Results 91 to 100 of about 9,655 (264)

5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications [PDF]

, 2013
Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region ...
Dobolyi, Árpád, Juhász, Gábor, Kovács, Zsolt, Kékesi, Katalin A.   +3 more
core  

Determination of total potentially available nucleosides in bovine milk [PDF]

, 2010
Bovine colostrum and milk samples were collected from two herds over the course of the first month post-partum, pooled for each herd by stage of lactation and total potentially available nucleosides were determined.
Gill, Brendon D., Indyk, Harvey E., Manley-Harris, Merilyn   +2 more
core   +2 more sources

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug‐Metabolizing Enzymes

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against hepatitis C virus. In vitro studies assessing the inhibition or induction potential of bemnifosbuvir on the CYP450 and UGT1A1 enzymes demonstrated that bemnifosbuvir is a weak inducer and a reversible and time‐dependent inhibitor of
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Steven Good, Arantxa Horga, Nancy Agrawal, Janet Hammond   +10 more
wiley   +1 more source

Possible roles of CD73 (ecto-5′-nucleotidase) and clinical significance in metastasis human cancer [PDF]

, 2020
Marco Antonio Lacerda‐Abreu, José Roberto Meyer‐Fernandes   +1 more
openalex   +1 more source

Purine and pyrimidine nucleotide metabolism in Mollicutes

Genetics and Molecular Biology, 2007
Several mollicute genome projects are underway, offering unique opportunities to study genes and metabolic pathways on a genome-wide scale. Here, we have analyzed the conservation and diversity of purine and pyrimidine metabolism in mycoplasmas.
Cristiano Valim Bizarro, Desirée Cigaran Schuck   +1 more
doaj   +1 more source

Safety of beta‐nicotinamide mononucleotide (β‐NMN) pursuant the regulation (EU) 2015/2283 and the bioavailability of nicotinamide from this source in the context of Directive 2002/46/EC

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on beta‐nicotinamide mononucleotide (β‐NMN) as a novel food (NF) pursuant to Regulation (EU) 2015/2283, including an evaluation of the safety of its use in food supplements as a source of niacin ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Ursula Gundert‐Remy, Francesca Marcon, Harry J. McArdle, Monika Neuhäuser‐Berthold, Miguel Prieto Maradona, Alexandros Siskos, Matthew Wright, Elisa Beneventi, Annamaria Rossi, Maura Magani, Karen Ildico Hirsch‐Ernst   +28 more
wiley   +1 more source

CD73 is a major regulator of adenosinergic signalling in mouse brain.

PLoS ONE, 2013
CD73 (ecto-5'-nucleotidase) is a cell surface enzyme that regulates purinergic signalling by desphosphorylating extracellular AMP to adenosine. 5'-nucleotidases are known to be expressed in brain, but the expression of CD73 and its putative physiological
Natalia Kulesskaya, Vootele Võikar, Marjaana Peltola, Gennady G Yegutkin, Marko Salmi, Sirpa Jalkanen, Heikki Rauvala   +6 more
doaj   +1 more source

Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R [PDF]

, 2015
Adenosine is a widespread neuromodulator within the CNS and its extracellular level is increased during hypoxia or intense synaptic activity, modulating pre- and postsynaptic sites.
BERTOLLINI, Cristina, DI ANGELANTONIO, SILVIA, LIMATOLA, Cristina, PAGANI, FRANCESCA, PICCININ, Sonia, RAGOZZINO, Davide Antonio, ROSITO, MARIA, TRETTEL, Flavia   +7 more
core   +1 more source

Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man [PDF]

, 2005
Background/Aims: Degradation of adenine nucleotides to adenosine has been suggested to play a critical role in ischemic preconditioning (IPC). Thus, we questioned in patients undergoing partial hepatectomy whether (i) IPC will increase plasma purine ...
Chouker, A., Dugas, Martin, Heizmann, O., Martignoni, A., Messmer, K., Peter, K., Rau, H. G., Schauer, R. J., Thiel, M., Volk, A.   +9 more
core   +1 more source

ENTPDase inhibitors: therapeutic potential in infectious, inflammatory, and neuroinflammatory diseases [PDF]

Exploration of Neuroscience
Ectonucleoside triphosphate diphosphohydrolases (ENTPDases), members of the cluster of differentiation 39 (CD39) family, are key regulators of purinergic signaling through the hydrolysis of tri and diphosphate nucleotides.
Isadora Cunha Ribeiro, Amanda Laviola de Andrade, Vitória de Almeida Rodrigues, Markson Suarez Lacôrte Lima, Juliana Lopes Rangel Fietto   +4 more
doaj   +1 more source