Nucleotide Metabolism Behind Epigenetics [PDF]
Frontiers in Endocrinology, 2021 The mechanisms of epigenetic gene regulation—histone modifications, chromatin remodeling, DNA methylation, and noncoding RNA—use metabolites as enzymatic cofactors and substrates in reactions that allow chromatin formation, nucleotide biogenesis ...
Tamaki Suganuma, Jerry L. Workman
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Integrated transcriptomic and metabolomic analysis reveals the effects of EMMPRIN on nucleotide metabolism and 1C metabolism in AS mouse BMDMs [PDF]
Frontiers in Molecular BiosciencesBackgroundExtracellular matrix metalloproteinase inducer (EMMPRIN) has been considered as a key promoting factor in atherosclerosis (AS). Some studies have shown that regulating EMMPRIN expression in bone marrow-derived macrophages (BMDMs) of ApoE ...
Yun Zhang +10 more
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Transcriptomic profiling identifies a nucleotide metabolism-related signature with prognostic power in gliomas [PDF]
Translational OncologyObjective: Nucleotide metabolic reprogramming as a hallmark of cancer is closely related to the occurrence and progression of cancer. We aimed to comprehensively analyze the nucleotide metabolism-related gene set and clinical significance in gliomas ...
Ai-Qin Chen +3 more
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Editorial: Targeting nucleotide metabolism for enhancing antitumor immunity [PDF]
Frontiers in ImmunologyJun Wu +7 more
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The Intersection of Purine and Mitochondrial Metabolism in Cancer
Cells, 2021 Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto De Vitto +3 more
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Single nucleotide polymorphisms of one-carbon metabolism and cancers of the esophagus, stomach, and liver in a Chinese population. [PDF]
, 2014 One-carbon metabolism (folate metabolism) is considered important in carcinogenesis because of its involvement in DNA synthesis and biological methylation reactions.
Baecker, Aileen +13 more
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Digital Insights Into Nucleotide Metabolism and Antibiotic Treatment Failure
Frontiers in Digital Health, 2021 Nucleotide metabolism plays a central role in bacterial physiology, producing the nucleic acids necessary for DNA replication and RNA transcription. Recent studies demonstrate that nucleotide metabolism also proactively contributes to antibiotic-induced ...
Allison J. Lopatkin +4 more
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Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy
Journal of Hematology & Oncology, 2022 Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but also exert serious side effects. With in-depth studies of nucleotide metabolism, our understanding of nucleotide metabolism in tumors has revealed their non ...
Huai-liang Wu +5 more
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Beyond Moco Biosynthesis―Moonlighting Roles of MoaE and MOCS2
Molecules, 2022 Molybdenum cofactor (Moco) biosynthesis requires iron, copper, and ATP. The Moco-containing enzyme sulfite oxidase catalyzes terminal oxidation in oxidative cysteine catabolism, and another Moco-containing enzyme, xanthine dehydrogenase, functions in ...
Tamaki Suganuma
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Frontiers in Plant Science, 2023 In Arabidopsis seedlings, inhibition of aspartate transcarbamoylase (ATC) and de novo pyrimidine synthesis resulted in pyrimidine starvation and developmental arrest a few days after germination.
Robert D. Slocum +2 more
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