Epigenetic Regulation of Nucleotide Excision Repair [PDF]
Frontiers in Cell and Developmental Biology, 2022 Genomic DNA is constantly attacked by a plethora of DNA damaging agents both from endogenous and exogenous sources. Nucleotide excision repair (NER) is the most versatile repair pathway that recognizes and removes a wide range of bulky and/or helix ...
Wentao Li +4 more
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Nucleotide excision repair: a versatile and smart toolkit [PDF]
Acta Biochimica et Biophysica Sinica, 2022 Nucleotide excision repair (NER) is a major pathway to deal with bulky adducts induced by various environmental toxins in all cellular organisms. The two sub-pathways of NER, global genome repair (GGR) and transcription-coupled repair (TCR), differ in ...
Zhang Xiping, Yin Mengdie, Hu Jinchuan
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Resistance to Nucleotide Excision Repair of Bulky Guanine Adducts Opposite Abasic Sites in DNA Duplexes and Relationships between Structure and Function. [PDF]
PLoS ONE, 2015 The nucleotide excision repair of certain bulky DNA lesions is abrogated in some specific non-canonical DNA base sequence contexts, while the removal of the same lesions by the nucleotide excision repair mechanism is efficient in duplexes in which all ...
Zhi Liu +6 more
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The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair. [PDF]
PLoS ONE, 2012 The many proteins that function in the Fanconi anaemia (FA) monoubiquitylation pathway initiate replicative DNA crosslink repair. However, it is not clear whether individual FA genes participate in DNA repair pathways other than homologous recombination ...
Ian R Kelsall +4 more
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Nature Communications, 2022 Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.
Namrata Kumar +11 more
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Nucleotide excision repair genes shaping embryonic development [PDF]
Open Biology, 2019 Nucleotide excision repair (NER) is a highly conserved mechanism to remove helix-distorting DNA lesions. A major substrate for NER is DNA damage caused by environmental genotoxins, most notably ultraviolet radiation.
Sofia J. Araújo, Isao Kuraoka
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How chromatin is remodelled during DNA repair of UV-induced DNA damage in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2011 Global genome nucleotide excision repair removes DNA damage from transcriptionally silent regions of the genome. Relatively little is known about the molecular events that initiate and regulate this process in the context of chromatin.
Shirong Yu +3 more
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Triple negative breast cancers have a reduced expression of DNA repair genes. [PDF]
PLoS ONE, 2013 DNA repair is a key determinant in the cellular response to therapy and tumor repair status could play an important role in tailoring patient therapy. Our goal was to evaluate the mRNA of 13 genes involved in different DNA repair pathways (base excision,
Enilze Ribeiro +12 more
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Nature Communications, 2020 DNA damage sensors DDB2 and XPC are fundamental factors to initiate global genome nucleotide excision repair and protect DNA from mutagenesis. Here the authors reveal that ubiquitin and TFIIH-stimulated DDB2 dissociation promotes DNA damage handover to ...
Cristina Ribeiro-Silva +6 more
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The effect of essential oil of basil (Ocimum basilicum L.) on UV-induced mutagenesis in Escherichia coli and Saccharomyces cerevisiae [PDF]
Archives of Biological Sciences, 2008 The antimutagenic potential of essential oil (EO) of basil (Ocimum basilicum L.) and its major constituent linalool were studied with the E. coli K12 and S.cerevisiae D7 assays. In the E.
Stanojević Jasna +5 more
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