Results 51 to 60 of about 49,625 (309)

LPS-Challenged Macrophages Release Microvesicles Coated With Histones

Frontiers in Immunology, 2018
Histones are the protein component of nucleosomes, which are the basic packing unit of chromatin. However, histones are also found in the blood, both as components of nucleosomes leaked out from dead cells, or expelled from neutrophils in the active ...
Rohini Ravindran Nair, Davide Mazza, Francesca Brambilla, Andrea Gorzanelli, Alessandra Agresti, Marco E. Bianchi   +5 more
doaj   +1 more source

Life Cycle Stage-Specific Accessibility of Leishmania donovani Chromatin at Transcription Start Regions

mSystems, 2021
Leishmania donovani is a parasitic protist that causes the lethal Kala-azar fever in India and East Africa. Gene expression in Leishmania is regulated by gene copy number variation and inducible translation while RNA synthesis initiates at a small number
Janne Grünebast, Stephan Lorenzen, Julia Zummack, Joachim Clos   +3 more
doaj   +1 more source

Dynamic Remodeling of Individual Nucleosomes Across a Eukaryotic Genome in Response to Transcriptional Perturbation

, 2008
Sushma Shivaswamy is with UT Austin, Akshay Bhinge is with UT Austin, Yongjun Zhao is with British Columbia Cancer Agency, Steven Jones is with British Columbia Cancer Agency, Martin Hirst is with British Columbia Cancer Agency, Vishwanath R Iyer is with
Bhinge, Akshay, Vishwanath R Iyer, Zhao Yongjun, Iyer Vishwanath R, Shivaswamy Sushma, Iyer, Vishwanath R, Shivaswamy, Sushma, Jones Steven, Zhao, Yongjun, Yongjun Zhao, Jones, Steven, Martin Hirst, Bhinge Akshay, Steven Jones, Akshay Bhinge, Hirst, Martin, Sushma Shivaswamy, Hirst Martin   +17 more
core   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Nucleosomes impede Cas9 access to DNA in vivo and in vitro

eLife, 2016
The prokaryotic CRISPR (clustered regularly interspaced palindromic repeats)-associated protein, Cas9, has been widely adopted as a tool for editing, imaging, and regulating eukaryotic genomes.
Max A Horlbeck, Lea B Witkowsky, Benjamin Guglielmi, Joseph M Replogle, Luke A Gilbert, Jacqueline E Villalta, Sharon E Torigoe, Robert Tjian, Jonathan S Weissman   +8 more
doaj   +1 more source

Electrophoresis of Positioned Nucleosomes [PDF]

Biophysical Journal, 2007
to appear in Biophys. J.
Castelnovo, Martin, Grauwin, Sébastian
openaire   +3 more sources

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Making better CRISPR libraries

eLife, 2016
A new algorithm improves the performance of CRISPR-based genetic screens in mammals.
Shiyou Zhu, Wensheng Wei
doaj   +1 more source

Mechanical properties of nucleoprotein complexes determined by nanoindentation spectroscopy

Nucleus, 2020
The interplay between transcription factors, chromatin remodelers, 3-D organization, and mechanical properties of the chromatin fiber controls genome function in eukaryotes.
Tatini Rakshit, Daniël P. Melters, Emilios K. Dimitriadis, Yamini Dalal   +3 more
doaj   +1 more source

Nucleosomes and Cisplatin

Chemistry & Biology, 2010
In order to form a covalent complex with DNA inside human cells, cisplatin has to overcome the protective environment of a nucleosome, where DNA is complexed with histone proteins. Todd and Lippard (2010) expand our understanding of this process by describing the structure of a nucleosome containing a Pt-DNA adduct, which has important implications for
openaire   +2 more sources