Results 31 to 40 of about 98,783 (332)
17β‐Oestradiol attenuates nucleotide excision repair [PDF]
FEBS Letters, 2003 Epidemiological studies strongly suggest associations between chronic exposure to endogenous oestrogens and the development of breast and gynaecological tumours. Two mechanisms by which 17β‐oestradiol (E2) may enhance tumorigenesis are: (i) enhancement of cell proliferation and (ii) the production of reactive, genotoxic metabolites.
Evans, MD +5 more
openaire +3 more sources
Cell Reports, 2020 Summary: ADP-ribosylation of proteins is crucial for fundamental cellular processes. Despite increasing examples of DNA ADP-ribosylation, the impact of this modification on DNA metabolism and cell physiology is unknown. Here, we show that the DarTG toxin-
Emeline Lawarée +5 more
doaj +1 more source
Regulation of nucleotide excision repair by nuclear lamin b1. [PDF]
PLoS ONE, 2013 The nuclear lamins play important roles in the structural organization and function of the metazoan cell nucleus. Recent studies on B-type lamins identified a requirement for lamin B1 (LB1) in the regulation of cell proliferation in normal diploid cells.
Veronika Butin-Israeli +2 more
doaj +1 more source
Transcription coupled repair and biased insertion of human retrotransposon L1 in transcribed genes
Mobile DNA, 2017 Background L1 retrotransposons inserted within genes in the human genome show a strong bias against sense orientation with respect to the gene. One suggested explanation for this observation was the possibility that L1 inserted randomly, but that there ...
Geraldine Servant +2 more
doaj +1 more source
C. elegans survival assays to discern global and transcription-coupled nucleotide excision repair
STAR Protocols, 2021 Summary: Global genome nucleotide excision repair (GG-NER) and transcription-coupled nucleotide excision repair (TC-NER) protect cells against a variety of helix-distorting DNA lesions. In C. elegans, GG-NER primarily acts in proliferative germ cells and
Melanie van der Woude, Hannes Lans
doaj +1 more source
The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster. [PDF]
, 2016 Despite decades of work, our understanding of the distribution of fitness effects of segregating genetic variants in natural populations remains largely incomplete. One form of selection that can maintain genetic variation is spatially varying selection,
Begun, David J +3 more
core +4 more sources
Global-genome Nucleotide Excision Repair Controlled by Ubiquitin/Sumo Modifiers
Frontiers in Genetics, 2016 Global-genome nucleotide excision repair (GG-NER) prevents genome instability by excising a wide range of structurally unrelated DNA base adducts and crosslinks induced by chemical carcinogens, ultraviolet (UV) radiation or intracellular metabolic by ...
Peter eRuethemann +2 more
doaj +1 more source
Nucleotide excision repair in humans [PDF]
DNA Repair, 2015 The demonstration of DNA damage excision and repair replication by Setlow, Howard-Flanders, Hanawalt and their colleagues in the early 1960s, constituted the discovery of the ubiquitous pathway of nucleotide excision repair (NER). The serial steps in NER are similar in organisms from unicellular bacteria to complex mammals and plants, and involve ...
openaire +2 more sources
Base Sequence Context Effects on Nucleotide Excision Repair
Journal of Nucleic Acids, 2010 Nucleotide excision repair (NER) plays a critical role in maintaining the integrity of the genome when damaged by bulky DNA lesions, since inefficient repair can cause mutations and human diseases notably cancer. The structural properties of DNA lesions
Yuqin Cai +3 more
doaj +1 more source