Results 41 to 50 of about 48,126 (189)
arXiv, 2015 Fine-tuned regulation of the cellular nucleotide pools is indispensable for faithful replication of DNA. The genetic information is also safeguarded by DNA damage recognition and repair processes. Uracil is one of the most frequently occurring erroneous base in DNA; it can arise from cytosine deamination or thymine-replacing incorporation.
arxiv
Data in Brief, 2016 The global genome nucleotide excision repair factor XPC firstly detects DNA lesions and then recruits a ten-subunit complex TFIIH through binding to the subunit p62 to unwind the damaged DNA for excision repair.
Masahiko Okuda, Yoshifumi Nishimura
doaj
Journal of Nucleic Acids, 2010 DNA is subjected to many endogenous and exogenous damages. All organisms have developed a complex network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision ...
Rihito Morita +9 more
doaj +1 more source
Automated Image Processing for the Analysis of DNA Repair Dynamics [PDF]
arXiv, 2011 The efficient repair of cellular DNA is essential for the maintenance and inheritance of genomic information. In order to cope with the high frequency of spontaneous and induced DNA damage, a multitude of repair mechanisms have evolved. These are enabled by a wide range of protein factors specifically recognizing different types of lesions and finally ...
arxiv
A Binary Representation of the Genetic Code [PDF]
, 2016 This article introduces a novel binary representation of the canonical genetic code based on both the structural similarities of the nucleotides, as well as the physicochemical properties of the encoded amino acids. Each of the four mRNA bases is assigned a unique 2-bit identifier, so that the 64 triplet codons are each indexed by a 6-bit label.
arxiv +1 more source
Modelling the Structure of a Protein Domain (N-terminal of XPB) Linked with Protein Synthesis, DNA Damage Repair, Rare Diseases, Cancer Therapeutics, and Tuberculosis [PDF]
arXiv, 2016 In this work, we develop first near-complete 3D models for NTD-hXPB - the N-terminal protein domain of the human transcription factor XPB. The results are very significant as NTD-hXPB plays a critical role in the synthesis of proteins (specifically transcription) and DNA damage repair (specifically nucleotide excision repair).
arxiv
Spectral Excision and Descent for Almost Perfect Complexes [PDF]
arXiv, 2022 We show that almost perfect complexes of commutative ring spectra satisfy excision and $v$-descent. These results generalize Milnor excision for perfect complexes of ordinary commutative rings and $v$-descent for almost perfect complexes of locally noetherian derived stacks by Halpern-Leistner and Preygel, respectively.
arxiv
Cells, 2020 LAP2-Emerin-MAN1 (LEM) domain-containing proteins represent an abundant group of inner nuclear membrane proteins involved in diverse nuclear functions, but their functional redundancies remain unclear.
Bernhard Moser +4 more
doaj +1 more source
Mismatch Repair Error Implies Chargaff's Second Parity Rule [PDF]
arXiv, 2007 Chargaff's second parity rule holds empirically for most types of DNA that along single strands of DNA the base contents are equal for complimentary bases, A = T, G = C. A Markov chain model is constructed to track the evolution of any single base position along single strands of genomes whose organisms are equipped with replication mismatch repair ...
arxiv
Comparative analysis of the nucleotide composition biases in exons and introns of human genes [PDF]
arXiv, 2010 The nucleotide composition of human genes with a special emphasis on transcription-related strand asymmetries is analyzed. Such asymmetries may be associated with different mutational rates in two principal factors. The first one is transcription-coupled repair and the second one is the selective pressure related to optimization of the translation ...
arxiv