcriptionally Driven DNA Replication Program of the Human Parasite Leishmania major
Cell Reports, 2016 Faithful inheritance of eukaryotic genomes requires the orchestrated activation of multiple DNA replication origins (ORIs). Although origin firing is mechanistically conserved, how origins are specified and selected for activation varies across different
Rodrigo Lombraña +8 more
doaj +1 more source