Results 21 to 30 of about 82,343 (351)
Role of Nucleotide Excision Repair in Cisplatin Resistance
International Journal of Molecular Sciences, 2020 Cisplatin is a chemotherapeutic drug used for the treatment of a number of cancers. The efficacy of cisplatin relies on its binding to DNA and the induction of cytotoxic DNA damage to kill cancer cells.
M. Duan, J. Ulibarri, K. Liu, Peng Mao
semanticscholar +1 more source
PLoS ONE, 2012 The many proteins that function in the Fanconi anaemia (FA) monoubiquitylation pathway initiate replicative DNA crosslink repair. However, it is not clear whether individual FA genes participate in DNA repair pathways other than homologous recombination ...
Ian R Kelsall +4 more
doaj +1 more source
The effect of essential oil of basil (Ocimum basilicum L.) on UV-induced mutagenesis in Escherichia coli and Saccharomyces cerevisiae [PDF]
Archives of Biological Sciences, 2008 The antimutagenic potential of essential oil (EO) of basil (Ocimum basilicum L.) and its major constituent linalool were studied with the E. coli K12 and S.cerevisiae D7 assays. In the E.
Stanojević Jasna +5 more
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XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
Nature Communications, 2022 Cells employ global genome nucleotide excision repair to repair a broad spectrum of genomic DNA lesions. Here, the authors reveal how chromatin is primed for repair, providing insight into mechanisms of chromatin plasticity during DNA repair.
Charlotte Blessing +22 more
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SnapShot: Nucleotide Excision Repair
Cell, 2010 Nucleotide excision repair (NER) was discovered in both prokaryotes and eukaryotes in the 1960s (Friedberg et al., 2005). The process corrects a wide spectrum of damage to DNA bases that results in distortions in the native conformation of DNA, including damage induced by ultraviolet (UV) light and by a plethora of chemicals. NER comprises two distinct
Tie-Shan Tang +2 more
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UV-Induced RPA1 Acetylation Promotes Nucleotide Excision Repair
Cell Reports, 2017 Replication protein A (RPA) is a multifunctional, single-stranded DNA-binding protein complex and plays a critical role in DNA replication and damage response.
Hanqing He, Jiajia Wang, Ting Liu
doaj +1 more source
Base Flipping in Nucleotide Excision Repair [PDF]
Journal of Biological Chemistry, 2006 UvrB, the ultimate damage-binding protein in bacterial nucleotide excision repair is capable of binding a vast array of structurally unrelated lesions. A beta-hairpin structure in the protein plays an important role in damage-specific binding. In this paper we have monitored DNA conformational alterations in the UvrB-DNA complex, using the fluorescent ...
Malta, E., Moolenaar, G.F., Goosen, N.
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Effects of replication domains on genome-wide UV-induced DNA damage and repair.
PLoS Genetics, 2022 Nucleotide excision repair is the primary repair mechanism that removes UV-induced DNA lesions in placentals. Unrepaired UV-induced lesions could result in mutations during DNA replication. Although the mutagenesis of pyrimidine dimers is reasonably well
Yanchao Huang +7 more
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Nucleotide excision repair and human syndromes [PDF]
Carcinogenesis, 2000 DNA damage is implicated in cancer and aging, and several DNA repair mechanisms exist that safeguard the genome from these deleterious consequences. Nucleotide excision repair (NER) removes a wide diversity of lesions, the main of which include UV-induced lesions, bulky chemical adducts and some forms of oxidative damage.
Jan de Boer, Jan H.J. Hoeijmakers
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How chromatin is remodelled during DNA repair of UV-induced DNA damage in Saccharomyces cerevisiae.
PLoS Genetics, 2011 Global genome nucleotide excision repair removes DNA damage from transcriptionally silent regions of the genome. Relatively little is known about the molecular events that initiate and regulate this process in the context of chromatin.
Shirong Yu +3 more
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