Results 101 to 110 of about 3,609 (205)

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Receptor Activation by ATP Through Rapid and Localized Generation of Adenosine by Ecto-nucleotidases

Journal of Pharmacological Sciences, 2004
Extracellular ATP is now recognized as a neurotransmitter or neuromodilator in the nervous system, producing diverse physiological effects by activating multiple P2 receptors.
Isao Matsuoka, Satoko Ohkubo
doaj   +1 more source

Identificação das características cinéticas, expressão e localização das ecto-nucleotidases em cultura de astrócitos e linhagens de gliomas [PDF]

, 2003
Nucleotídeos extracelulares são envolvidos em diversos processos patofisiológicos no sistema nervoso central. Astrócitos são a maior fonte de nucleotídeos extracelulares da adenina no cérebro e também importantes alvos para as ações desses nucleotídeos ...
Marcia Rosangela Wink, Wink, Marcia Rosangela   +1 more
core   +1 more source

Plasma extracellular vesicle surface-located GAS6/PROS1 and CD39/CD73 attenuate inflammation

Cell Reports
Summary: Herein, we demonstrate that extracellular vesicles (EVs) present in healthy human plasma regulate macrophage activation by triggering MERTK-dependent signaling in a growth arrest-specific 6 (GAS6)- and protein S (PROS1)-dependent manner ...
Martina P. Fabiano, Alan M. Adamczyk, Olesia A. Gololobova, Ignacio G. Mazzitelli, María L. Leicaj, Tomás M. Grosso, Paula S. Pérez, Cora L. Alvarez, Julieta Schachter, Silvina Palmer, Florencia Sabbione, Fernando A. Erra Díaz, Analía S. Trevani, Manuel Varas-Godoy, Eugenio A. Carrera Silva, Kenneth W. Witwer, Matías Ostrowski   +16 more
doaj   +1 more source

5-Nucleotidase [PDF]

Biochemical Journal, 1938
J M, Gulland, E M, Jackson
openaire   +2 more sources

Intravascular ADP and soluble nucleotidases contribute to acute prothrombotic state during vigorous exercise in humans [PDF]

, 2007
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2007 The Physiological Society .Extracellular ATP and ADP trigger vasodilatatory and prothrombotic signalling ...
Mortensen, S P, Gonzalez-Alonso, J, Yegutkin, G G, Samburski, S S, González-Alonso J, Samburski SS, Jalkanen S, Yegutkin GG, Jalkanen, S, Mortensen SP   +9 more
core   +1 more source

Avaliação da participação das ecto-nucleotidases do Trypanosoma cruzi nos processos de infecção e virulência em modelo murino. [PDF]

, 2008
A Doença de Chagas é uma das doenças parasitárias com maior impacto social e econômico na América Latina, acometendo, ainda hoje, milhares de pessoas.
Pôssa, Marcela Auxiliadora Souza
core   +2 more sources

Structural Studies of Human 5'-Nucleotidases [PDF]

, 2008
5’-Nucleotidases (5’NTs) are catabolic enzymes of the nucleotide metabolism. They catalyze dephosphorylation of deoxyribo- and ribonucleoside monophosphates and constitute an important control point in the regulation of intracellular nucleotide pools for
Walldén, Karin
core  

Purinergic signalling: past, present and future [PDF]

, 2009
The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
G. Burnstock, Burnstock, G
core  

High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors [PDF]

One of the strategies used by tumors to evade immunosurveillance is the accumulation of extracellular adenosine, which has immunosupressive and tumor promoting effects.
Texidó, Laura, Ponce, Jordi, Vidal-Bel, August, Martín Satué, Mireia, Aliagas Marín, Elisabeth, Condom i Mundó, Enric   +5 more
core  

Pyrimidine 5′ Nucleotidase Deficiency [PDF]

British Journal of Haematology, 2003
Rees, David C., Duley, John A., Marinaki, Anthony M.   +2 more
openaire   +5 more sources