HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
Nature, 2016 During the early stages of infection, the HIV-1 capsid protects viral components from cytosolic sensors and nucleases such as cGAS and TREX, respectively, while allowing access to nucleotides for efficient reverse transcription.
D. Jacques +5 more
semanticscholar +1 more source
Microbiology SpectrumStaphylococcus aureus is a leading cause of bacterial-induced mortality due to infections that are increasingly resistant to antibiotics, highlighting the need for new therapeutic strategies to treat these drug-resistant infections.
Matthew J. Munneke +2 more
doaj +1 more source
An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels
Frontiers in Cellular Neuroscience, 2019 P2X receptors constitute a gene family of cation channels gated by extracellular ATP. They mediate fast ionotropic purinergic signaling in neurons and non-excitable cell types in vertebrates.
Ariel R. Ase +2 more
doaj +1 more source
mBio, 2016 Invading pathogen nucleic acids are recognized and bound by cytoplasmic (retinoic acid-inducible gene I [RIG-I]-like) and membrane-bound (Toll-like) pattern recognition receptors to activate innate immune signaling.
Ann F Durbin +3 more
semanticscholar +1 more source
The 5' untranslated region of the I factor, a long interspersed nuclear element-like retrotransposon of Drosophila melanogaster, contains an internal promoter and sequences that regulate expression [PDF]
, 1993 The I-R system of hybrid dysgenesis in Drosophila melanogaster is controlled by a long interspersed nuclear element-like retroposon, the I factor.
BUCHETON, A +3 more
core +1 more source
Enzyme-free genetic copying of DNA and RNA sequences
Beilstein Journal of Organic Chemistry, 2018 The copying of short DNA or RNA sequences in the absence of enzymes is a fascinating reaction that has been studied in the context of prebiotic chemistry.
Marilyne Sosson, Clemens Richert
doaj +1 more source
Physiological and Metabolic Responses of Leymus chinensis Seedlings to Alkali Stress
Plants, 2022 To elucidate the physiological and metabolic mechanism of perennial grass responses to alkali stress, we selected Leymus chinensis (L. chinensis), a salt-tolerant perennial rhizomatous species of the family Poaceae as experimental material.
Ge Yan +4 more
doaj +1 more source
Programmable multimetallic linear nanoassemblies of ruthenium–DNA conjugates [PDF]
, 2012 A new ruthenium–DNA conjugates family was synthesized, made up of a ruthenium complex bound to one or two identical DNA strands of 14–58 nucleotides.
Chouini-Lalanne, Nadia +5 more
core +3 more sources
Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis
Journal of Lipid ResearchA key organismal response to overnutrition involves the development of new adipocytes through the process of adipogenesis. Preadipocytes sense changes in the systemic nutrient status and metabolites can directly modulate adipogenesis.
Julia A. Pinette +16 more
doaj +1 more source
Effect of Deep Dormancy Temperature Cultivation on Meat Quality of Crucian Carp (Carassius auratus)
Foods, 2023 To extend the survival of crucian carp (Carassius auratus) during transportation, the effect of deep dormancy temperature (DDT) cultivation on the crucian carp was investigated by measuring the respiratory rate, survival time, and effect of cooling speed
Yin Zhang +6 more
doaj +1 more source