Results 41 to 50 of about 98,783 (332)
PCAF/GCN5-Mediated Acetylation of RPA1 Promotes Nucleotide Excision Repair
Cell Reports, 2017 The RPA complex can integrate multiple stress signals into diverse responses by activating distinct DNA repair pathways. However, it remains unclear how RPA1 elects to activate a specific repair pathway during different types of DNA damage.
Meimei Zhao +11 more
doaj +1 more source
Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition [PDF]
, 2012 The structure-specific endonuclease activity of the human XPF–ERCC1 complex is essential for a number of DNA processing mechanisms that help to maintain genomic integrity.
Bowles, M. +5 more
core +1 more source
Nature Communications, 2018 Plants use nucleotide excision repair to maintain genome integrity in response to damage caused by stresses such as UV radiation. Here Oztas et al. use genome-wide profiling to show that excision repair in Arabidopsis is strongly coupled to transcription
Onur Oztas +3 more
doaj +1 more source
Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
npj Aging and Mechanisms of Disease, 2020 Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves
Zhonghe Ke +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB).
Yeldar Baiken +10 more
doaj +1 more source
Cloning and characterisation of the Schizosaccharomyces pombe rad32 gene: A gene required for repair of double strand break and recombination [PDF]
, 1995 A new Schizosaccharomyces pombe mutant (rad32) which is sensitive to gamma and UV irradiation is described. Pulsed field gel electrophoresis of DNA from irradiated cells indicates that the rad32 mutant, in comparison to wild type cells, has decreased ...
Nasim, Anwar +3 more
core +2 more sources
Heritage and Sustainable Development, 2020 The UV irradiation is a major DNA damaging factor in plants. Arabidopsis thaliana uses various repair pathways for these kinds of DNA lesions. One of them is the nucleotide excision repair pathway.
Mohamed Ragab Abdel Gawwad +1 more
doaj +1 more source
DNA Repair Repertoire of the Enigmatic Hydra
Frontiers in Genetics, 2021 Since its discovery by Abraham Trembley in 1744, hydra has been a popular research organism. Features like spectacular regeneration capacity, peculiar tissue dynamics, continuous pattern formation, unique evolutionary position, and an apparent lack of ...
Apurva Barve +4 more
doaj +1 more source
Effect of DNA repair deficiencies on the cytotoxicity of resveratrol [PDF]
, 2015 Numerous preclinical studies have shown that the naturally-occurring polyphenol resveratrol may produce health-beneficial effects in a variety of disorders, including cancer, diabetes, Alzheimer, and cardiovascular diseases.
Burgos Morón, Estefanía +5 more
core
Cloning and characterisation of the S.pombe rad15 gene, a homologue to the S.cerevisiae RAD3 and human ERCC2 genes [PDF]
, 1992 The RAD3 gene of Saccharomyces cerevisiae encodes an ATP-dependent 5' - 3' DNA helicase, which is involved in excision repair of ultraviolet radiation damage.
Alan R. Lehmann +6 more
core +3 more sources