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DNA as an information storage system is simple and at the same time complex owing to the various different arrangements of the four natural nucleotides.[1] The DNA synthesis by DNA polymerases is intriguing, since these enzymes are able to catalyze the elongation of the primer strand by recognizing the DNA template and selecting the corresponding ...
Baccaro, Anna+2 more
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Nucleotide-decorated AuNPs as probes for nucleotide-binding proteins [PDF]
AbstractGold nanoparticles (AuNPs) decorated with biologically relevant molecules have variety of applications in optical sensing of bioanalytes. Coating AuNPs with small nucleotides produces particles with high stability in water, but functionality-compatible strategies are needed to uncover the full potential of this type of conjugates.
Maciej Mazur+7 more
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Nucleotides: Structure and Properties [PDF]
Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
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Gastroprotective effects of oral nucleotide administration [PDF]
BACKGROUND AND AIMS: Nucleotides form the building blocks of DNA and are marketed as dietary supplements, alone or in combination with other ingredients, to promote general health.
Belo, A+4 more
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Determination of total potentially available nucleosides in bovine milk [PDF]
Bovine colostrum and milk samples were collected from two herds over the course of the first month post-partum, pooled for each herd by stage of lactation and total potentially available nucleosides were determined.
Gill, Brendon D.+2 more
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Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism [PDF]
To be viable, organisms possess a number of (deoxy)nucleotide phosphohydrolases, which hydrolyze these nucleotides removing them from the active NTP and dNTP pools. Deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP,
Davies, Oluwafemi+3 more
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Deuterated nucleotides as chemical probes of RNA structure: a detailed protocol for the enzymatic synthesis of a complete set of nucleotides specifically deuterated at ribose carbons [PDF]
We describe here a detailed protocol for the synthesis of ribonucleotides specifically deuterated at each ribose carbon atom. We synthesized 20 specifically deuterated ribonucleotides: ATP, CTP, GTP, and UTP, each of which contained one of five ...
Azad, Robert+2 more
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There has been much speculation about the types of molecules that were present in the first living forms. Recent discoveries show that RNA is a more versatile molecule than was previously believed, but whether it was ever able, for example, to synthesize its own monomers from available precursors is not yet known.
D. A. Usher, M.C. Needels
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Comment on "Characterization of the tunneling conductance across DNA bases" [PDF]
In a recent article, Zikic {\it et al.} [Phys. Rev. E {\bf 74}, 011919 (2006)] present first-principles calculations of the DNA nucleotides electrical conductance.
Di Ventra, Massimiliano+2 more
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Cryptic Variation in the Human Mutation Rate [PDF]
The mutation rate is known to vary between adjacent sites within the human genome as a consequence of context, the most well-studied example being the influence of CpG dinucelotides.
Eyre-Walker, Adam+2 more
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