Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes [PDF]
, 2015 Until relatively recently, DNA primases were viewed simply as a class of proteins that synthesize short RNA primers requisite for the initiation of DNA replication.
Aidan J. Doherty +17 more
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Cell Reports, 2023 Summary: Canonical microRNA (miRNA) hairpins are processed by the RNase III enzymes Drosha and Dicer into ∼22 nt RNAs loaded into an Argonaute (Ago) effector.
Seungjae Lee +10 more
doaj
PLoS Genetics, 2017 The emergence and spread of antibiotic resistance among Acinetobacter spp. have been investigated extensively. Most studies focused on the multiple antibiotic resistance genes located on plasmids or genomic resistance islands.
Gang Zhang +7 more
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Solution, solid-phase, and fluorous-phase synthesis of carbohydrates and production of carbohydrate microarrays [PDF]
, 2006 This dissertation focuses on two specific aspects of the chemistry of carbohydrates. The first is the solid- and fluorous-phase synthesis of oligosaccharides and their use in forming microarrays.
Ko, Kwang-Seuk
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Amikacin: Uses, Resistance, and Prospects for Inhibition
Molecules, 2017 Aminoglycosides are a group of antibiotics used since the 1940s to primarily treat a broad spectrum of bacterial infections. The primary resistance mechanism against these antibiotics is enzymatic modification by aminoglycoside-modifying enzymes that are
Maria S. Ramirez, Marcelo E. Tolmasky
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Unusual evolution of a catalytic core element in CCA-adding enzymes [PDF]
, 2010 CCA-adding enzymes are polymerases existing in two distinct enzyme classes that both synthesize the C-C-A triplet at tRNA 3′-ends. Class II enzymes (found in bacteria and eukaryotes) carry a flexible loop in their catalytic core required for switching ...
Betat, Heike +6 more
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Discovery of Three Toxic Proteins of Klebsiella Phage fHe-Kpn01 [PDF]
, 2020 The lytic phage, fHe-Kpn01 was isolated from sewage water using an extended-spectrum beta-lactamase-producing strain of Klebsiella pneumoniae as a host. The genome is 43,329 bp in size and contains direct terminal repeats of 222 bp.
Pajunen, Maria I. +4 more
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Bacteriophage antidefense genes that neutralize TIR and STING immune responses
Cell Reports, 2023 Summary: Programmed cell suicide of infected bacteria, known as abortive infection (Abi), serves as an immune defense strategy to prevent the propagation of bacteriophage viruses.
Peiyin Ho +5 more
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Biophysical and enzymatic properties of aminoglycoside adenylyltransferase AadA6 from Pseudomonas aeruginosa [PDF]
, 2015 The gene coding for the aminoglycoside adenylyltransferase (aadA6) from a clinical isolate of Pseudomonas aeruginosa was cloned and expressed in Escherichia coli strain BL21(DE3)pLysS.
Akdemir, G. +9 more
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Emergence of five kinds of aminoglycoside-modifying enzyme genes simultaneously in a strain of multidrugresistant Escherichia coli in China [PDF]
, 2012 A strain of Escherichia coli was positive for 5 aminoglycoside modifying enzyme genes (aac(3)-I, aac(6′)-Ib-cr, ant(3′)-1, aadA5, and aph(3′)-I) in PCR assays.
Wang-Sheng, Z. +2 more
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