Results 41 to 50 of about 8,237 (208)

Manipulation of mitochondrial poly(A) polymerase family proteins in Trypanosoma brucei impacts mRNA termini processing

Frontiers in Parasitology
RNA-specific nucleotidyltransferases (rNTrs) add nontemplated nucleotides to the 3′ end of RNA. Two noncanonical rNTRs that are thought to be poly(A) polymerases (PAPs) have been identified in the mitochondria of trypanosomes – KPAP1 and KPAP2.
Clara M. Smoniewski, Poorya Mirzavand Borujeni, Marshall Hampton, Austin Petersen, Sean P. Faacks, Reza Salavati, Sara L. Zimmer   +6 more
doaj   +1 more source

Purification and Characterization of a Mutant tRNA Nucleotidyltransferase [PDF]

European Journal of Biochemistry, 1980
tRNA nucleotidyltransferase has been extensively purified from a mutant strain of Escherichia coli which displays greatly decreased AMP incorporation, but normal CMP incorporation. The defect in AMP incorporation is retained throughout the purification of the mutant protein. The mutant protein behaves identically to the wild‐type protein with regard to
R G, McGann, M P, Deutscher
openaire   +2 more sources

Amikacin: Uses, Resistance, and Prospects for Inhibition

Molecules, 2017
Aminoglycosides are a group of antibiotics used since the 1940s to primarily treat a broad spectrum of bacterial infections. The primary resistance mechanism against these antibiotics is enzymatic modification by aminoglycoside-modifying enzymes that are
Maria S. Ramirez, Marcelo E. Tolmasky
doaj   +1 more source

Emergence of 4',4"-aminoglycoside nucleotidyltransferase in enterococci [PDF]

Antimicrobial Agents and Chemotherapy, 1990
Enterococcus faecium BM4102 was resistant to macrolide-lincosamide-streptogramin B-type (MLS) antibiotics; tetracycline-minocycline; and high levels of kanamycin, neomycin, tobramycin, and dibekacin but not gentamicin. This aminoglycoside resistance phenotype is new in enterococci.
C, Carlier, P, Courvalin
openaire   +2 more sources

Molecular cloning of a novel glucuronokinase/putative pyrophosphorylase from zebrafish acting in an UDP-glucuronic acid salvage pathway.

PLoS ONE, 2014
In animals, the main precursor for glycosaminoglycan and furthermore proteoglycan biosynthesis, like hyaluronic acid, is UDP-glucuronic acid, which is synthesized via the nucleotide sugar oxidation pathway.
Roman Gangl, Robert Behmüller, Raimund Tenhaken   +2 more
doaj   +1 more source

The potato cyst nematode Globodera pallida overcomes major potato resistance through selection on standing variation at a single locus

New Phytologist, EarlyView.
Summary Globodera pallida poses a major threat to potato production, with management strategies primarily relying on genetic resistance. However, increasing virulence in field populations across Western Europe raises major concerns for G. pallida control.
Arno S. Schaveling, Dennie M. te Molder, Paul Heeres, Joris J. M. van Steenbrugge, Stefan J. S. van de Ruitenbeek, Casper C. van Schaik, Sven van den Elsen, Geert Smant, Mark G. Sterken   +8 more
wiley   +1 more source

Thermodynamics of binding of divalent magnesium and manganese to uridine phosphates: implications for diabetes-related hypomagnesaemia and carbohydrate biocatalysis

Chemistry Central Journal, 2008
Background Although the necessity of divalent magnesium and manganese for full activity of sugar nucleotidyltransferases and glycosyltransferases is well known, the role of these metal cations in binding the substrates (uridine 5'-triphosphate, glucose-1-
Pohl Nicola L, Camci-Unal Gulden, Zea Corbin J   +2 more
doaj   +1 more source

Clinical Efficacy of Traditional Chinese Medicine Chaihu‐Guizhi‐Ganjiang Decoction Combined With Danggui‐Shaoyao‐San for the Treatment of Oligomenorrhea: A Prospective, Open‐Label Clinical Study

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Objective To assess the efficacy and safety of Chaihu‐Guizhi‐Ganjiang decoction (CGGJD) combined with Danggui‐Shaoyao‐San (DS) in oligomenorrhea treatment. Methods In this prospective open‐label trial, 35 oligomenorrhea patients (30–40 years) received CGGJD‐DS for 3 months, followed by a 2‐month follow‐up.
Mei Yu, Gui-Yan Liu, Wen-Xuan Zhou, Zhao-Hua Liu, Lian-Tao Li, Jin Chai   +5 more
wiley   +1 more source

Characterization of the Microbial Resistome in Conventional and “Raised Without Antibiotics” Beef and Dairy Production Systems

Frontiers in Microbiology, 2019
Metagenomic investigations have the potential to provide unprecedented insights into microbial ecologies, such as those relating to antimicrobial resistance (AMR).
Pablo Rovira, Tim McAllister, Steven M. Lakin, Shaun R. Cook, Enrique Doster, Noelle R. Noyes, Maggie D. Weinroth, Xiang Yang, Jennifer K. Parker, Christina Boucher, Calvin W. Booker, Dale R. Woerner, Keith E. Belk, Paul S. Morley   +13 more
doaj   +1 more source

Integrative Bioinformatics and Machine Learning Identify Novel Diagnostic Biomarkers and Molecular Mechanisms in Sjögren’s Syndrome

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Sjögren’s syndrome (SS) is a chronic autoimmune disorder characterized by significant diagnostic challenges due to nonspecific symptoms and a lack of reliable biomarkers, often resulting in delayed diagnosis and suboptimal patient management.
Hua Xu, Yong Liu, Yuyin Song, Yifan Zheng, Haifeng Jing, Yanfei Gao, Depeng Zhou, Xiang Chi, Jia Chen, Zhengrui Li   +9 more
wiley   +1 more source