Results 1 to 10 of about 8,237 (208)

ant(6)-I Genes Encoding Aminoglycoside O-Nucleotidyltransferases Are Widely Spread Among Streptomycin Resistant Strains of Campylobacter jejuni and Campylobacter coli [PDF]

open access: goldFrontiers in Microbiology, 2018
Thermotolerant Campylobacter species C. jejuni and C. coli are actually recognized as the major bacterial agent responsible for food-transmitted gastroenteritis. The most effective antimicrobials against Campylobacter are macrolides and some, but not all
Lorena Hormeño   +9 more
doaj   +3 more sources

Two complementing in vivo selection systems based on CCA-trimming exonucleases as a tool to monitor, select and evaluate enzymatic features of tRNA nucleotidyltransferases [PDF]

open access: yesRNA Biology
tRNA nucleotidyltransferase represents a ubiquitous and essential activity that adds the indispensable CCA triplet to the 3’-end of tRNAs. To fulfill this function, the enzyme contains a set of highly conserved motifs whose coordinated interplay is ...
Karolin Wellner   +5 more
doaj   +3 more sources

Kinetic analysis of rabbit liver tRNA nucleotidyltransferase.

open access: hybridJournal of Biological Chemistry, 1978
The kinetic properties of rabbit liver tRNA nucleotidyltransferase were examined. Our results indicate that incorporation of AMP into tRNA-C-C at pH 9.4 proceeds by a rapid equilibrium Random Bi Bi mechanism. This conclusion was supported by bisubstrate initial velocity studies, dead end and product inhibition, and isotope exchange at equilibrium and ...
Jeffrey A. Evans, Murray P. Deutscher
openalex   +3 more sources

Infancy‐onset diabetes caused by de‐regulated AMPylation of the human endoplasmic reticulum chaperone BiP

open access: yesEMBO Molecular Medicine, 2023
Dysfunction of the endoplasmic reticulum (ER) in insulin‐producing beta cells results in cell loss and diabetes mellitus. Here we report on five individuals from three different consanguineous families with infancy‐onset diabetes mellitus and severe ...
Luke A Perera   +9 more
doaj   +1 more source

The Battle for Survival: The Role of RNA Non-Canonical Tails in the Virus–Host Interaction

open access: yesMetabolites, 2023
Terminal nucleotidyltransferases (TENTs) could generate a ‘mixed tail’ or ‘U-rich tail’ consisting of different nucleotides at the 3′ end of RNA by non-templated nucleotide addition to protect or degrade cellular messenger RNA.
Xianghui Wen, Ahsan Irshad, Hua Jin
doaj   +1 more source

Identification of a novel aminoglycoside O-nucleotidyltransferase AadA33 in Providencia vermicola

open access: yesFrontiers in Microbiology, 2022
A novel chromosome-encoded aminoglycoside O-nucleotidyltransferase AadA33 was identified in Providencia vermicola strain P13. The AadA33 shares the highest amino acid identity of 51.28% with the function characterized AadA31.
Chunlin Feng   +20 more
doaj   +1 more source

The arms race between bacteria CBASS and bacteriophages

open access: yesFrontiers in Immunology, 2023
The Bacterial Cyclic oligonucleotide-Based Anti-phage Signaling System (CBASS) is an innate immune system that induces cell suicide to defend against phage infections.
Lan Wang   +5 more
doaj   +1 more source

Promiscuous splicing-derived hairpins are dominant substrates of tailing-mediated defense of miRNA biogenesis in mammals

open access: yesCell Reports, 2023
Summary: Canonical microRNA (miRNA) hairpins are processed by the RNase III enzymes Drosha and Dicer into ∼22 nt RNAs loaded into an Argonaute (Ago) effector.
Seungjae Lee   +10 more
doaj   +1 more source

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