Results 41 to 50 of about 82,343 (351)

Nucleotide Excision Repair and Cancer [PDF]

, 2011
Cancer ranks as one of the most frequent causes of death worldwide and in Western society it is competing with cardiovascular disease as the number one killer. This high frequency in Western countries can be attributed to lifestyle and environmental factors, only 5-10% of all cancers are directly due to heredity. Common environmental factors leading to
Harry van Steeg, Leon H.F. Mullenders, Joost P.M. Melis, Mirjam Luijten   +3 more
openaire   +3 more sources

Base Sequence Context Effects on Nucleotide Excision Repair

Journal of Nucleic Acids, 2010
Nucleotide excision repair (NER) plays a critical role in maintaining the integrity of the genome when damaged by bulky DNA lesions, since inefficient repair can cause mutations and human diseases notably cancer. The structural properties of DNA lesions
Yuqin Cai, Dinshaw J. Patel, Suse Broyde, Nicholas E. Geacintov   +3 more
doaj   +1 more source

Ribonucleotides as nucleotide excision repair substrates [PDF]

DNA Repair, 2014
The incorporation of ribonucleotides in DNA has attracted considerable notice in recent years, since the pool of ribonucleotides can exceed that of the deoxyribonucleotides by at least 10-20-fold, and single ribonucleotide incorporation by DNA polymerases appears to be a common event.
Yuqin Cai, Nicholas E. Geacintov, Suse Broyde   +2 more
openaire   +3 more sources

Genome-wide excision repair in Arabidopsis is coupled to transcription and reflects circadian gene expression patterns

Nature Communications, 2018
Plants use nucleotide excision repair to maintain genome integrity in response to damage caused by stresses such as UV radiation. Here Oztas et al. use genome-wide profiling to show that excision repair in Arabidopsis is strongly coupled to transcription
Onur Oztas, Christopher P. Selby, Aziz Sancar, Ogun Adebali   +3 more
doaj   +1 more source

Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice

npj Aging and Mechanisms of Disease, 2020
Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves
Zhonghe Ke, Denis Firsanov, Brianna Spencer, Andrei Seluanov, Vera Gorbunova   +4 more
doaj   +1 more source

Emerging Roles of Post-Translational Modifications in Nucleotide Excision Repair

Cells, 2020
Nucleotide excision repair (NER) is a versatile DNA repair pathway which can be activated in response to a broad spectrum of UV-induced DNA damage, such as bulky adducts, including cyclobutane-pyrimidine dimers (CPDs) and 6–4 photoproducts (6–4PPs ...
Barbara N. Borsos, Hajnalka Majoros, Tibor Pankotai   +2 more
doaj   +1 more source

Role of Base Excision Repair Pathway in the Processing of Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs

Frontiers in Cell and Developmental Biology, 2021
Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB).
Yeldar Baiken, Yeldar Baiken, Yeldar Baiken, Damira Kanayeva, Sabira Taipakova, Regina Groisman, Alexander A. Ishchenko, Dinara Begimbetova, Bakhyt Matkarimov, Murat Saparbaev, Murat Saparbaev   +10 more
doaj   +1 more source

Nucleotide excision repair is a potential therapeutic target in multiple myeloma

Leukemia, 2017
Despite the development of novel drugs, alkylating agents remain an important component of therapy in multiple myeloma (MM). DNA repair processes contribute towards sensitivity to alkylating agents and therefore we here evaluate the role of nucleotide ...
R. Szalat, M. Samur, M. Fulciniti, Michael A. Lopez, P. Nanjappa, A. Cleynen, A. Cleynen, Kenneth Wen, Shaji Kumar, T. Perini, Anne S. Calkins, E. Reznichenko, D. Chauhan, Y. Tai, M. Shammas, K. C. Anderson, J. Fermand, Bertrand Arnulf, H. Avet-Loiseau, J. Lazaro, Nikhil C. Munshi, Nikhil C. Munshi   +21 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Oxidized nucleotide insertion by pol β confounds ligation during base excision repair

Nature Communications, 2017
Oxidative stress in cells can lead to accumulation of reactive oxygen species and oxidation of DNA precursors. Oxidized purine nucleotides can be inserted into DNA during replication and repair.
Melike Çağlayan, J. Horton, Da-Peng Dai, Donna F. Stefanick, Samuel H. Wilson   +4 more
semanticscholar   +1 more source