Results 11 to 20 of about 82,343 (351)
Definitions, 2020 European Bioinformatics Institute, New York University Langone Medical Center, Ontario Institute for Cancer Research, Oregon Health and Science University.
W. Mcgregor
semanticscholar +3 more sources
Nucleotide excision repair in eukaryotes. [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Nucleotide excision repair (NER) is the main pathway used by mammals to remove bulky DNA lesions such as those formed by UV light, environmental mutagens, and some cancer chemotherapeutic adducts from DNA.
O. Schärer
semanticscholar +5 more sources
Prokaryotic nucleotide excision repair. [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Nucleotide excision repair (NER) has allowed bacteria to flourish in many different niches around the globe that inflict harsh environmental damage to their genetic material.
C. Kisker, J. Kuper, B. Van Houten
semanticscholar +3 more sources
Molecular mechanism of nucleotide excision repair. [PDF]
Genes & Development, 1999 From its very beginning, life has faced the fundamental problem that the form in which genetic information is stored is not chemically inert. DNA integrity is challenged by the damaging effect of numerous chemical and physical agents, compromizing its ...
W. L. D. Laat +2 more
semanticscholar +4 more sources
Nucleotide excision repair in humans. [PDF]
DNA Repair, 2015 The demonstration of DNA damage excision and repair replication by Setlow, Howard-Flanders, Hanawalt and their colleagues in the early 1960s, constituted the discovery of the ubiquitous pathway of nucleotide excision repair (NER). The serial steps in NER are similar in organisms from unicellular bacteria to complex mammals and plants, and involve ...
G. Spivak
semanticscholar +4 more sources
Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes
Cellular and Molecular Life Sciences, 2021 Global genome nucleotide excision repair (GG-NER) eliminates a broad spectrum of DNA lesions from genomic DNA. Genomic DNA is tightly wrapped around histones creating a barrier for DNA repair proteins to access DNA lesions buried in nucleosomal DNA.
K. Apelt +3 more
semanticscholar +1 more source
Nucleotide excision repair genes shaping embryonic development [PDF]
Open Biology, 2019 Nucleotide excision repair (NER) is a highly conserved mechanism to remove helix-distorting DNA lesions. A major substrate for NER is DNA damage caused by environmental genotoxins, most notably ultraviolet radiation.
Sofia J. Araújo, Isao Kuraoka
doaj +1 more source
Nucleotide Excision Repair (NER) [PDF]
Springer Reference Medizin, 2019 J. Arnemann
semanticscholar +3 more sources
The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage
Nucleic Acids Research, 2020 The six major mammalian DNA repair pathways were discovered as independent processes, each dedicated to remove specific types of lesions, but the past two decades have brought into focus the significant interplay between these pathways.
Namrata Kumar +2 more
semanticscholar +1 more source
Triple negative breast cancers have a reduced expression of DNA repair genes. [PDF]
PLoS ONE, 2013 DNA repair is a key determinant in the cellular response to therapy and tumor repair status could play an important role in tailoring patient therapy. Our goal was to evaluate the mRNA of 13 genes involved in different DNA repair pathways (base excision,
Enilze Ribeiro +12 more
doaj +1 more source