Results 71 to 80 of about 49,625 (309)

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Transfer learning reveals sequence determinants of the quantitative response to transcription factor dosage

Cell Genomics
Summary: Deep learning models have advanced our ability to predict cell-type-specific chromatin patterns from transcription factor (TF) binding motifs, but their application to perturbed contexts remains limited.
Sahin Naqvi, Seungsoo Kim, Saman Tabatabaee, Anusri Pampari, Anshul Kundaje, Jonathan K. Pritchard, Joanna Wysocka   +6 more
doaj   +1 more source

Job Opening for Nucleosome Mechanic: Flexibility Required

Cells, 2020
The nucleus has been studied for well over 100 years, and chromatin has been the intense focus of experiments for decades. In this review, we focus on an understudied aspect of chromatin biology, namely the chromatin fiber polymer’s mechanical ...
Mary Pitman, Daniël P. Melters, Yamini Dalal   +2 more
doaj   +1 more source

Average final fraction of nucleosomes vs. the number of initial nucleosomes.

, 2013
The average final fraction of nucleosomes is plotted as a function of (the number of initial nucleosomes) for (, ) being (0.003, 0.0015)(red) and (0.005, 0.0025)(blue).
Edward Ott (180528), Guo-Cheng Yuan (39064), Francesco Sorrentino (479016), Michelle Girvan (180524), Wai Lim Ku (180517)   +4 more
core   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis

Current Issues in Molecular Biology
Cellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta, Sauradeep Dutta, Payaningal R. Somanath, S. Priya Narayanan, Xiaoyun Wang, Duo Zhang   +5 more
doaj   +1 more source

Proximal-end bias from in-vitro reconstituted nucleosomes and the result on downstream data analysis.

PLoS ONE, 2021
The most basic level of eukaryotic gene regulation is the presence or absence of nucleosomes on DNA regulatory elements. In an effort to elucidate in vivo nucleosome patterns, in vitro studies are frequently used.
David A Bates, Charles E Bates, Andrew S Earl, Colin Skousen, Ashley N Fetbrandt, Jordon Ritchie, Paul M Bodily, Steven M Johnson   +7 more
doaj   +1 more source

Characterisation of CenH3 nucleosomes [PDF]

, 2013
As a centromere-specific protein complex in direct contact with the DNA, CenH3-containing nucleosomes are generally thought to act as the distinguishing epigenetic mark of active centromere location.
Miell, Matthew Daniel David
core  

Asymmetrically Modified Nucleosomes

, 2012
SummaryMononucleosomes, the basic building blocks of chromatin, contain two copies of each core histone. The associated posttranslational modifications regulate essential chromatin-dependent processes, yet whether each histone copy is identically ...
LeRoy, Gary, Beck, David B., Zee, Barry M., Garcia, Benjamin A., Reinberg, Danny, Son, Jinsook, Drury, William J., Voigt, Philipp, Young, Nicolas L.   +8 more
core   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source