Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy
Journal of Hematology & Oncology, 2022 Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but also exert serious side effects. With in-depth studies of nucleotide metabolism, our understanding of nucleotide metabolism in tumors has revealed their non ...
Huai-liang Wu +5 more
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Nucleotide metabolism: a pan-cancer metabolic dependency
Nature Reviews Cancer, 2023 Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and use of nucleotide triphosphates is a critical and universal metabolic dependency of cancer cells across different cancer types and genetic backgrounds. Many of the aggressive behaviours of cancer cells, including uncontrolled proliferation, chemotherapy resistance,
Nicholas J. Mullen, Pankaj K. Singh
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Integrated transcriptomic and metabolomic analysis reveals the effects of EMMPRIN on nucleotide metabolism and 1C metabolism in AS mouse BMDMs [PDF]
Frontiers in Molecular BiosciencesBackgroundExtracellular matrix metalloproteinase inducer (EMMPRIN) has been considered as a key promoting factor in atherosclerosis (AS). Some studies have shown that regulating EMMPRIN expression in bone marrow-derived macrophages (BMDMs) of ApoE ...
Yun Zhang +10 more
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Transcriptomic profiling identifies a nucleotide metabolism-related signature with prognostic power in gliomas [PDF]
Translational OncologyObjective: Nucleotide metabolic reprogramming as a hallmark of cancer is closely related to the occurrence and progression of cancer. We aimed to comprehensively analyze the nucleotide metabolism-related gene set and clinical significance in gliomas ...
Ai-Qin Chen +3 more
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The Intersection of Purine and Mitochondrial Metabolism in Cancer
Cells, 2021 Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto De Vitto +3 more
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Digital Insights Into Nucleotide Metabolism and Antibiotic Treatment Failure
Frontiers in Digital Health, 2021 Nucleotide metabolism plays a central role in bacterial physiology, producing the nucleic acids necessary for DNA replication and RNA transcription. Recent studies demonstrate that nucleotide metabolism also proactively contributes to antibiotic-induced ...
Allison J. Lopatkin +4 more
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Metabolites, 2023 Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. The in-depth study of genes and metabolites related to nucleotide metabolism will provide new ideas for predicting the prognosis of HCC patients.
Tianfu Wei +8 more
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Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival
mBio, 2021 Epstein-Barr virus (EBV) is associated with 200,000 cancers annually, including B-cell lymphomas in immunosuppressed hosts. Hypomorphic mutations of the de novo pyrimidine synthesis pathway enzyme cytidine 5′ triphosphate synthase 1 (CTPS1) suppress cell-
Jin Hua Liang +5 more
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Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy
Microorganisms, 2022 Emerging and re-emerging viruses have been a challenge in public health in recent decades. Host-targeted antivirals (HTA) directed at cellular molecules or pathways involved in virus multiplication represent an interesting strategy to combat viruses ...
Claudia Soledad Sepúlveda +2 more
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Editorial: Targeting nucleotide metabolism for enhancing antitumor immunity [PDF]
Frontiers in ImmunologyJun Wu +7 more
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