Results 41 to 50 of about 621,729 (284)

Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease

Frontiers in Neuroscience, 2021
Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich, Melissa Talita Wiprich, Carla Denise Bonan, Carla Denise Bonan, Carla Denise Bonan   +4 more
doaj   +1 more source

Genome-wide analysis of 30 -untranslated regions supports the existence of post-transcriptional regulons controlling gene expression in trypanosomes [PDF]

, 2013
In eukaryotic cells, a group of messenger ribonucleic acids (mRNAs) encoding functionally interrelated proteins together with the trans-acting factors that coordinately modulate their expression is termed a post-transcriptional regulon, due to their ...
Agüero, Fernan Gonzalo, Carmona, Santiago Javier, de Gaudenzi, Javier Gerardo, Frasch, Alberto Carlos C.   +3 more
core   +3 more sources

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. [PDF]

, 2017
The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation.
Braas, Daniel, Christofk, Heather, Clark, Peter M, Ding, Xueqin, Dunham, Christopher, Fu, Kai, Gimzewski, James K, Kurdistani, Siavash K, Lusis, Aldons J, Minami, Itsunari, Morselli, Marco, Nakano, Atsushi, Nakano, Haruko, Nakatsuji, Norio, Pappoe, Herman, Pellegrini, Matteo, Reue, Karen, Ribalet, Bernard, Sagadevan, Addelynn, Stieg, Adam Z, Vergnes, Laurent, Wu, Xiuju   +21 more
core   +2 more sources

A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD

Molecules, 2023
CAD is a 1.5 MDa hexameric protein with four enzymatic domains responsible for initiating de novo biosynthesis of pyrimidines nucleotides: glutaminase, carbamoyl phosphate synthetase, aspartate transcarbamoylase (ATC), and dihydroorotase.
Francisco del Caño-Ochoa, Antonio Rubio-del-Campo, Santiago Ramón-Maiques   +2 more
doaj   +1 more source

Nucleotide Metabolism in Plants [PDF]

Plant Physiology, 2019
[no abstract available]
Claus-Peter Witte, Marco Herde
openaire   +2 more sources

Regulation of metabolism by miR-378 [PDF]

, 2014
The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression.
Carrer, Michele, Olson, Eric N.
core   +1 more source

Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism [PDF]

, 2011
To be viable, organisms possess a number of (deoxy)nucleotide phosphohydrolases, which hydrolyze these nucleotides removing them from the active NTP and dNTP pools. Deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP,
Davies, Oluwafemi, Malys, Naglis, Mendes, Pedro, Smallbone, Kieran   +3 more
core   +2 more sources

Integrating Network Pharmacology and Metabolomics Study on Anti-rheumatic Mechanisms and Antagonistic Effects Against Methotrexate-Induced Toxicity of Qing-Luo-Yin

Frontiers in Pharmacology, 2018
Qing-Luo-Yin (QLY) is a traditional Chinese medicine (TCM) formula used to treat Hot Syndrome-related rheumatoid arthritis (RA). Previously, we uncovered partial mechanisms involved in the therapeutic actions of QLY on RA.
Jian Zuo, Xin Wang, Yang Liu, Jing Ye, Qingfei Liu, Yan Li, Shao Li   +6 more
doaj   +1 more source

Non-Target Metabolomics Reveals Changes in Metabolite Profiles in Distant Hybrid Incompatibility Between Paeonia sect. Moutan and P. lactiflora

Plants
Peonies are globally renowned ornamental plants, and distant hybridization is a key method for breeding new varieties, though it often faces cross-incompatibility challenges.
Wenqing Jia, Yingyue Yu, Zhaorong Mi, Yan Zhang, Guodong Zhao, Yingzi Guo, Zheng Wang, Erqiang Wang, Songlin He   +8 more
doaj   +1 more source

Genome-Wide Footprints of Pig Domestication and Selection Revealed through Massive Parallel Sequencing of Pooled DNA [PDF]

, 2011
Background Artificial selection has caused rapid evolution in domesticated species. The identification of selection footprints across domesticated genomes can contribute to uncover the genetic basis of phenotypic diversity.
Amaral, A.J., Crooijmans, R.P.M.A., Ferretti, L., Groenen, M.A.M., Megens, H.J.W.C., Nie, H., Perez-Enciso, M., Ramos-Onsins, S.E., Schook, L.B.   +8 more
core   +2 more sources