Results 21 to 30 of about 48,126 (189)

Base Sequence Context Effects on Nucleotide Excision Repair

Journal of Nucleic Acids, 2010
Nucleotide excision repair (NER) plays a critical role in maintaining the integrity of the genome when damaged by bulky DNA lesions, since inefficient repair can cause mutations and human diseases notably cancer. The structural properties of DNA lesions
Yuqin Cai, Dinshaw J. Patel, Suse Broyde, Nicholas E. Geacintov   +3 more
doaj   +1 more source

PCAF/GCN5-Mediated Acetylation of RPA1 Promotes Nucleotide Excision Repair

Cell Reports, 2017
The RPA complex can integrate multiple stress signals into diverse responses by activating distinct DNA repair pathways. However, it remains unclear how RPA1 elects to activate a specific repair pathway during different types of DNA damage.
Meimei Zhao, Rui Geng, Xiang Guo, Ruoshi Yuan, Xiao Zhou, Yanyan Zhong, Yanfei Huo, Mei Zhou, Qinjian Shen, Yinglu Li, Weiguo Zhu, Jiadong Wang   +11 more
doaj   +1 more source

Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice

npj Aging and Mechanisms of Disease, 2020
Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves
Zhonghe Ke, Denis Firsanov, Brianna Spencer, Andrei Seluanov, Vera Gorbunova   +4 more
doaj   +1 more source

DNA Repair Repertoire of the Enigmatic Hydra

Frontiers in Genetics, 2021
Since its discovery by Abraham Trembley in 1744, hydra has been a popular research organism. Features like spectacular regeneration capacity, peculiar tissue dynamics, continuous pattern formation, unique evolutionary position, and an apparent lack of ...
Apurva Barve, Apurva Barve, Alisha A. Galande, Saroj S. Ghaskadbi, Surendra Ghaskadbi   +4 more
doaj   +1 more source

Role of Base Excision Repair Pathway in the Processing of Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs

Frontiers in Cell and Developmental Biology, 2021
Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB).
Yeldar Baiken, Yeldar Baiken, Yeldar Baiken, Damira Kanayeva, Sabira Taipakova, Regina Groisman, Alexander A. Ishchenko, Dinara Begimbetova, Bakhyt Matkarimov, Murat Saparbaev, Murat Saparbaev   +10 more
doaj   +1 more source

DSBplot: Indels in DNA Double-strand Break Repair Experiments [PDF]

arXiv, 2023
Double-strand breaks (DSBs) in DNA are naturally occurring destructive events in all organisms that may lead to genome instability. Cells employ various repair methods known as non-homologous end joining (NHEJ), microhomology mediated end joining (MMEJ), and homology-directed recombination (HDR).
arxiv  

The interplay of mutations and electronic properties in disease-related genes [PDF]

Scientific Reports 2, 272-9 (2012), 2011
Electronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycosylases and the regulation of tumor-suppressor genes such as p53 by detection of oxidative damage.
arxiv   +1 more source

Interactome analysis and docking sites prediction of (AtCHR8, AtCUL4 and AtERCC1/UVR7) proteins in Arabidopsis Thaliana

Heritage and Sustainable Development, 2020
The UV irradiation is a major DNA damaging factor in plants. Arabidopsis thaliana uses various repair pathways for these kinds of DNA lesions. One of them is the nucleotide excision repair pathway.
Mohamed Ragab Abdel Gawwad, Ali Taha Ozdemir   +1 more
doaj   +1 more source

In vitro reconstitution of an efficient nucleotide excision repair system using mesophilic enzymes from Deinococcus radiodurans

Communications Biology, 2022
Reconstitution of D radiodurans nucleotide excision repair provides insights into the kinetics of repair on different DNA substrates and determines the order and precise sites of incisions on the 5’ and 3’ sides of the lesion.
Anna Seck, Salvatore De Bonis, Christine Saint-Pierre, Didier Gasparutto, Jean-Luc Ravanat, Joanna Timmins   +5 more
doaj   +1 more source

Genome-wide excision repair in Arabidopsis is coupled to transcription and reflects circadian gene expression patterns

Nature Communications, 2018
Plants use nucleotide excision repair to maintain genome integrity in response to damage caused by stresses such as UV radiation. Here Oztas et al. use genome-wide profiling to show that excision repair in Arabidopsis is strongly coupled to transcription
Onur Oztas, Christopher P. Selby, Aziz Sancar, Ogun Adebali   +3 more
doaj   +1 more source