Results 51 to 60 of about 2,769,148 (383)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Nucleotide imbalance decouples cell growth from cell proliferation

Nature Cell Biology, 2021
Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth and division. Nucleotide depletion can inhibit cell growth and proliferation, but how cells sense and respond to changes in the relative levels of individual ...
Frances F. Diehl, Teemu P. Miettinen, R. Elbashir, C. Nabel, Alicia M. Darnell, Brian T. Do, S. Manalis, C. Lewis, M. V. Vander Heiden   +8 more
semanticscholar   +1 more source

A Novel Single Nucleotide Polymorphism in Exon 4 of Insulin-Like Growth Factor-1 Associated with Production Traits in Bali Cattle [PDF]

, 2012
Insulin-like growth factor-1 (IGF-1) is one of the gene candidates that can be used in selection strategy by using DNA markers (marker assisted selection).
Arman, C. (C), Gurnadi, E. (E), Maskur, M. (Maskur), Muladno, M. (Muladno), Sumantri, C. (C)   +4 more
core  

Molecular and morphometric variation in European populations of the articulate brachiopod Terebeatulina retusa [PDF]

, 1993
Molecular and morphometric variation within and between population samples of the articulate brachiopod <i>Terebratulina</i> spp., collected in 1985-1987 from a Norwegian fjord, sea lochs and costal sites in western Scotland, the southern ...
A. C. Wilson, A. Logan, B. L. Cohen, B. Manly, C. A. Reeb, C. H. Brunton, C. S. Baker, E. S. Balakirev, E. S. Morse, F. J. Ayala, G. B. Curry, G. B. Curry, G. R. Webb, H. McCammon, H. T. Jacobs, I. I. Wirgin, J. C. Avise, J. C. Avise, J. C. Avise, J. C. Millr, J. D. Milliman, J. D. Peacock, J. E. Graves, J. P. A. Noble, J. W. Valentine, J. W. Valentine, L. Vawter, M. J. S. Rudwick, M. Nei, M. Nei, M. Nei, Marine Biological Association, U.K., N.-A. Morner, R. R. Sokal, T. Davidson, W. H. Dall   +35 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Error correction and diversity analysis of population mixtures determined by NGS [PDF]

, 2014
The impetus for this work was the need to analyse nucleotide diversity in a viral mix taken from honeybees. The paper has two findings. First, a method for correction of next generation sequencing error in the distribution of nucleotides at a site is ...
Burroughs, Nigel J., Evans, David J., Ryabov, Eugene V., Wood, Graham R.   +3 more
core   +3 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Revealing the complete mtDNA genome sequence of Cemani chicken () by using Nanopore sequencing analysis [PDF]

Animal Bioscience
Objective This study aimed to identify, discover and explore the characteristics of the mtDNA genomes of Cemani chicken (Gallus gallus). Methods This study used gDNA of Cemani chicken isolated from liver tissue.
Sutopo Sutopo, Dela Ayu Lestari, Asep Setiaji, Sri Rachma Aprilita Bugiwati, Muhammad Ihsan Andi Dagong, Nena Hilmia, Dani Garnida, Indrawati Yudha Asmara, Edy Kurnianto   +8 more
doaj   +1 more source

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

Science, 2019
Spotting off-targets from gene editing Unintended genomic modifications limit the potential therapeutic use of gene-editing tools. Available methods to find off-targets generally do not work in vivo or detect single-nucleotide changes.
Erwei Zuo, Yidi Sun, Wu Wei, Tanglong Yuan, Wenqin Ying, Hao Sun, Liyun Yuan, L. Steinmetz, Yixue Li, Hui Yang   +9 more
semanticscholar   +1 more source

A mutate-and-map protocol for inferring base pairs in structured RNA

, 2013
Chemical mapping is a widespread technique for structural analysis of nucleic acids in which a molecule's reactivity to different probes is quantified at single-nucleotide resolution and used to constrain structural modeling.
CS Chow, D Moazed, DH Mathews, EE Regulski, JB Lucks, JG Underwood, JP Staley, KA Wilkinson, M Kertesz, M Mandal, N Kulshina, NB Leontis, P Cordero, P Cordero, P Rocca-Serra, P Tijerina, PJ Lukavsky, R Rydzanicz, RC Spitale, RF Gesteland, S Mitra, S Washietl, S Yoon, SA Mortimer, SE Wells, SM Vasa, SW Brostoff, VD Sood, W Kladwang, W Kladwang, W Kladwang, W Kladwang, Y Rhee   +32 more
core   +1 more source