Results 51 to 60 of about 10,982 (239)
Ctf4 organizes sister replisomes and Pol α into a replication factory
eLife, 2019 The current view is that eukaryotic replisomes are independent. Here we show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol α-primase.
Zuanning Yuan +8 more
doaj +1 more source
Nucleosome packaging and nucleosome positioning of genomic DNA [PDF]
Proceedings of the National Academy of Sciences, 1997 The goals of this study were to assess the extent to which bulk genomic DNA sequences contribute to their own packaging in nucleosomes and to reveal the relationship between nucleosome packaging and positioning. Using a competitive nucleosome reconstitution assay, we found that at least 95% of bulk DNA sequences have an affinity ...
P T, Lowary, J, Widom
openaire +2 more sources
Electrophoresis of Positioned Nucleosomes [PDF]
Biophysical Journal, 2007 to appear in Biophys. J.
Castelnovo, Martin, Grauwin, Sébastian
openaire +4 more sources
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Average final fraction of nucleosomes vs. the number of initial nucleosomes.
, 2013 The average final fraction of nucleosomes is plotted as a function of (the number of initial nucleosomes) for (, ) being (0.003, 0.0015)(red) and (0.005, 0.0025)(blue).
Edward Ott (180528) +4 more
core +1 more source
Plasma Nucleosomes in Primary Breast Cancer
, 2020 When cells die, nucleosomes composed of DNA and histone proteins enter the extracellular space and end eventually in the circulation. In plasma, they might serve as a nonspecific marker of cell death, potentially useful for noninvasive monitoring of ...
Gabriel Minarik +10 more
core +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Characterisation of CenH3 nucleosomes [PDF]
, 2013 As a centromere-specific protein complex in direct contact with the DNA, CenH3-containing nucleosomes are generally thought to act as the distinguishing epigenetic mark of active centromere location.
Miell, Matthew Daniel David
core +3 more sources
Nucleosomes and epigenetics from a chemical perspective [PDF]
, 2021 Nucleosomes, which are the fundamental building blocks of chromatin, are highly dynamic and play vital roles in the formation of higher‐order chromatin structures and orchestrate gene regulation.
Hiroshi Sugiyama +5 more
core +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source