Two complementing in vivo selection systems based on CCA-trimming exonucleases as a tool to monitor, select and evaluate enzymatic features of tRNA nucleotidyltransferases [PDF]
RNA BiologytRNA nucleotidyltransferase represents a ubiquitous and essential activity that adds the indispensable CCA triplet to the 3’-end of tRNAs. To fulfill this function, the enzyme contains a set of highly conserved motifs whose coordinated interplay is ...
Karolin Wellner +5 more
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ant(6)-I Genes Encoding Aminoglycoside O-Nucleotidyltransferases Are Widely Spread Among Streptomycin Resistant Strains of Campylobacter jejuni and Campylobacter coli [PDF]
Frontiers in Microbiology, 2018 Thermotolerant Campylobacter species C. jejuni and C. coli are actually recognized as the major bacterial agent responsible for food-transmitted gastroenteritis. The most effective antimicrobials against Campylobacter are macrolides and some, but not all
María Ugarte-ruiz +2 more
exaly +7 more sources
Manipulation of mitochondrial poly(A) polymerase family proteins in Trypanosoma brucei impacts mRNA termini processing [PDF]
Frontiers in Parasitology, 2023 RNA-specific nucleotidyltransferases (rNTrs) add nontemplated nucleotides to the 3′ end of RNA. Two noncanonical rNTRs that are thought to be poly(A) polymerases (PAPs) have been identified in the mitochondria of trypanosomes – KPAP1 and KPAP2.
Clara M. Smoniewski +6 more
doaj +2 more sources
Separate Kingdoms, Same Conspiracies: Conserved Viral Strategies for Immune Evasion in Animal and Bacterial Hosts. [PDF]
MedComm (2020)MedComm, Volume 6, Issue 5, May 2025.
Wang J, He X, Li G.
europepmc +2 more sources
Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases [PDF]
Nature Communications, 2023 Purine-containing nucleotide second messengers regulate diverse cellular activities. Cyclic di-pyrimidines mediate anti-phage functions in bacteria; however, the synthesis mechanism remains elusive.
Chia-Shin Yang +5 more
doaj +2 more sources
Unlocking Enhanced Efficacy of Aminoglycoside Antibiotics Against Pseudomonas aeruginosa. [PDF]
Microb BiotechnolThis opinion article reviews the use and challenges of aminoglycosides on the Gram‐negative pathogen Pseudomonas aeruginosa and highlights recent discoveries of adjuvants and/or other compounds that potentiate the activity of these antibiotics. ABSTRACT Infectious diseases continue to be a global health burden.
Tawiah PO, Sultana S, Dahl JU.
europepmc +2 more sources
Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases
Frontiers in Genetics, 2014 The universal 3'-terminal CCA sequence of tRNA is built and/or synthesized by the CCA-adding enzyme, CTP:(ATP) tRNA nucleotidyltransferase. This RNA polymerase has no nucleic acid template, but faithfully synthesizes the defined CCA sequence on the 3 ...
Kozo Tomita, Seisuke Yamashita
exaly +3 more sources
Feedback Inhibition of Bacterial Nucleotidyltransferases by Rare Nucleotide l-Sugars Restricts Substrate Promiscuity. [PDF]
J Am Chem Soc, 2023 Zheng M, Zheng MC, Kim H, Lupoli TJ.
europepmc +2 more sources
Identification of a novel aminoglycoside nucleotidyltransferase gene in Morganella morganii from farm sewage. [PDF]
BMC MicrobiolLu J +12 more
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EMBO Molecular Medicine, 2023 Dysfunction of the endoplasmic reticulum (ER) in insulin‐producing beta cells results in cell loss and diabetes mellitus. Here we report on five individuals from three different consanguineous families with infancy‐onset diabetes mellitus and severe ...
Luke A Perera +9 more
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