Results 61 to 70 of about 7,722 (193)
Helicobacter, Volume 30, Issue 2, March/April 2025.ABSTRACT Background Helicobacter pylori (H. pylori) has been identified as a type I carcinogen and contributes to a high rate of gastric cancer (GC), especially in Eastern Asia. Extracellular vesicles (EVs) have the potential to be used to detect various cancer types and diseases. However, the protein markers in EVs for the prognosis of H.
Phawinee Subsomwong +5 more
wiley +1 more source
Heterozygous PNPT1 Variants Cause a Sensory Ataxic Neuropathy
European Journal of Neurology, Volume 32, Issue 2, February 2025.ABSTRACT Background Biallelic variants in polyribonucleotide‐nucleotidyltransferase‐1 (PNPT1) have been associated with a range of phenotypes from syndromic hearing loss to Leigh's syndrome. More recently, heterozygous variants in PNPT1, have been reported in three families with cerebellar ataxia and prominent sensory neuropathy.
Saif Haddad +10 more
wiley +1 more source
Characterization of wild and captive baboon gut microbiota and their antibiotic resistomes [PDF]
, 2018 Antibiotic exposure results in acute and persistent shifts in the composition and function of microbial communities associated with vertebrate hosts.
Boolchandani, Manish +9 more
core +2 more sources
Transcription Kinetics in the Coronavirus Life Cycle
WIREs RNA, Volume 16, Issue 1, January/February 2025.The steps involved in a Coronavirus infection are interconnected and exhibit complex kinetics, with some processes depending on each other, while others occur independently. Understanding the basic kinetics of major processes like translation, transcription, and virion assembly in the Coronavirus life cycle adds temporal resolution to the classical ...
Katarzyna Grelewska‐Nowotko +2 more
wiley +1 more source
Two Classes of Silencing RNAs Move between Caenorhabditis elegans Tissues [PDF]
, 2013 Organism-wide RNA interference (RNAi) is due to the transport of mobile silencing RNA throughout the organism, but the identities of these mobile RNA species in animals are unknown. Here, we present genetic evidence that both the initial double-stranded
Garcia, Giancarlo +2 more
core +1 more source
Adaptor‐Mediated Trafficking of Tank Binding Kinase 1 During Diverse Cellular Processes
Traffic, Volume 26, Issue 1-3, January/March 2025.TBK1 and its adaptor signaling play a crucial role in diverse biological processes, including innate immunity, selective autophagy, and mitosis. ABSTRACT The serine/threonine kinase, Tank Binding Kinase 1 (TBK1), drives distinct cellular processes like innate immune signaling, selective autophagy, and mitosis. It is suggested that the translocation and
Swagatika Paul +4 more
wiley +1 more source
Deinococcus radiodurans RNA ligase exemplifies a novel ligase clade with a distinctive N-terminal module that is important for 5′-PO(4) nick sealing and ligase adenylylation but dispensable for phosphodiester formation at an adenylylated nick [PDF]
, 2007 Deinococcus radiodurans RNA ligase (DraRnl) is a template-directed ligase that seals nicked duplexes in which the 3′-OH strand is RNA. DraRnl is a 342 amino acid polypeptide composed of a C-terminal adenylyltransferase domain fused to a distinctive 126 ...
Raymond, Amy, Shuman, Stewart
core +2 more sources
Aquaculture Research, Volume 2025, Issue 1, 2025.Background:Klebsiella mr‐1S, a newly emerging pathogen that poses a substantial threat to public health by inducing severe infectious diseases, has been detected in Macrobrachium rosenbergii for the first time in our prior investigation. Given its potential for environmental adaptation and genomic evolution, this study aims to delve into these aspects ...
Yang Xu +4 more
wiley +1 more source
Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing [PDF]
, 2013 BACKGROUND: The major role of enzymatic toxins that target nucleic acids in biological conflicts at all levels has become increasingly apparent thanks in large part to the advances of comparative genomics.
A Maxwell Burroughs +4 more
core +1 more source
The landscape of Arabidopsis tRNA aminoacylation
The Plant Journal, Volume 120, Issue 6, Page 2784-2802, December 2024.SUMMARY The function of transfer RNAs (tRNAs) depends on enzymes that cleave primary transcript ends, add a 3′ CCA tail, introduce post‐transcriptional base modifications, and charge (aminoacylate) mature tRNAs with the correct amino acid. Maintaining an available pool of the resulting aminoacylated tRNAs is essential for protein synthesis.
Luis F. Ceriotti +3 more
wiley +1 more source