Results 31 to 40 of about 82,343 (351)
Mechanism and regulation of DNA damage recognition in nucleotide excision repair
Genes and Environment, 2019 Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the genome. In mammalian global genomic NER, the XPC protein complex initiates the repair reaction by recognizing sites of ...
M. Kusakabe +9 more
semanticscholar +1 more source
Nucleotide Excision Repair inCaenorhabditis elegans [PDF]
Molecular Biology International, 2011 Nucleotide excision repair (NER) plays an essential role in many organisms across life domains to preserve and faithfully transmit DNA to the next generation. In humans, NER is essential to prevent DNA damage-induced mutation accumulation and cell death leading to cancer and aging.
Hannes Lans, Wim Vermeulen
openaire +3 more sources
Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer
Genome Research, 2019 Nucleotide excision repair (NER) is one of the main DNA repair pathways that protect cells against genomic damage. Disruption of this pathway can contribute to the development of cancer and accelerate aging.
M. Jager +13 more
semanticscholar +1 more source
Nucleic Acids Research, 2018 Sensitivity and resistance of cells to platinum drug chemotherapy are to a large extent determined by activity of the DNA damage response (DDR). Combining chemotherapy with inhibition of specific DDR pathways could therefore improve treatment efficacy ...
J. Slyskova +6 more
semanticscholar +1 more source
Regulation of nucleotide excision repair by nuclear lamin b1. [PDF]
PLoS ONE, 2013 The nuclear lamins play important roles in the structural organization and function of the metazoan cell nucleus. Recent studies on B-type lamins identified a requirement for lamin B1 (LB1) in the regulation of cell proliferation in normal diploid cells.
Veronika Butin-Israeli +2 more
doaj +1 more source
Nucleotide excision repair of abasic DNA lesions
Nucleic Acids Research, 2019 Apurinic/apyrimidinic (AP) sites are a class of highly mutagenic and toxic DNA lesions arising in the genome from a number of exogenous and endogenous sources. Repair of AP lesions takes place predominantly by the base excision pathway (BER).
N. Kitsera +4 more
semanticscholar +1 more source
Transcription coupled repair and biased insertion of human retrotransposon L1 in transcribed genes
Mobile DNA, 2017 Background L1 retrotransposons inserted within genes in the human genome show a strong bias against sense orientation with respect to the gene. One suggested explanation for this observation was the possibility that L1 inserted randomly, but that there ...
Geraldine Servant +2 more
doaj +1 more source
Global-genome Nucleotide Excision Repair Controlled by Ubiquitin/Sumo Modifiers
Frontiers in Genetics, 2016 Global-genome nucleotide excision repair (GG-NER) prevents genome instability by excising a wide range of structurally unrelated DNA base adducts and crosslinks induced by chemical carcinogens, ultraviolet (UV) radiation or intracellular metabolic by ...
Peter eRuethemann +2 more
doaj +1 more source
DNA Repair Repertoire of the Enigmatic Hydra
Frontiers in Genetics, 2021 Since its discovery by Abraham Trembley in 1744, hydra has been a popular research organism. Features like spectacular regeneration capacity, peculiar tissue dynamics, continuous pattern formation, unique evolutionary position, and an apparent lack of ...
Apurva Barve +4 more
doaj +1 more source
Nucleotide Excision Repair and TranscriptionâAssociated Genome Instability
Bioessays, 2019 Transcription is a potential threat to genome integrity, and transcriptionâassociated DNA damage must be repaired for proper messenger RNA (mRNA) synthesis and for cells to transmit their genome intact into progeny.
Zivkos Apostolou +3 more
semanticscholar +1 more source