Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia
Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1196-1205, June 2026.ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa +10 more
wiley +1 more source
Purine and pyrimidine nucleotide metabolism in Mollicutes
Genetics and Molecular Biology, 2007 Several mollicute genome projects are underway, offering unique opportunities to study genes and metabolic pathways on a genome-wide scale. Here, we have analyzed the conservation and diversity of purine and pyrimidine metabolism in mycoplasmas.
Cristiano Valim Bizarro +1 more
doaj +1 more source
CD73 is a major regulator of adenosinergic signalling in mouse brain.
PLoS ONE, 2013 CD73 (ecto-5'-nucleotidase) is a cell surface enzyme that regulates purinergic signalling by desphosphorylating extracellular AMP to adenosine. 5'-nucleotidases are known to be expressed in brain, but the expression of CD73 and its putative physiological
Natalia Kulesskaya +6 more
doaj +1 more source
Ecto-nucleotidases activities in the contents of ovarian endometriomas: potential biomarkers of endometriosis [PDF]
Endometriosis, defined as the growth of endometrial tissue outside the uterus, is a common gynecologic condition affecting millions of women worldwide. It is an inflammatory, estrogen-dependent complex disorder, with broad symptomatic variability, pelvic
Texidó, Laura +9 more
core
Contribution of cytosolic and membrane-bound 5'-nucleotidases to cardiac adenosine production [PDF]
, 1996 The purpose of this study was to evaluate the relative contributions of AMP-specific cytosolic 5'-nucleotidase and ecto-5'-nucleotidase to cardiac adenosine production and its regulation by ADP and Mg2+.
P. J. Metting +3 more
core +1 more source
ENTPDase inhibitors: therapeutic potential in infectious, inflammatory, and neuroinflammatory diseases [PDF]
Exploration of NeuroscienceEctonucleoside triphosphate diphosphohydrolases (ENTPDases), members of the cluster of differentiation 39 (CD39) family, are key regulators of purinergic signaling through the hydrolysis of tri and diphosphate nucleotides.
Isadora Cunha Ribeiro +4 more
doaj +1 more source
Nucleotidases e depressão: efeito de fármacos antidepressivos no catabolismo do ATP extracelular [PDF]
, 2007 Depression is the most common manifestation of affective disorders. It is one of the most disable diseases, and causes a significant burden to both the individual and the society and, if not treated, it can increase morbidity and mortality.
Pedrazza, Eduardo Luiz
core
Hypotensive Snake Venom Components—A Mini-Review
Molecules, 2019 Hypertension is considered a major public health issue due to its high prevalence and subsequent risk of cardiovascular and kidney diseases. Thus, the search for new antihypertensive compounds remains of great interest.
Orsolya Péterfi +4 more
doaj +1 more source
Nucleotidases e depress?o : efeito de f?rmacos antidepressivos no catabolismo do ATP extracelular [PDF]
, 2007 Made available in DSpace on 2015-04-14T14:51:38Z (GMT). No. of bitstreams: 1 391140.pdf: 3891847 bytes, checksum: a692cff7af22978c19d6e2954a337d26 (MD5) Previous issue date: 2007-05-16A depress?o ?
Pedrazza, Eduardo Luiz
core
The Enzymology of Cytosolic Pyrimidine 5'-Nucleotidases: Functional Analysis and Physiopathological Implications. [PDF]
, 2013 In mammals, cellular 5'-nucleotidase (5'-NT) activity (EC 3.1.3.5) encompasses a number of genetically and structurally distinct enzyme forms, either membrane-bound or soluble, mainly cytosolic, that are characterized by broad specificity towards ...
AMICI, Adolfo +2 more
core +1 more source