Results 31 to 40 of about 630,925 (284)

Metabolic Promiscuity of an Orphan Small Alarmone Hydrolase Facilitates Bacterial Environmental Adaptation

mBio, 2022
Small alarmone hydrolases (SAHs) are alarmone metabolizing enzymes found in both metazoans and bacteria. In metazoans, the SAH homolog Mesh1 is reported to function in cofactor metabolism by hydrolyzing NADPH to NADH.
Danny K. Fung, Kaihong Bai, Jin Yang, Xiaoli Xu, David M. Stevenson, Daniel Amador-Noguez, Laixin Luo, Jue D. Wang   +7 more
doaj   +1 more source

Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster? [PDF]

, 2019
Distinct from normal differentiated tissues, cancer cells reprogram nutrient uptake and utilization to accommodate their elevated demands for biosynthesis and energy production.
Jiang, Jie, Srivastava, Sankalp, Zhang, Ji   +2 more
core   +1 more source

IGFBP2 from a novel copper metabolism-associated biomarker promoted glioma progression and response to immunotherapy

Frontiers in Immunology, 2023
IntroductionCopper metabolism encompasses all cellular metabolic processes involving copper ions and plays a significant role in the pathogenesis of diseases, including cancer.
Qisheng Luo, Junhong Zhuang, Dandan Zheng, Changfeng Miao, Hongcheng Luo, Jun Peng, Chuanhua Zheng, Chengjian Qin, Chuanliu Lan, Meiqin Chen, Ying Xia, Deyou Huang, Zigui Chen   +12 more
doaj   +1 more source

Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]

, 2011
Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core   +1 more source

Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia

Frontiers in Pharmacology, 2022
Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens, has a good anti-leukemia effect, but its key target and mechanism remains unclear.
Wang-Jing Zhong, Lingdi Ma, Lingdi Ma, Fanfan Yang, Jialin Cao, Junyu Tan, Bohong Li   +6 more
doaj   +1 more source

Single nucleotide polymorphisms from Theobroma cacao expressed sequence tags associated with witches' broom disease in cacao [PDF]

, 2009
In order to increase the efficiency of cacao tree resistance to witches¿ broom disease, which is caused by Moniliophthora perniciosa (Tricholomataceae), we looked for molecular markers that could help in the selection of resistant cacao genotypes.
Carels, Nicolas, Cascardo, Julio Cezar M., Gaiotto, Fernanda Amato, Gesteira, Abelmon, Gramacho, Karina Peres, Lima, Leila S., Lopes, Uilson Vanderlei, Micheli, Fabienne, Novais, R., Pires, José Luis, Zaidan, Humberto A.   +10 more
core   +1 more source

SWI/SNF regulates a transcriptional programme that induces senescence to prevent liver cancer [PDF]

, 2016
Oncogene-induced senescence (OIS) is a potent tumour suppressor mechanism. To identify senescence regulators relevant to cancer, we screened an shRNA library targeting genes deleted in hepatocellular carcinoma (HCC).
Banito, A, Carroll, T, Deswal, S, Garcia-Escudero, R, Ghamarlingam, G, Gil, J, Gonzalez Meljem, JM, Hohmeyer, A, Khan, S, Klotz, S, Martin, N, Martinez-Barbero, JP, Pedro, J, Raguz, S, Tordella, L, Zender, L, Zuber, J   +16 more
core   +2 more sources

Integrating Network Pharmacology and Metabolomics Study on Anti-rheumatic Mechanisms and Antagonistic Effects Against Methotrexate-Induced Toxicity of Qing-Luo-Yin

Frontiers in Pharmacology, 2018
Qing-Luo-Yin (QLY) is a traditional Chinese medicine (TCM) formula used to treat Hot Syndrome-related rheumatoid arthritis (RA). Previously, we uncovered partial mechanisms involved in the therapeutic actions of QLY on RA.
Jian Zuo, Xin Wang, Yang Liu, Jing Ye, Qingfei Liu, Yan Li, Shao Li   +6 more
doaj   +1 more source

Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance. [PDF]

, 2014
Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed
Bordbar, Aarash, Jamshidi, Neema, Palsson, Bernhard Ø, Rahmanian, Sorena, Thomas, Alex   +4 more
core   +2 more sources

Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity

Life Science Alliance, 2022
The tumor suppressor protein p53 inhibits ferroptosis by reducing the consumption of glutathione in nucleotide biosynthesis. Nucleotide synthesis is a metabolically demanding process essential for DNA replication and other processes in the cell.
Amy Tarangelo, Jason Rodencal, Joon Tae Kim, Leslie Magtanong, Jonathan Z Long, Scott J Dixon   +5 more
doaj   +1 more source