Results 11 to 20 of about 94,282 (203)

Prokaryotic Nucleotide Excision Repair [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Nucleotide excision repair (NER) has allowed bacteria to flourish in many different niches around the globe that inflict harsh environmental damage to their genetic material. NER is remarkable because of its diverse substrate repertoire, which differs greatly in chemical composition and structure.
Caroline, Kisker, Jochen, Kuper, Bennett, Van Houten   +2 more
openaire   +2 more sources

Molecular mechanism of nucleotide excision repair [PDF]

Genes & Development, 1999
From its very beginning, life has faced the fundamental problem that the form in which genetic information is stored is not chemically inert. DNA integrity is challenged by the damaging effect of numerous chemical and physical agents, compromizing its function.
Hoeijmakers, J.H.J. (Jan), Jaspers, N.G.J. (Nicolaas), Laat, W.L. (Wouter) de   +2 more
core   +6 more sources

The effect of essential oil of basil (Ocimum basilicum L.) on UV-induced mutagenesis in Escherichia coli and Saccharomyces cerevisiae [PDF]

Archives of Biological Sciences, 2008
The antimutagenic potential of essential oil (EO) of basil (Ocimum basilicum L.) and its major constituent linalool were studied with the E. coli K12 and S.cerevisiae D7 assays. In the E.
Stanojević Jasna, Berić Tanja, Opačić Biljana, Vuković-Gačić Branka, Simić Draga, Knežević-Vukčević Jelena   +5 more
doaj   +1 more source

TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair. [PDF]

, 2016
E-cadherin is a cell adhesion molecule best known for its function in suppressing tumor progression and metastasis. Here we show that E-cadherin promotes nucleotide excision repair through positively regulating the expression of xeroderma pigmentosum ...
Barcellos-Hoff, MH, He, YY, Qiang, L, Shah, P   +3 more
core   +1 more source

XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair

Nature Communications, 2022
Cells employ global genome nucleotide excision repair to repair a broad spectrum of genomic DNA lesions. Here, the authors reveal how chromatin is primed for repair, providing insight into mechanisms of chromatin plasticity during DNA repair.
Charlotte Blessing, Katja Apelt, Diana van den Heuvel, Claudia Gonzalez-Leal, Magdalena B. Rother, Melanie van der Woude, Román González-Prieto, Adi Yifrach, Avital Parnas, Rashmi G. Shah, Tia Tyrsett Kuo, Daphne E. C. Boer, Jin Cai, Angela Kragten, Hyun-Suk Kim, Orlando D. Schärer, Alfred C. O. Vertegaal, Girish M. Shah, Sheera Adar, Hannes Lans, Haico van Attikum, Andreas G. Ladurner, Martijn S. Luijsterburg   +22 more
doaj   +1 more source

Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells [PDF]

, 2010
Nucleotide excision repair (NER) is the most versatile DNA repair system that deals with the major UV photoproducts in DNA, as well as many other DNA adducts.
Cloney, Ross, Fousteri, Maria I, Japers, Nicolaas G, Lehmann, Alan R, Limsirichaikul, Siripan, Miki, Yoshio, Mullenders., Leon H F, Nakazawa, Yuka, Niimi, Atsuko, Ogi, Tomoo, Overmeer, René M, Takenaka, Katsuya, Volker, Marcel, Yamashita, Shunichi   +13 more
core   +3 more sources

SnapShot: Nucleotide Excision Repair

Cell, 2010
Nucleotide excision repair (NER) was discovered in both prokaryotes and eukaryotes in the 1960s (Friedberg et al., 2005). The process corrects a wide spectrum of damage to DNA bases that results in distortions in the native conformation of DNA, including damage induced by ultraviolet (UV) light and by a plethora of chemicals. NER comprises two distinct
Guo, Caixia, Tang, Tie-Shan, Friedberg, Errol C.   +2 more
openaire   +2 more sources

UV-Induced RPA1 Acetylation Promotes Nucleotide Excision Repair

Cell Reports, 2017
Replication protein A (RPA) is a multifunctional, single-stranded DNA-binding protein complex and plays a critical role in DNA replication and damage response.
Hanqing He, Jiajia Wang, Ting Liu
doaj   +1 more source

Dataset for the NMR structure of the intrinsically disordered acidic region of XPC bound to the PH domain of TFIIH p62

Data in Brief, 2016
The global genome nucleotide excision repair factor XPC firstly detects DNA lesions and then recruits a ten-subunit complex TFIIH through binding to the subunit p62 to unwind the damaged DNA for excision repair.
Masahiko Okuda, Yoshifumi Nishimura
doaj   +1 more source

Effects of replication domains on genome-wide UV-induced DNA damage and repair.

PLoS Genetics, 2022
Nucleotide excision repair is the primary repair mechanism that removes UV-induced DNA lesions in placentals. Unrepaired UV-induced lesions could result in mutations during DNA replication. Although the mutagenesis of pyrimidine dimers is reasonably well
Yanchao Huang, Cem Azgari, Mengdie Yin, Yi-Ying Chiou, Laura A Lindsey-Boltz, Aziz Sancar, Jinchuan Hu, Ogun Adebali   +7 more
doaj   +1 more source