Results 61 to 70 of about 8,017 (202)

TENT5C functions as a corepressor in the ligand‐bound glucocorticoid receptor and estrogen receptor α complexes

The FEBS Journal, EarlyView.
TENT5C is a suppressor of ERα and GR transcriptional activation. A specific LXXLL motif in TENT5C, absent in the other members of the TENT5 subfamily, mediates a stable interaction with the Ligand Binding Domain of ERα but not with that of GR.
Yin Li, Lalith Perera, Rebecca S. He, Marine Baptissart, Robert M. Petrovich, Marcos Morgan   +5 more
wiley   +1 more source

Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics

Biology Direct, 2012
Background Proteinaceous toxins are observed across all levels of inter-organismal and intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin systems implicated in intra-specific conflicts.
Zhang Dapeng, de Souza Robson F, Anantharaman Vivek, Iyer Lakshminarayan M, Aravind L   +4 more
doaj   +1 more source

Stress alters hypothalamic gene expression in adolescent male Golden hamsters

Journal of Neuroendocrinology, EarlyView.
Abstract In Golden hamsters (Mesocricetus auratus), a two‐week exposure to chronic social stress in adolescence causes acceleration of agonistic behavior, enhanced adult aggression, impaired waiting impulsivity, and higher food intake, body fat, and long‐term increased body weight.
Kevin M. Moran, Tyler M. Milewski, James P. Curley, Yvon Delville   +3 more
wiley   +1 more source

Analysis of hepatitis B virus integration identifies KMT2B as a novel cancer‐related gene in pancreatic cancer

Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.
HBV DNA integrates in multiple genes including KMT2B in pancreatic cancer. KMT2B upregulation caused by HBV integration or other mechanisms promotes FYN expression via histone H3K4 trimethylation at its promoter region. Increased FYN expression activates the PI3K/Akt signalling pathway, thus driving PDAC cell proliferation, migration and invasion ...
Mengge Li, Huimin Li, Dejun Liu, Shunan Liu, Hui Yuan, Yan Wu, Min Du, Yuan Fang, Jin Li, Hui Cong, Dan Zhao, Chunsun Fan, Qing Wang, Cenkai Shen, Yu Gan, Yongwei Sun, Hong Tu   +16 more
wiley   +1 more source

Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins

Nature Communications
Nucleotidyltransferases (NTases) control diverse physiological processes, including RNA modification, DNA replication and repair, and antibiotic resistance.
Tom J. Arrowsmith, Xibing Xu, Shangze Xu, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K. Bronowska, Pierre Genevaux, Tim R. Blower   +8 more
doaj   +1 more source

Towards the control of biofilm formation in Anabaena (Nostoc) sp. PCC7120: novel insights into the genes involved and their regulation

New Phytologist, Volume 247, Issue 4, Page 1805-1825, August 2025.
Summary Cyanobacteria are major components of biofilms in light‐exposed environments, contributing to nutrient cycling, nitrogen fixation and global biogeochemical processes. Although nitrogen‐fixing cyanobacteria have been successfully used in biofertilization, the regulatory mechanisms underlying biofilm formation remain poorly understood.
Irene Olivan‐Muro, Jorge Guío, Germán Alonso‐Tolo, Emma Sevilla, María F. Fillat   +4 more
wiley   +1 more source

Multi‐Omic Analysis of Glutamate Excitotoxicity in Primary Neuronal Cultures

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
Our study on rat neuron cells found 250 μM glutamate to be toxic, causing neuron death. We identified genes in pathways linked to apoptosis, neuron plasticity, and cell signaling, along with proteins regulating the cell cycle and tumor proliferation.
Jennifer H. Nguyen, Xiaolu Zhang, Hunter M. Eby, Khaled Alganem, William G. Ryan, Ali Sajid lmami, Anna E. Lundh, Anvitha R. Madhavaram, James D. Bretz, Ethel Tackie‐Yarboi, Kelsee Zajac, William S. Messer Jr., Isaac T. Schiefer, Robert E. McCullumsmith   +13 more
wiley   +1 more source

cGAS/STING‐Independent Induction of Type I Interferon by Inhibitors of the Histone Methylase KDM5B

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Mechanism of HEXIM1 regulation of Type I Interferon. ABSTRACT Studies support the role of hexamethylene bis‐acetamide [HMBA] induced protein 1 (HEXIM1) as a tumor suppressor. We previously reported that the histone demethylase, KDM5B, inhibits the expression of HEXIM1, and KDM5B inhibitors (KDM5Bi) upregulate HEXIM1 expression. As a consequence, KDM5Bi
Monica M. Montano, I‐Ju Yeh, Wannarasmi Ketchart   +2 more
wiley   +1 more source

Kinetic analysis of rabbit liver tRNA nucleotidyltransferase.

Journal of Biological Chemistry, 1978
The kinetic properties of rabbit liver tRNA nucleotidyltransferase were examined. Our results indicate that incorporation of AMP into tRNA-C-C at pH 9.4 proceeds by a rapid equilibrium Random Bi Bi mechanism. This conclusion was supported by bisubstrate initial velocity studies, dead end and product inhibition, and isotope exchange at equilibrium and ...
M.P. Deutscher, J.A. Evans
openaire   +3 more sources

Effects of nucleotide substitutions within the T-loop of precursor tRNAs on interaction with ATP/CTP:tRNA nucleotidyltransferases from Escherichia coli and yeast.

Biochemical Journal, 1996
Recognition of tRNA and tRNA-like substrates by the enzyme ATP/CTP:tRNA nucleotidyltransferase requires chemically intact nucleotides within the T-loop, especially at positions 57 and 58, which are invariant purines among naturally occurring tRNAs.
Z. Li, K. A. Gillis, L. A. Hegg, J. Zhang, D. L. Thurlow   +4 more
semanticscholar   +1 more source