Results 81 to 90 of about 3,609 (205)

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage [PDF]

, 2019
ATP and adenosine are important signaling molecules involved in vascular remodeling, retinal function, and neurovascular coupling in the eye. Current knowledge on enzymatic pathways governing the duration and magnitude of ocular purinergic signaling is ...
Losenkova, Karolina, Korhonen, AM, Kaarniranta, K, Loukovaara, S, Zeiner, Julian, Lehti, K,, Kaarniranta, Kai, Jalkanen, Sirpa, Mueller, Christa E., Jalkanen, S, Lehti, Kaisa, Mueller, CE, Zuccarini, Mariachiara, Yegutkin, Gennady G., Korhonen, Ani M., Zeiner, J, Losenkova, K, Zuccarini, M, Loukovaara, Sirpa, Kauppinen, A, Kauppinen, Anu   +20 more
core   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto-nucleotidases [PDF]

, 1999
We investigated the expression and function of P2 receptors and ecto-nucleotidases on human monocyte derived dendritic cells (DC). In addition we analyzed the effect of extracellular ATP on the maturation of DC.
Bogdan, Cornelia, Cornelia Bogdan, Steinkasserer, Alexander, Petra Mühl-Zürbes, Berchtold, Susanne, Alexandra L.J. Ogilvie, Schuler, Gerold, Ogilvie, Alexandra L.J., Adaling Ogilvie, Gerold Schuler, Mühl-Zürbes, Petra, Ogilvie, Adaling, Alexander Steinkasserer, Susanne Berchtold   +13 more
core   +1 more source

Catabolism of Ap4A and Ap5A by rat brain synaptosomes

Brazilian Journal of Medical and Biological Research, 1998
Adenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) and adenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) are stored in and released from rat brain synaptic terminals.
T. Emanuelli, C.D. Bonan, J.J.F. Sarkis, A.M.O. Battastini   +3 more
doaj   +1 more source

Ectonucleotidases CD39 and CD73 expression levels are independent and inverse predictors of survival in muscle‐invasive bladder cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Bladder cancer is one of the leading causes of cancer‐related mortality worldwide. Long‐term survival is particularly poor in patients with muscle‐invasive bladder cancer (MIBC). Modulation of purinergic signaling through the ectonucleotidases CD39 and CD73 has emerged as a promising therapeutic strategy in cancer medicine.
Stephan Ledderose, Julia Schwenke, Lennert Eismann, Severin Rodler, Martina Rudelius, Carola Ledderose   +5 more
wiley   +1 more source

Testing knockdown of nucleotidases and the effect on e-Ado production during immune response in Drosophila melanogaster larvae [PDF]

, 2018
The aim of this thesis was to measure adenosine production from lymph glands in D. melanogaster larvae ex vivo and to assess the differences upon infection with parasitic wasps L. boulardi.
STEHRER, Thomas
core  

Neuronal NTPDase3 Mediates Extracellular ATP Degradation in Trigeminal Nociceptive Pathway.

PLoS ONE, 2016
ATP induces pain via activation of purinergic receptors in nociceptive sensory nerves. ATP signaling is terminated by ATP hydrolysis mediated by cell surface-localized ecto-nucleotidases.
Lihua Ma, Thu Trinh, Yanfang Ren, Robert T Dirksen, Xiuxin Liu   +4 more
doaj   +1 more source

Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT Extracellular vesicles (EVs), lipid bilayer nanoparticles released by virtually all cells, serve as essential messengers for intercellular communication. Due to their involvement in several pathophysiological processes, EVs have recently gained considerable attention as potentially diagnostic and prognostic biomarkers for various illnesses ...
Kwanele Xulu, Usri H. Ibrahim, Irene Mackraj, Carola Niesler   +3 more
wiley   +1 more source

A Novel Polyphosphate‐Degrading Enzyme Confers Growth on Exogenous Polyphosphate in the Archaeon Haloferax volcanii

Environmental Microbiology, Volume 28, Issue 7, July 2026.
A novel polyP‐degrading enzyme with an activity differing from those currently known was found in Haloferax volcanii, conferring the ability for this microbe to grow on extracellular polyP. These findings further our understanding of the potential ecological roles of polyP and how archaea metabolise this essential biopolymer.
Jack W. F. Nicholls, Vincent O'Flaherty, Timothy M. Lenton, John W. McGrath, Jason P. Chin   +4 more
wiley   +1 more source

0068 : Protective role of nucleotidases against the development of hypertension [PDF]

, 2015
Hypertension is characterized by a hypertrophic remodeling of big arteries, increased tone in smallest, endothelial dysfunction and accompanied by oxidative stress, inflammation and fibrosis.
Roy, Charlotte, Toutain, Bertrand, Henrion, Daniel, Guihot, Anne-Laure, Kauffenstein, Gilles, Sévigny, Jean   +5 more
core   +1 more source