Results 31 to 40 of about 48,126 (189)
Emerging Roles of Post-Translational Modifications in Nucleotide Excision Repair
Cells, 2020 Nucleotide excision repair (NER) is a versatile DNA repair pathway which can be activated in response to a broad spectrum of UV-induced DNA damage, such as bulky adducts, including cyclobutane-pyrimidine dimers (CPDs) and 6–4 photoproducts (6–4PPs ...
Barbara N. Borsos +2 more
doaj +1 more source
Chemical Biology of Mammalian DNA Repair
CHIMIA, 2001 Damage to the heterocyclic bases of DNA in the genome is mainly corrected by the base excision repair (BER) or nucleotide excision repair (NER) pathways.
Orlando D. Schärer
doaj +2 more sources
Exploiting DNA repair defects in triple negative breast cancer to improve cell killing
Therapeutic Advances in Medical Oncology, 2020 Background: The lack of molecular targets for triple negative breast cancer (TNBC) has limited treatment options and reduced survivorship. Identifying new molecular targets may help improve patient survival and decrease recurrence and metastasis.
Kevin J. Lee +5 more
doaj +1 more source
A simple model describing evolution of genomic GC content with random perturbations in asexually reproducing organisms [PDF]
arXiv, 2022 A model is presented relating the evolution of genomic GC content over time to AT$\rightarrow$GC and GC$\rightarrow$AT mutation rates. By employing It\^o calculus it is shown that if mutation rates in asexually reproducing organisms are subject to random perturbations that can vary over time several implications follow.
arxiv
Zuo1 supports G4 structure formation and directs repair toward nucleotide excision repair
Nature Communications, 2020 G4 structure-interacting proteins have been linked to DNA repair processes. Here the authors reveal that in yeast, Zuo1 associates with G4 structures and plays a role in repair pathway choice by promoting nucleotide excision repair and ultimately ...
Alessio De Magis +6 more
doaj +1 more source
UV Protection in the Cornea: Failure and Rescue
Biology, 2022 Ultraviolet (UV) irradiation induces DNA lesions in all directly exposed tissues. In the human body, two tissues are chronically exposed to UV: the skin and the cornea.
Thomas Volatier +3 more
doaj +1 more source
The maintenance of sex in bacteria is ensured by its potential to reload genes [PDF]
Genetics 174, 2173-2180 (2006)., 2006 Why sex is maintained in nature is a fundamental question in biology. Natural genetic transformation (NGT) is a sexual process by which bacteria actively take up exogenous DNA and use it to replace homologous chromosomal sequences. As it has been demonstrated, the role of NGT in repairing deleterious mutations under constant selection is insufficient ...
arxiv +1 more source
The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis
Antioxidants, 2022 The mortality rate of idiopathic pulmonary fibrosis (IPF) increases yearly due to ineffective treatment. Given that the lung is exposed to the external environment, it is likely that oxidative stress, especially the stimulation of DNA, would be of ...
Jiahui Zhu +10 more
doaj +1 more source
Nonlinear waves in double-stranded DNA [PDF]
arXiv, 2004 We propose a nonlinear model derived from first principles, to describe bubble dynamics of DNA. Our model equations include a term derived from the dissipative effect of intermolecular vibrational modes. Such modes are excited by the propagating bubble, and we term it "curvature dissipation".
arxiv
Journal of Nucleic Acids, 2012 UvrD is a DNA helicase that participates in nucleotide excision repair and several replication-associated processes, including methyl-directed mismatch repair and recombination.
Kelley N. Newton +2 more
doaj +1 more source