Results 11 to 20 of about 48,126 (189)

UV-Induced RPA1 Acetylation Promotes Nucleotide Excision Repair

Cell Reports, 2017
Replication protein A (RPA) is a multifunctional, single-stranded DNA-binding protein complex and plays a critical role in DNA replication and damage response.
Hanqing He, Jiajia Wang, Ting Liu
doaj   +1 more source

XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair

Nature Communications, 2022
Cells employ global genome nucleotide excision repair to repair a broad spectrum of genomic DNA lesions. Here, the authors reveal how chromatin is primed for repair, providing insight into mechanisms of chromatin plasticity during DNA repair.
Charlotte Blessing, Katja Apelt, Diana van den Heuvel, Claudia Gonzalez-Leal, Magdalena B. Rother, Melanie van der Woude, Román González-Prieto, Adi Yifrach, Avital Parnas, Rashmi G. Shah, Tia Tyrsett Kuo, Daphne E. C. Boer, Jin Cai, Angela Kragten, Hyun-Suk Kim, Orlando D. Schärer, Alfred C. O. Vertegaal, Girish M. Shah, Sheera Adar, Hannes Lans, Haico van Attikum, Andreas G. Ladurner, Martijn S. Luijsterburg   +22 more
doaj   +1 more source

Effects of replication domains on genome-wide UV-induced DNA damage and repair.

PLoS Genetics, 2022
Nucleotide excision repair is the primary repair mechanism that removes UV-induced DNA lesions in placentals. Unrepaired UV-induced lesions could result in mutations during DNA replication. Although the mutagenesis of pyrimidine dimers is reasonably well
Yanchao Huang, Cem Azgari, Mengdie Yin, Yi-Ying Chiou, Laura A Lindsey-Boltz, Aziz Sancar, Jinchuan Hu, Ogun Adebali   +7 more
doaj   +1 more source

Modeling the thermal evolution of enzyme-created bubbles in DNA [PDF]

Interface, 2(2):89-95, 2005, 2004
The formation of bubbles in nucleic acids (NAs) are fundamental in many biological processes such as DNA replication, recombination, telomeres formation, nucleotide excision repair, as well as RNA transcription and splicing. These precesses are carried out by assembled complexes with enzymes that separate selected regions of NAs.
arxiv   +1 more source

First-passage problems in DNA replication: effects of template tension on stepping and exonuclease activities of a DNA polymerase motor [PDF]

Journal of Physics: Condensed Matter, vol.25, 374105 (2013), 2013
A DNA polymerase (DNAP) replicates a template DNA strand. It also exploits the template as the track for its own motor-like mechanical movement. In the polymerase mode it elongates the nascent DNA by one nucleotide in each step. But, whenever it commits an error by misincorporating an incorrect nucleotide, it can switch to an exonuclease mode.
arxiv   +1 more source

Transcription coupled repair and biased insertion of human retrotransposon L1 in transcribed genes

Mobile DNA, 2017
Background L1 retrotransposons inserted within genes in the human genome show a strong bias against sense orientation with respect to the gene. One suggested explanation for this observation was the possibility that L1 inserted randomly, but that there ...
Geraldine Servant, Vincent A. Streva, Prescott L. Deininger   +2 more
doaj   +1 more source

Regulation of nucleotide excision repair by nuclear lamin b1. [PDF]

PLoS ONE, 2013
The nuclear lamins play important roles in the structural organization and function of the metazoan cell nucleus. Recent studies on B-type lamins identified a requirement for lamin B1 (LB1) in the regulation of cell proliferation in normal diploid cells.
Veronika Butin-Israeli, Stephen A Adam, Robert D Goldman   +2 more
doaj   +1 more source

Charge transport-mediated recruitment of DNA repair enzymes [PDF]

Journal of Chemical Physics, 129, 235101, (2008), 2008
Damaged or mismatched bases in DNA can be repaired by Base Excision Repair (BER) enzymes that replace the defective base. Although the detailed molecular structures of many BER enzymes are known, how they colocalize to lesions remains unclear. One hypothesis involves charge transport (CT) along DNA [Yavin, {\it et al.}, PNAS, {\bf 102}, 3546, (2005 ...
arxiv   +1 more source

Global-genome Nucleotide Excision Repair Controlled by Ubiquitin/Sumo Modifiers

Frontiers in Genetics, 2016
Global-genome nucleotide excision repair (GG-NER) prevents genome instability by excising a wide range of structurally unrelated DNA base adducts and crosslinks induced by chemical carcinogens, ultraviolet (UV) radiation or intracellular metabolic by ...
Peter eRuethemann, Chiara eBalbo Pogliano, Hanspeter eNaegeli   +2 more
doaj   +1 more source

Accelerated search kinetics mediated by redox reactions of DNA repair enzymes [PDF]

Biophysical Journal, volume 96, pp 3949-3958, (2009), 2009
A Charge Transport (CT) mechanism has been proposed in several papers (e.g., Yavin, et al. PNAS, v102 3546 (2005)) to explain the localization of Base Excision Repair (BER) enzymes to lesions on DNA. The CT mechanism relies on redox reactions of iron-sulfur cofactors that modify the enzyme's binding affinity.
arxiv   +1 more source