Results 11 to 20 of about 588,819 (292)

Hypoxanthine-Guanine Phosphoribosyltransferase/adenylate Kinase From Zobellia galactanivorans: A Bifunctional Catalyst for the Synthesis of Nucleoside-5′-Mono-, Di- and Triphosphates

Frontiers in Bioengineering and Biotechnology, 2020
In our search for novel biocatalysts for the synthesis of nucleic acid derivatives, we found a good candidate in a putative dual-domain hypoxanthine-guanine phosphoribosyltransferase (HGPRT)/adenylate kinase (AMPK) from Zobellia galactanivorans (ZgHGPRT ...
Javier Acosta, Jon Del Arco, Maria Luisa Del Pozo, Beliña Herrera-Tapias, Vicente Javier Clemente-Suárez, Vicente Javier Clemente-Suárez, José Berenguer, Aurelio Hidalgo, Jesús Fernández-Lucas, Jesús Fernández-Lucas   +9 more
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CTP Synthase 2 From Arabidopsis thaliana Is Required for Complete Embryo Development

Frontiers in Plant Science, 2021
Pyrimidine de novo synthesis is an essential pathway in all organisms. The final and rate-limiting step in the synthesis of the nucleotide cytidine triphosphate (CTP) is catalyzed by CTP synthase (CTPS), and Arabidopsis harbors five isoforms.
Daniel Hickl, David Scheuring, Torsten Möhlmann   +2 more
doaj   +1 more source

Integrated Multi-Omics Analysis for Inferring Molecular Players in Inclusion Body Myositis

Antioxidants, 2023
Inclusion body myositis (IBM) is an acquired inflammatory myopathy affecting proximal and distal muscles that leads to weakness in patients over 50.
Judith Cantó-Santos, Laura Valls-Roca, Ester Tobías, Clara Oliva, Francesc Josep García-García, Mariona Guitart-Mampel, Félix Andújar-Sánchez, Anna Esteve-Codina, Beatriz Martín-Mur, Joan Padrosa, Raquel Aránega, Pedro J. Moreno-Lozano, José César Milisenda, Rafael Artuch, Josep M. Grau-Junyent, Glòria Garrabou   +15 more
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Palladium-Catalyzed Modification of Unprotected Nucleosides, Nucleotides, and Oligonucleotides

Molecules, 2015
Synthetic modification of nucleoside structures provides access to molecules of interest as pharmaceuticals, biochemical probes, and models to study diseases.
Kevin H. Shaughnessy
doaj   +1 more source

Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma

Frontiers in Oncology, 2021
Metabolic dysfunctions enabling increased nucleotide biosynthesis are necessary for supporting malignant proliferation. Our investigations indicate that upregulation of fatty acid synthase (FASN) and de novo lipogenesis, commonly observed in many cancers,
Dashnamoorthy Ravi, Dashnamoorthy Ravi, Afshin Beheshti, Afshin Beheshti, Nasséra Abermil, Frederick Lansigan, Frederick Lansigan, William Kinlaw, Nirupa R. Matthan, Maisarah Mokhtar, Frank C. Passero, Patrick Puliti, Patrick Puliti, Patrick Puliti, Kevin A. David, Kevin A. David, Gregory G. Dolnikowski, Xiaoyang Su, Xiaoyang Su, Ying Chen, Mahboubi Bijan, Rohan R. Varshney, Baek Kim, Baek Kim, Sandeep S. Dave, Michael C. Rudolph, Andrew M. Evens, Andrew M. Evens   +27 more
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Protein Mass and Calcium Mass of Broiler Chicken with Added Nucleotides at Different Maintenance Temperatures

Jurnal Sain Peternakan Indonesia, 2021
This study aims to examine the effect of adding nucleotides in broiler rations on the protein mass and calcium mass of broiler chicken reared at different temperatures.
I. Rahmawati, L .D. Mahfudz, S. Kismiati
doaj   +1 more source

Dietary Supplementation of Brown Seaweed and/or Nucleotides Improved Shrimp Performance, Health Status and Cold-Tolerant Gene Expression of Juvenile Whiteleg Shrimp during the Winter Season

Marine Drugs, 2021
This study was aimed to evaluate the efficiency of Sargassumpolycystum and nucleotides- supplemented diets to improve immune response and cold-tolerance of juvenile Litopenaeus vannamei.
Mohamed Abdel-Rahim, Omar Bahattab, Fatma Nossir, Yahya Al-Awthan, Riad H. Khalil, Radi Mohamed   +5 more
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Applications of nucleoside-based molecular probes for the in vivo assessment of tumour biochemistry using positron emission tomography (PET)

Brazilian Archives of Biology and Technology, 2007
Positron emission tomography (PET) is a non-invasive nuclear imaging technique. In PET, radiolabelled molecules decay by positron emission. The gamma rays resulting from positron annihilation are detected in coincidence and mapped to produce three ...
Leonard I. Wiebe
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The nucleobase analog 4-thiouracil hijacks the pyrimidine salvage pathway to inhibit Staphylococcus aureus growth

Microbiology Spectrum
Staphylococcus aureus is a leading cause of bacterial-induced mortality due to infections that are increasingly resistant to antibiotics, highlighting the need for new therapeutic strategies to treat these drug-resistant infections.
Matthew J. Munneke, Jeffrey A. Freiberg, Eric P. Skaar   +2 more
doaj   +1 more source

An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels

Frontiers in Cellular Neuroscience, 2019
P2X receptors constitute a gene family of cation channels gated by extracellular ATP. They mediate fast ionotropic purinergic signaling in neurons and non-excitable cell types in vertebrates.
Ariel R. Ase, Éric Therrien, Philippe Séguéla   +2 more
doaj   +1 more source